INTERVAL (investigation of NICE technologies for enabling risk-variable-adjusted-length) dental recalls trial: a multicentre randomised controlled trial investigating the best dental recall interval for optimum, cost-effective maintenance of oral health in dentate adults attending dental primary care

Background Traditionally, patients at low risk and high risk of developing dental disease have been encouraged to attend dental recall appointments at regular intervals of six months between appointments. The lack of evidence for the effect that different recall intervals between dental check-ups have on patient outcomes, provider workload and healthcare costs is causing considerable uncertainty for the profession and patients, despite the publication of the NICE Guideline on dental recall. The need for primary research has been highlighted in the Health Technology Assessment Group’s systematic review of routine dental check-ups, which found little evidence to support or refute the practice of encouraging 6-monthly dental check-ups in adults. The more recent Cochrane review on recall interval concluded there was insufficient evidence to draw any conclusions regarding the potential beneficial or harmful effects of altering the recall interval between dental check-ups. There is therefore an urgent need to assess the relative effectiveness and cost-benefit of different dental recall intervals in a robust, sufficiently powered randomised control trial (RCT) in primary dental care. Methods This is a four year multi-centre, parallel-group, randomised controlled trial with blinded outcome assessment based in dental primary care in the UK. Practitioners will recruit 2372 dentate adult patients. Patient participants will be randomised to one of three groups: fixed-period six month recall, risk-based recall, or fixed-period twenty-four month recall. Outcome data will be assessed through clinical examination, patient questionnaires and NHS databases. The primary outcomes measure gingival inflammation/bleeding on probing and oral health-related quality of life. Discussion INTERVAL will provide evidence for the most clinically-effective and cost-beneficial recall interval for maintaining optimum oral health in dentate adults attending general dental practice

WISDOM Project - X. The morphology of the molecular ISM in galaxy centres and its dependence on galaxy structure

We use high-resolution maps of the molecular interstellar medium (ISM) in the centres of eighty-six nearby galaxies from the millimetre-Wave Interferometric Survey of Dark Object Masses (WISDOM) and Physics at High Angular Resolution in Nearby GalaxieS (PHANGS) surveys to investigate the physical mechanisms setting the morphology of the ISM at molecular cloud scales. We show that early-type galaxies tend to have smooth, regular molecular gas morphologies, while the ISM in spiral galaxy bulges is much more asymmetric and clumpy when observed at the same spatial scales. We quantify these differences using non-parametric morphology measures (Asymmetry, Smoothness and Gini), and compare these measurements with those extracted from idealised galaxy simulations. We show that the morphology of the molecular ISM changes systematically as a function of various large scale galaxy parameters, including galaxy morphological type, stellar mass, stellar velocity dispersion, effective stellar mass surface density, molecular gas surface density, star formation efficiency and the presence of a bar. We perform a statistical analysis to determine which of these correlated parameters best predicts the morphology of the ISM. We find the effective stellar mass surface (or volume) density to be the strongest predictor of the morphology of the molecular gas, while star formation and bars maybe be important secondary drivers. We find that gas self-gravity is not the dominant process shaping the morphology of the molecular gas in galaxy centres. Instead effects caused by the depth of the potential well such as shear, suppression of stellar spiral density waves and/or inflow affect the ability of the gas to fragment

What constitutes the best sex life for gay and bisexual men? Implications for HIV prevention.

BACKGROUND: While a large body of research has sought to understand HIV transmission risk behaviours among gay men, bisexual men and other men who have sex with men (MSM), less attention has been paid to the wider sexual health and well-being of this population. While some community-based organisations aim to support a more holistic sense of sexual well-being there is little evidence to draw on to inform their interventions. The current study sought to explore gay and bisexual men's conceptions of what constitutes the 'best sex'. METHOD: The EMIS survey of 2010 recruited more than 180,000 respondents from 38 European countries to complete an online questionnaire about sexual health and behaviour. The 12,942 English language, UK-based responses to the open ended question, "What's your idea of the best sex life?" were subjected to a detailed content analysis. A framework was devised to reflect and describe the key themes emerging from the data, which was then used to code all responses to one (or more) of these themes. Further statistical analysis sought to establish if and how responses differed according to key demographic variables. RESULTS: Eight themes emerged that capture the diversity of gay and bisexual men's sexual desires. Most common among responses was a desire for sex within committed relationships, followed by a desire for sex which is emotionally or psychologically connected. Men also expressed a desire for volume and variety in their sexual lives, and for sex that is free from physical, social or psychological harm. Comparative analysis identified that older men were less likely to idealise a relationship or emotional connection, but were more likely to specify the sexual acts or behaviours they wished to engage in. CONCLUSIONS: Attending to what men value or aspire to can help ensure interventions are engaging and meaningful to the target population. HIV prevention interventions need to attend to the broad range of sexual desires held by gay and bisexual men in delivery of holistic sexual health promotion that can help them to have the best sex with the least harm

WISDOM project - XI. Star formation efficiency in the bulge of the AGN-host Galaxy NGC 3169 with SITELLE and ALMA

The star formation efficiency (SFE) has been shown to vary across different environments, particularly within galactic starbursts and deep within the bulges of galaxies. Various quenching mechanisms may be responsible, ranging from galactic dynamics to feedback from active galactic nuclei (AGNs). Here, we use spatially resolved observations of warm ionized gas emission lines (Hβ, [O iii] λλ4959,5007, [N ii] λλ6548,6583, Hα and [S ii] λλ6716,6731) from the imaging Fourier transform spectrograph SITELLE at the Canada-France-Hawaii Telescope (CFHT) and cold molecular gas (12CO(2-1)) from the Atacama Large Millimeter/sub-millimeter Array (ALMA) to study the SFE in the bulge of the AGN-host galaxy NGC 3169. After distinguishing star-forming regions from AGN-ionized regions using emission-line ratio diagnostics, we measure spatially resolved molecular gas depletion times (τdep 1/SFE) with a spatial resolution of ≈100 pc within a galactocentric radius of 1.8 kpc. We identify a star-forming ring located at radii 1.25 ± 0.6 kpc with an average τdep of 0.3 Gyr. At radii <0.9 kpc, however, the molecular gas surface densities and depletion times increase with decreasing radius, the latter reaching approximately 2.3 Gyr at a radius ≈500 pc. Based on analyses of the gas kinematics and comparisons with simulations, we identify AGN feedback, bulge morphology and dynamics as the possible causes of the radial profile of SFE observed in the central region of NGC 3169