The importance of user in ISD. Do we really teach?

In 1999, the European Higher Education Area (EHEA) defined the framework that regulates all degrees,including Computer Engineering (CE), within the environment of the European Union. Each country, in turn, regulated each of these studies on the basis of that common framework. In the case of Computer Engineering there are concrete competences that refer to the effective incorporation of user and need for Information Technology (IT) professionals to learn how to manage and work in multidisciplinary environments. However, these competencies are difficult to teach to students. This paper presents a critical view of the way we are teaching future developers of information systems to work with user. Besides, it analyses the consequences that it may bring to future professionals. For this purpose, an experiment at three different universities in Europe has been carried out. This paper also offers some considerations and intends to motivate a future discussion on this topic.Ministerio de Economía y Competitividad TIN2016-76956-C3-2-R (POLOLAS)Ministerio de Economía y Competitividad TIN2015-71938-RED

Dietary protein defines stress resistance, oxidative damages and antioxidant defense system in Drosophila melanogaster

Dietary interventions have been previously shown to influence lifespan in diverse model organisms. Manipulations with macronutrients content including protein and amino acids have a significant impact on various fitness and behavioral traits in the fruit fly Drosophila melanogaster. Therefore, we asked if yeast amount of the diet could influence stress resistance and antioxidant defense system in Drosophila. We examined the effects of four diets differing in the relative level of yeast, as a source of protein, on resistance to cold, heat, starvation and oxidative stress induced by menadione as well as activities of antioxidant enzymes and levels of oxidative stress markers. Protein restriction as well protein-enriched diet led to a reduction of survival under starvation and oxidative stress conditions. However, enhanced resistance to heat shock was affected by high yeast concentration in the diet. Also, protein-rich diets resulted in higher activity of antioxidant enzymes. Increased levels of protein thiols, low-molecule mass thiols, lipid peroxides in response to high yeast concentration in the diet were detected in females only. Thus, we can assume that consumption of a high protein diet could induce oxidative stress in fruit fly

The Theoretical Description for Chlorantraniliprole Electrochemical Determination, Assisted by Squaraine Dye – Nano-CuS Composite

The theoretical description for the chlorantraniliprole electrochemical determination, assisted by the hybrid composite of squaraine dye with CuS nanoparticles has been described. The correspondent reaction mechanism has been proposed, and the correspondent mathematical model has been developed and analyzed by means of linear stability theory and bifurcation analysis. It has been shown that the chlorantraniprole electrochemical anodical determination on high potential may be efficiently provided by cupper sulfide nanoparticles, stabilized by the squaraine dye. On the other hand, the oscillatory and monotonic instability is also possible, being caused by DEL influences of the electrochemical stage. DOI: http://dx.doi.org/10.17807/orbital.v13i3.151

Theoretical Description for Omeprazole Cathodical Electrochemical Determination, Assisted by Omeprazole Electrochemical Determination, Assisted by the Composite Poly(1,2,4-triazole) – VO(OH)

Abstract: In this work, we describe theoretically the possibility of omeprazole electrochemical determination, assisted by the composite containing vanadium oxyhydroxide as an active substance and the polymer of 1,2,4-triazolic derivative as a mediator. The omeprazole molecule undergoes a sulfoxide to sulfide reduction process over a trivalent vanadium compound. The vanadium oxyhydroxide, at its turn, may be oxidized to a tetravalent state, represented in two forms. The electroanalytical process behavior will be illustrated by a trivariate equation-set, analysis of which confirms the efficiency of the composite of poly (1,2,4-triazole) with VO(OH). Vanadium (III) oxyhydroxide may be efficiently used for omeprazole detection both in pharmaceutical formulations, food, and biological liquids

A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction

Background: Carbohydrates play a major role in cell signaling in many biological processes. We have developed a set of glycomimetic drugs that mimic the structure of carbohydrates and represent a novel source of therapeutics for endothelial dysfunction, a key initiating factor in cardiovascular complications. Purpose: Our objective was to determine the protective effects of small molecule glycomimetics against free fatty acid­induced endothelial dysfunction, focusing on nitric oxide (NO) and oxidative stress pathways. Methods: Four glycomimetics were synthesized by the stepwise transformation of 2,5­dihydroxybenzoic acid to a range of 2,5­substituted benzoic acid derivatives, incorporating the key sulfate groups to mimic the interactions of heparan sulfate. Endothelial function was assessed using acetylcholine­induced, endotheliumdependent relaxation in mouse thoracic aortic rings using wire myography. Human umbilical vein endothelial cell (HUVEC) behavior was evaluated in the presence or absence of the free fatty acid, palmitate, with or without glycomimetics (1µM). DAF­2 and H2DCF­DA assays were used to determine nitric oxide (NO) and reactive oxygen species (ROS) production, respectively. Lipid peroxidation colorimetric and antioxidant enzyme activity assays were also carried out. RT­PCR and western blotting were utilized to measure Akt, eNOS, Nrf­2, NQO­1 and HO­1 expression. Results: Ex vivo endothelium­dependent relaxation was significantly improved by the glycomimetics under palmitate­induced oxidative stress. In vitro studies showed that the glycomimetics protected HUVECs against the palmitate­induced oxidative stress and enhanced NO production. We demonstrate that the protective effects of pre­incubation with glycomimetics occurred via upregulation of Akt/eNOS signaling, activation of the Nrf2/ARE pathway, and suppression of ROS­induced lipid peroxidation. Conclusion: We have developed a novel set of small molecule glycomimetics that protect against free fatty acidinduced endothelial dysfunction and thus, represent a new category of therapeutic drugs to target endothelial damage, the first line of defense against cardiovascular disease

Thermoelectric microgenerators. Current status and prospects of application

Analysis of current status and prospects of using thermoelectric microgenerators, including organic-fueled ones, is performed. Developments of thermoelectric microgenerators presented in this review demonstrate that their increasingly wide use forms a separate, very important line of thermoelectricity – micropower generation with growing potential of practical applications for charging batteries, mobile phones, digital cameras and photocameras, power supply to small radio stations, other portable devices, including medical. The ways of increasing the efficiency of such devices and relevant lines of their wide use in practice are determined

Manifesto in defense of human-centred education in the age of artificial intelligence

Book abstract: This open access book explores the synergy between AI and education, highlighting its potential impact on pedagogical practices. It navigates the evolving landscape of AI-powered educational technologies and suggests practical ways to personalise instruction, nurture human-AI co-creativity, and transform the learning experience. Spanning from primary to higher education, this short and engaging volume proposes concrete examples of how educational stakeholders can be empowered in their AI literacy to foster creativity, inspire critical thinking, and promote problem-solving by embracing AI as a tool for expansive learning. Structured in three parts, the book starts developing the creative engagement perspective for learning and teaching to then present practical applications of AI in K-12 and higher education, covering different fields (teacher education, professional education, business education) as well as different types of AI supported tools (games, chatbots, and AI assisted assessment). It also delves into the ethical considerations, policy implications, and the central role educators play in harnessing the power of an AI informed educational experience