1,470 research outputs found
Differentiation of ruminant transmissible spongiform encephalopathy isolate types, including bovine spongiform encephalopathy and CH1641 scrapie
With increased awareness of the diversity of transmissible spongiform encephalopathy (TSE) strains in the ruminant population, comes an appreciation of the need for improved methods of differential diagnosis. Exposure to bovine spongiform encephalopathy (BSE) has been associated with the human TSE, variant Creutzfeldt–Jakob disease, emphasizing the necessity in distinguishing low-risk TSE types from BSE. TSE type discrimination in ruminants such as cattle, sheep, goats and deer, requires the application of several prion protein (PrP)-specific antibodies in parallel immunochemical tests on brain homogenates or tissue sections from infected animals. This study uses in a single incubation step, three PrP-specific antibodies and fluorescent Alexa dye-labelled anti-mouse Fabs on a Western blot. The usual amount of brain tissue needed is 0.5 mg. This multiplex application of antibodies directed towards three different PrP epitopes enabled differential diagnosis of all established main features of classical scrapie, BSE and Nor98-like scrapie in sheep and goats, as well as the currently known BSE types C, H and L in cattle. Moreover, due to an antibody-dependent dual PrP-banding pattern, for the first time CH1641 scrapie of sheep can be reliably discriminated from the other TSE isolate types in sheep
The intercept of the BFKL pomeron from Forward Jets at HERA
Recently the H1 and ZEUS collaborations have presented cross sections for DIS
events with a forward jet. The BFKL formalism is able to produce an excellent
fit to these data. The extracted intercept of the hard pomeron suggests that
when all higher order corrections are taken into account the cross section will
still rise very rapidly as expected for low dynamics.Comment: 10 pages, one figure, accepted for publication in PL
EU accession and income growth:An empirical approach
The dynamic effects from EU membership are crucial for the new member states to catch up with the average income level in the old member states. To gauge the dynamic effects we follow a two-step procedure in which a gravity equation for bilateral trade shows the trade effect of EU membership and a growth regression yields the income effect of trade. Shared EU membership is found to increase trade between two of its member states with about 27%. EU membership may contribute to trade by inducing countries to improve the quality of their institutions. Trade increases by another 23% if institutions improve, yielding a total trade increase of 50%. Improved openness increases income by 38% according to our estimates. Adding a small direct effect of improved institutions on income, the total income effect of EU membership is 40% for the 12 new members and Turkey. This implies that EU membership, or its effect on trade and institutions, could lead to large economic gains for the new member states, but does not bring them economically on par with the old member states.</p
Dynamic Image-Based Modelling of Kidney Branching Morphogenesis
Kidney branching morphogenesis has been studied extensively, but the
mechanism that defines the branch points is still elusive. Here we obtained a
2D movie of kidney branching morphogenesis in culture to test different models
of branching morphogenesis with physiological growth dynamics. We carried out
image segmentation and calculated the displacement fields between the frames.
The models were subsequently solved on the 2D domain, that was extracted from
the movie. We find that Turing patterns are sensitive to the initial conditions
when solved on the epithelial shapes. A previously proposed diffusion-dependent
geometry effect allowed us to reproduce the growth fields reasonably well, both
for an inhibitor of branching that was produced in the epithelium, and for an
inducer of branching that was produced in the mesenchyme. The latter could be
represented by Glial-derived neurotrophic factor (GDNF), which is expressed in
the mesenchyme and induces outgrowth of ureteric branches. Considering that the
Turing model represents the interaction between the GDNF and its receptor RET
very well and that the model reproduces the relevant expression patterns in
developing wildtype and mutant kidneys, it is well possible that a combination
of the Turing mechanism and the geometry effect control branching
morphogenesis
Real space renormalization group approach to the 2d antiferromagnetic Heisenberg model
The low energy behaviour of the 2d antiferromagnetic Heisenberg model is
studied in the sector with total spins by means of a renormalization
group procedure, which generates a recursion formula for the interaction matrix
of 4 neighbouring " clusters" of size ,
from the corresponding quantities . Conservation
of total spin is implemented explicitly and plays an important role. It is
shown, how the ground state energies , approach each
other for increasing , i.e. system size. The most relevant couplings in the
interaction matrices are generated by the transitions
between the ground states
() on an -cluster of size , mediated
by the staggered spin operator Comment: 18 pages, 8 figures, RevTe
Fast coarsening in unstable epitaxy with desorption
Homoepitaxial growth is unstable towards the formation of pyramidal mounds
when interlayer transport is reduced due to activation barriers to hopping at
step edges. Simulations of a lattice model and a continuum equation show that a
small amount of desorption dramatically speeds up the coarsening of the mound
array, leading to coarsening exponents between 1/3 and 1/2. The underlying
mechanism is the faster growth of larger mounds due to their lower evaporation
rate.Comment: 4 pages, 4 PostScript figure
Tunneling spectra of submicron BiSrCaCuO intrinsic Josephson junctions: evolution from superconducting gap to pseudogap
Tunneling spectra of near optimally doped, submicron
BiSrCaCuO intrinsic Josephson junctions are presented,
and examined in the region where the superconducting gap evolves into
pseudogap. The spectra are analyzed using a self-energy model, proposed by
Norman {\it et al.}, in which both quasiparticle scattering rate and
pair decay rate are considered. The density of states derived
from the model has the familiar Dynes' form with a simple replacement of
by = ( + )/2. The
parameter obtained from fitting the experimental spectra shows a roughly linear
temperature dependence, which puts a strong constraint on the relation between
and . We discuss and compare the Fermi arc behavior
in the pseudogap phase from the tunneling and angle-resolved photoemission
spectroscopy experiments. Our results indicate an excellent agreement between
the two experiments, which is in favor of the precursor pairing view of the
pseudogap.Comment: 7 pages, 6 figure
Unconventional MBE Strategies from Computer Simulations for Optimized Growth Conditions
We investigate the influence of step edge diffusion (SED) and desorption on
Molecular Beam Epitaxy (MBE) using kinetic Monte-Carlo simulations of the
solid-on-solid (SOS) model. Based on these investigations we propose two
strategies to optimize MBE growth. The strategies are applicable in different
growth regimes: During layer-by-layer growth one can exploit the presence of
desorption in order to achieve smooth surfaces. By additional short high flux
pulses of particles one can increase the growth rate and assist layer-by-layer
growth. If, however, mounds are formed (non-layer-by-layer growth) the SED can
be used to control size and shape of the three-dimensional structures. By
controlled reduction of the flux with time we achieve a fast coarsening
together with smooth step edges.Comment: 19 pages, 7 figures, submitted to Phys. Rev.
Measurements of the Mass and Full-Width of the Meson
In a sample of 58 million events collected with the BES II detector,
the process J/ is observed in five different decay
channels: , , (with ), (with
) and . From a combined fit of all five
channels, we determine the mass and full-width of to be
MeV/ and
MeV/.Comment: 9 pages, 2 figures and 4 table. Submitted to Phys. Lett.
Search for the Rare Decays J/Psi --> Ds- e+ nu_e, J/Psi --> D- e+ nu_e, and J/Psi --> D0bar e+ e-
We report on a search for the decays J/Psi --> Ds- e+ nu_e + c.c., J/Psi -->
D- e+ nu_e + c.c., and J/Psi --> D0bar e+ e- + c.c. in a sample of 5.8 * 10^7
J/Psi events collected with the BESII detector at the BEPC. No excess of signal
above background is observed, and 90% confidence level upper limits on the
branching fractions are set: B(J/Psi --> Ds- e+ nu_e + c.c.)<4.8*10^-5, B(J/Psi
--> D- e+ nu_e + c.c.) D0bar e+ e- + c.c.)<1.1*10^-5Comment: 10 pages, 4 figure
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