FUTURE INNOVATION TRENDS IN LATIN AMERICA

This article off ers an analysis of innovation activities in three Latin American countries. Such components as the role of science, business communities, and public policies in the transition to a knowledge-based economy are analyzed. Based on the Gibbons Model, innovative models that are being implemented inBrazil,Chile, andMexicoare compared. The data obtained may be used as a practical tool in developing countries

A36 The TP53 mutations in the Russian patients with de novo DLBCL

BackgroundTP53 dysfunction is implicated in lymphomagenesis and disease progression. Information about the frequency and spectrum of TP53 mutations in the Russian pathients with diffuse large B-cell lymphoma (DLBCL) in the current version of the IARC TP53 Mutation Database R17 is not represented. The goal of this work was to study the frequency, spectrum and functional significance of TP53 mutations in Russian patients with DLBCL.Material and methodsAt the present time the pilot group of 14 patients were included in the study. Diagnosis was assessed according to the criteria of the WHO classification system. Genomic DNA was isolated from formalin-fixed, paraffin embedded tissue blocks. Direct sequence analysis of gene TP53 was performed according to the IARC protocol, 2010 update.ResultsIn two patients were identified single nucleotide substitutions that are not described in the current version of the PubMed database. All of mutations occurred in the DNA-binding domain of p53. The nonsense mutation Arg196Ter was detected in one patient. Previously it was shown that formation of this premature stop codon might activate the nonsense-mediated RNA decay pathway. The second patient had two missense mutations – Leu130Phe and Arg156Cys. The first of them leads to p53 inactivation according to the analysis of the functional importance of amino acid substitutions using service PolyPhen-2.ConclusionWe detected TP53 mutation in 14% cases. The mutational rate in our study is in good agreement with other studies where the frequency of the TP53 mutations in patients with DLBCL ranged mostly from 13% to 23%

ДИНАМИКА ИННОВАЦИЙ В ЛАТИНСКОЙ АМЕРИКИ

This article off ers an analysis of innovation activities in three Latin American countries. Such components as the role of science, business communities, and public policies in the transition to a knowledge-based economy are analyzed. Based on the Gibbons Model, innovative models that are being implemented inBrazil,Chile, andMexicoare compared. The data obtained may be used as a practical tool in developing countries.Данная статья посвящена анализу инновационной активности ряда стран Латинской Америки. Проанализированы такие составляющие, как роль науки, бизнес-сообществ, а также государственная политика, направленная на переход к экономике, основанной на научных знаниях. На основании «the Gibbon’s Model» проведено сравнение инновационных моделей, которые реализуются в Бразилии, Чили и Мексике. Полученные данные можно использовать как практический инструментарий формирования инновационной политики в развивающихся странах. В заключение представлена оценка инновационной активности стран Латинской Америки

КОНЦЕПТУАЛЬНЫЕ ОСНОВЫ НЕОБХОДИМОСТИ ФОРМИРОВАНИЯ ТРОЙНОЙ СПИРАЛИ КАК ИННОВАЦИОННОЙ ВЕРШИНЫ ЭФФЕКТИВНОЙ НАЦИОНАЛЬНОЙ ЭКОНОМИКИ

The establishment of cooperation between the science, the state and business communities fosters the development and implementation of joint projects in various economic activity areas. The Triple Helix theory comprises the main participants forming research and technology clusters. In its turn, the development of clusters leads to the increase in economic activity of various regions of the countries where the Triple Helix is applied. Thus, the Triple Helix theory includes a whole system of players from various activity areas, with a relationship network established between them contributing to the formation of the efficient national economy. Формирование творческого сотрудничества между наукой, государством и бизнесом способствует развитию и функционированию совместных проектов в различных социально-экономических сферах. Теория «Тройной спирали» вбирает в себя научное обоснование участия всех главных сторон в формировании и функционировании научно-технологических кластеров. В свою очередь, создание кластеров ведет к увеличению экономической активности различных регионов страны, где реализуются научные принципы «Тройной спирали», так как теория «Тройной спирали» – это приведение в эффективную систему роли всех участников реализации различных инвестиционных проектов с приведением их взаимоотношений в экономически рациональное русло, обусловливающее формирование эффективной национальной экономики государства.

Gradients of Taxonomic Diversity among Local Floras in the Russian Arctic

Latitudinal and longitudinal changes in taxonomic variables were analyzed in 319 local floras in the Russian Arctic. Within the studied segment of latitudinal gradient, most changes can be described in terms of linear regression with negative coefficients (a number of species, genera and families), or positive coefficients (a proportion of the leading families and genera). However, the mean number of species in a family or genus almost does not change with increasing latitude, although it slightly increases as one moves eastward. The proportion of monocots does not correlate with latitude, but slightly decreases as one moves eastward. Proportions of various families change asynchronously. Although correlation with longitude was less pronounced, mean species richness was specific to many subprovinces, even within a certain subzone. These differences reflect both the diversity of landscapes and the history of flora formation. Keywords: the Arctic, local floras, latitudinal and longitudinal gradient, floristic subprovince

Physical development of preterm monochorionic diamniotic twins at birth: retrospective cohort study

Background. Much controversy surrounds the estimation of anthropometric parameters in multiple newborns. In newborn monochorionic diamniotic twins, these parameters can be affected by specific antenatal complications.Objectives. To estimate the physical development parameters of preterm monochorionic diamniotic twins according to standards proposed within the INTERGROWTH-21st project, taking specific intrauterine complications into account.Methods. The anthropometric data were analyzed in 148 pairs of newborn monochorionic diamniotic twins, who were divided into three groups according to the presence of specific intrauterine complications: Group I (n = 56 pairs) — twin-to-twin transfusion syndrome (TTTS); Group II (n = 38 pairs) — selective intrauterine growth restriction (sIUGR); Group III (n = 58 pairs) — absence of the above-mentioned specific complications. The obtained data were statistically processed on a personal computer via variation statistics methods using Microsoft Excel spreadsheets (Microsoft, USA) and an online service available at https://medstatistic.ru.Results. Newborns with sIUGR (37–100.0%) and 26 (49.1%) donors fell into the category of newborns light for gestational age. Disharmonious (3–10th percentile) and markedly disharmonious (below the 3rd percentile) physical development at birth was most commonly observed in newborns with sIUGR and, to a lesser extent, in donors (OR — 9.2; 95% CI — 3.2–24.3; p < 0.05), which was noted only occasionally in monochorionic twins from other groups. A combined decrease in the values of birth centiles for head circumference, body weight, and body length was found in 13 (35.1%) newborns with sIUGR and in 12 (22.6%) donors, which may mark the severity of antenatal complications and the development of neurological deficit.Conclusion. Monochorionic diamniotic twins include newborns having greater and lower body weights. In the newborn having a lower birth weight, specific complications associated with monochorionic multiple pregnancy result in body weight and length deficit, disharmonious development due to the lack of nourishment (22.6% in the TTTS group and 73.0% in the sIUGR group), as well as delayed head circumference growth in 56.8% of newborns with sIUGR

Трансформация инновационных процессов и социокультурной специфики Южной Кореи в рамках четвертой индустриальной революции

Purpose: the main purpose of this article is to explore the specific characteristics of the innovation development of South Korea. To achieve this goal the following tasks must be solved in the article: research the main principles and steps in the development of South Korea; identify and analyze the successful factors of the South Korean «economic miracle» that will continue contributing to the development and growth of the country; describe the cultural and organizational factors limiting the speed of transformation of South Korea under the fourth industrial revolution.Methods: the main methods of the research are system, structural and qualitative analyses. For the study, statistical data and articles in Russian and foreign scientific and analytical publications were used. The article is contributed with the empirical findings from the case study conducted during direct involvement of the authors in one of the industrial companies of South Korea.Results: an in-depth analyses of the transformation periods during the innovation development of South Korea was carried out, which made it possible to formulate the conclusion about existing barriers originated in the organisational approaches used to achieve the former industrial success. The problems constraining the new paradigm shift are analyzed.Conclusions and Relevance: the materials stated in the article show that in modern conditions, transition of South Korea towards Industry 4.0 is constrained by several unique factors, that used to be the key success elements in the former stages of the innovation development of the country. The research conducted in this article represents the value to the activities of various organizations interested in the innovation development, especially for development of innovation policies from the aspect of the importance of oranisational and cultural behavior at a national level. Practical application of the suggested conclusions allows hierarchical and monocultural organisations to transition to the Industry 4.0 with the consideration of important economic and social dynamics. Цель: Основная цель статьи состоит в исследовании особенностей инновационного развития Южной Кореи. Для достижения поставленной цели авторами были исследованы основные принципы и этапы инновационного развития государства, выявлены и проанализированы сильные стороны, способствовавшие «экономическому чуду» Южной Кореи, а также поднят вопрос культурных и организационных барьеров, сдерживающих темп трансформации экономики в рамках четвертой индустриальной революции.Методология проведения работы: В представленной статье использована совокупность методов системного, структурного и качественного анализа. Представленное исследование проведено на основе изучения и обобщения теоретического материала и практического опыта, накопленного в ходе многолетней работы одного из авторов исследования в корейской корпорации. Для проведения исследования использовались статистические данные, статьи в российских и иностранных изданиях, а также результаты эмпирического анализа.Результаты работы: Проведен анализ характерных особенностей динамики инновационного развития Южной Кореи, что позволило сформулировать тезис о существующих пережитках, тормозящих прогресс в рамках новой парадигмы. Проанализированы проблемы, сдерживающие трансформацию промышленной экономики Южной Кореи.Выводы: Материалы, приведенные в статье, показывают, что в современных условиях переход Южной Кореи к четвертой индустриальной революции осложнен спецификой факторов, обусловивших успех инновационного прогресса в предыдущие периоды. Результаты исследования, изложенные в статье, важны для изучения шагов, необходимых для трансформации бизнес-процессов и корпоративной культуры в целях дальнейшего инновационного развития, а также учета социокультурной специфики страны при разработке инновационной политики. Изученный опыт возможно использовать при формировании экономики, основанной на знаниях, и в России. Практическое применение метода открытых инноваций позволяет совершенствовать переход в эпоху четвертой индустриальной революции применительно к иерархичным монокультурным структурам с учетом актуальных экономических и социальных тенденций.

ПРОЦЕСС ФОРМИРОВАНИЯ ПРЕДПРИНИМАТЕЛЬСКИХ УНИВЕРСИТЕТОВ В РОССИИ

The article to focus on external and internal factors that impacted the ability of universities to transfer technologies from the public to the private market inRussia. External university factors include national and regional commercialization policy and environment. Internal university factors focus on policy, culture, and organization of technology transfer within the university.В статье проведен анализ опыта передачи технологий (инноваций) в предпринимательских университетах России. Основными критериями анализа являются внешние и внутренние факторы, которые повлияли на способность университетов в вопросе передачи технологий из государственного сектора в частный рынок. Внешние факторы включают региональную и национальную политику коммерциализации. Внутренние факторы включают культурный аспект в организациях передачи технологий в рамках университетов

Influence of sanatorium treatment with thermotherapy on the adaptive capacity of hard-working people

370 apparently healthy men aged 27 to 35 with considerable mental and physical burden were examined at the sanatorium. They were divided into two groups depending on the duration of rehabilitation. Group 1 consisted of 226 men with rehabilitation period from 18 to 21 days. Group 2 comprised 144 men with rehabilitation period from 10 to 14 days. Each group was subdivided into three subgroups: A, B and C. Patients of Group 1 subgroup A visited cryochamber, patients of Group 1 subgroup B visited infrared sauna, and patients of Group 1 subgroup C visited vibration sauna every second day. Patients of Group 2 subgroups A, B and C had the same procedures every day. Dynamic indicators of nonspecific adaptive response, hemodynamics, vascular adrenergic reactivity of skin, blood coagulation system, lipid and carbohydrate metabolism of all patients were studied. The results allowed us to conclude that all therapeutic complexes could be used in the restoration of adaptive capacity of hard-working people. Cryotherapy performed every second day was the most effective

INFLUENCE OF TRANEXAMIC ACID ON HEMORRHAGE AT THE REVISION HIP REPLACEMENT SURGERY

The article describes the results of investigation of the influence of tranexamic acid, on hemostasis system, at the revision hip replacement surgery. Correlation of changes in hemostasis system, and hemorrhage in intra-and postoperative periods, frequency of hemotransfusion, at the stages of the operation and in postoperative period, were evaluated. Use of tranexamic acid, at the revision hip replacement surgeries reduces perioperative hemorrhage