31 research outputs found

    Regulation of proteasome assembly and activity in health and disease

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    COVID-19, national culture, and privacy calculus: factors predicting the cross-cultural acceptance and uptake of contact-tracing technologies

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    The use of information technologies for the public interest, such as COVID-19 tracking apps that aim to reduce the spread of COVID-19 during the pandemic, involve a dilemma between public interest benefits and privacy concerns. Critical in resolving this conflict of interest are citizens’ trust in the government and the risks posed by COVID-19. How much can the government be trusted to access private information? Furthermore, to what extend do the health benefits posed by the technology outweigh the personal risks to one's privacy? We hypothesize that citizens’ acceptance of the technology can be conceptualized as a calculus of privacy concerns, government trust, and the public benefit of adopting a potentially privacy-encroaching technology. The importance that citizens place on their privacy and the extent to which they trust their governments vary though out the world. The present study examined the public’s privacy calculus across nine countries (Australia, Germany, Italy, Japan, Spain, Switzerland, Taiwan, the United Kingdom, and the United States) focusing on social acceptance of contact-tracing technologies during the COVID-19 pandemic. We found that across countries, privacy concerns were negatively associated with citizens’ acceptance of the technology, while government trust, perceived effectiveness of the technology, and the health threats of COVID-19 were positively associated. National cultural orientations moderate the effects of the basic factors of privacy calculus. In particular, individualism (value of the individual) amplified the effect of privacy concerns, whereas general trust (trust in the wider public) amplified the effect of government trust. National culture therefore requires careful attention in resolving public policy dilemmas of privacy, trust, and public interest

    All motors have to decide is what to do with the DNA that is given them

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    Resting Discharge Patterns of Macular Primary Afferents in Otoconia-Deficient Mice

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    Vestibular primary afferents in the normal mammal are spontaneously active. The consensus hypothesis states that such discharge patterns are independent of stimulation and depend instead on excitation by vestibular hair cells due to background release of synaptic neurotransmitter. In the case of otoconial sensory receptors, it is difficult to test the independence of resting discharge from natural tonic stimulation by gravity. We examined this question by studying discharge patterns of single vestibular primary afferent neurons in the absence of gravity stimulation using two mutant strains of mice that lack otoconia (OTO−; head tilt, het-Nox3, and tilted, tlt-Otop1). Our findings demonstrated that macular primary afferent neurons exhibit robust resting discharge activity in OTO− mice. Spike interval coefficient of variation (CV = SD/mean spike interval) values reflected both regular and irregular discharge patterns in OTO− mice, and the range of values for rate-normalized CV was similar to mice and other mammals with intact otoconia although there were proportionately fewer irregular fibers. Mean discharge rates were slightly higher in otoconia-deficient strains even after accounting for proportionately fewer irregular fibers [OTO− = 75.4 ± 31.1(113) vs OTO+ = 68.1 ± 28.5(143) in sp/s]. These results confirm the hypothesis that resting activity in macular primary afferents occurs in the absence of ambient stimulation. The robust discharge rates are interesting in that they may reflect the presence of a functionally ‘up-regulated’ tonic excitatory process in the absence of natural sensory stimulation
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