249 research outputs found
Adenylosuccinate lyase determination
Adenylosuccinate lyase determinatio
Arginosuccinate synthetase determination
Arginosuccinate synthetase determinatio
The Abruptex Mutations of Notch Disrupt the Establishment of Proneural Clusters in Drosophila
AbstractThe receptor encoded by the Notch gene plays a central role in preventing cells from making decisions about their fates until appropriate signals are present. This function of Notch requires the product of the Suppressor of Hairless gene. Loss of either Notch or Suppressor of Hairless function results in cells making premature and incorrect cell fate decisions, whilst increases in Notch signalling prevent cells from making these decisions. Here we find that the proneural clusters are not established correctly in certain Abruptex mutations of Notch and this failure to establish proneural clusters correctly is not due to increased Notch signalling during lateral inhibition. In addition we show that the overexpression of certain dominant negative Notch molecules can disrupt the initiation of proneural cluster development in a manner similar to the Abruptex mutants
The development of a robust, autonomous sensor network platform for environmental monitoring.
This paper describes an approach to the approaches being explored for a Sensor Network platform being developed for the DTI/NextWave technologies programme. The approach being adopted is to develop the system as a community of devices which use self-organising techniques to provide key functions. The devices are, largely, based on commodity technologies, thus providing a low cost basis. We give an outline of the approach and project and illustrate the techniques being developed with specific functions for: control, management, data retrieval and data quality control. The target application is off shore sea shelf monitoring; but the techniques being developed may be applied to a range of problems
Self-Organising Pattern Formation: Fruit Flies and Cell Phones
. The bristles of the fruit fly, Drosophila, form part of the peripheral nervous system of the animal. The pattern of these bristles in the adult is produced by self-organisation of cell types during embryonic and larval development. The mechanism of bristle differentiation has been the inspiration for the optimisation algorithm presented here. The algorithm is used to produce a dynamic channel plan for a cell phone network. Radio channels are a scarce resource and minimising interference is a significant problem for mobile network operators. 1. Introduction 1.1 Growing A Channel Allocation Plan The purpose of the work presented here is to show how the mechanisms of bristle differentiation in the fruit fly can be used as an inspiration for an online dynamic channel allocation algorithm. The self-organising nature of the fruit fly developmental process is preserved and with it the advantages of robustness and flexibility. The mechanisms used so effectively by nature to ensure that two..
A novel mechanism for routing in highly mobile Ad-hoc sencor networks
This paper describes a novel routing mechanism for a network of highly mobile sensor nodes that routes data over dynamically changing topologies, using only information from nearest neighbours. The preferred forwarding directions of mobile sensor nodes are modelled as vectors, and a scalar trigger is used to determine data forwarding. Simulations have demonstrated that this technique operates successfully in sparse networks, where node movements are unpredictable, and data generation by nodes is nonuniform. The application scenario is a self-configuring network of mobile nodes, floating in the sea, that is tracking the movements of a shoal of fish. The requirements of the technique in terms of memory are minimal, with very few parameters and very little code being needed, as is appropriate for the lowpowered microprocessors envisaged
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