KTC De Marke: twee decennia innovaties voor duurzame melkveehouderij

De Marke, Proefbedrijf voor Melkveehouderij en Milieu bestaat dit jaar 20 jaar. Met militaire precisie is destijds de strategie, opzet en ontwikkeling van dit melkveeproefbedrijf door Frans Aarts, Edo Biewinga en Richard Donker vastgelegd in De Marke-rapport nr. 1: 'Melkveehouderij bij stringente milieunormen'. Nu, 20 jaar later, is er mede door hun aanzet meer bereikt dan we voor mogelijk hielden. Koeien melken met minimale belasting van de omgeving: de melkveehouderij is en blijft een gewaardeerde voedselproducent die schoon werkt in een fraai landschap. Alle reden om hier in 2012 uitgebreid bij stil te staan

Epidermal growth factor receptor (EGFR) biology and human oral cancer

Dysregulation of the epidermal growth factor receptor (EGFR) is one of the most frequently studied molecular events leading to oral carcinogenesis. Overexpression of EGFR is a common event in many human solid tumors. Elevated levels of EGFR mRNA in human cancer occur with and without gene rearrangement. Structural alterations in the receptor can also result in the dysregulation of the EGFR pathway. EGFR overexpression without gene re-arrangement is frequently observed in human oral cancers. However, little is known whether structural alterations in the receptor or perturbations in the EGFR pathway contribute to oral carcinogenesis. Several preliminary studies suggest that EGFR-targeted therapeutic approaches might be successful in controlling oral cancer

Collected Poems of Emily Dickinson

255 ha

Cognitive control, cognitive search, and motivational salience: a systems neuroscience approach

An essential facet of adaptive and versatile behavior is the ability to prioritize actions in response to dynamically changing circumstances, in particular when circumstances require the coordination of a planned course of action vis-à-vis instantaneous urges and extraneously triggered reactions. This chapter focuses on one aspect of cognitive search: the exploration of internal and external milieu for motivationally salient events (stimuli that are novel, ambiguous, infrequent, deviant, or unexpected, or register as a risk for undesirable outcomes or a risk for the exhaustion of resources) which may require appropriate adaptive action. A neurocognitive framework is described for understanding how cognitive control and cognitive search are modulated by motivationally salient events. This framework emphasizes the integration of a salience network in the brain with other large-scale neural networks, neurotransmitter systems, and homeostatic (autonomic nervous system) functioning. The anterior insula cortex and anterior cingulate cortex are core nodes of a salience network that monitors for motivationally salient stimuli. This framework helps to amalgamate findings from disparate literatures into a common conjecture and highlights the role of motivational salience in modulating cognitive search and cognitive control. The salience network transforms salience signals into an orienting response which serves to recruit the necessary physiological arousal and to engage task-relevant networks (involving attentional, working-memory, and adaptive action selection processes) while disengaging task-negative networks. Using representative examples as instructive points in case, it is argued that this integrative systems-neuroscience framework provides a parsimonious account of salience processing, and may provide novel insights into the neural basis of individual differences among healthy as well as pathological populations

Novel topologically complex scaffold derived from alkaloid haemanthamine

The generation of natural product-like compound collections has become an important area of research due to low hit rates found with synthetic high-throughput libraries. One method of generating compounds occupying the areas of chemical space not accessible to synthetic planar heterocyclic structures is the utilization of natural products as starting materials. In the current work, using a ring-closing iodoalkoxylation reaction, alkaloid haemanthamine was transformed into a unique structural framework possessing an intricate ring system and a large number of stereocenters. The structure of the new compound was confirmed with an X-ray analysis. A small number of derivatives of this new compound were synthesized as a demonstration of the possibility of generating a large natural product-like compound collection based on the new structural framework.SCOPUS: ar.jinfo:eu-repo/semantics/publishe