Introduction and Expression of a Rabbit β-globin Gene in Mouse Fibroblasts

The cloned chromosomal rabbit ß-globin gene has been introduced into mouse fibroblasts by DNA-mediated gene transfer (transformation). In this report, we examine the expression of the rabbit gene in six independent transformants that contain from 1 to 20 copies of the cloned globin gene. Rabbit globin transcripts were detected in two of these transformants at steady-state concentrations of 5 and 2 copies per cell. The globin transcripts from one cell line are polyadenylylated and migrate as 9S RNA on methylmercury gels. These transcripts reflect correct processing of the two intervening sequences but lack 48 ± 5 nucleotides present at the 5' terminus of rabbit erythrocyte globin mRNA

4d Conformal Field Theories and Strings on Orbifolds

We propose correspondences between 4d quantum field theories with N=2,1,0 (super)conformal invariance and Type IIB string theory on various orbifolds. We argue using the spacetime string theory, and check using the beta functions (exactly for N=2,1 and so far at 1-loop for the gauge couplings in the N=0 case), that these theories have conformal fixed lines. The latter case potentially gives well-defined non-supersymmetric vacua of string theory, with a mechanism for making the curvature and cosmological constant small at nontrivial string coupling. We suggest a correspondence between nonsupersymmetric conformal fixed lines and nonsupersymmetric string vacua with vanishing vacuum energy.Comment: 11 pages, harvmac big. Reference adde

Hodge Duality on the Brane

It has been claimed that whereas scalars can be bound to a Randall-Sundrum brane, higher p-form potentials cannot, in contradiction with the Hodge duality between 0-form and 3-form potentials in the five-dimensional bulk. Here we show that a 3-form in the bulk correctly yields a 2-form on the brane, in complete agreement with both bulk and brane duality. We also emphasize that the phenomenon of photon screening in the Randall-Sundrum geometry is ruled out by the bulk Einstein equation.Comment: 6 pages, Latex. We emphasize that the phenomenon of photon screening in the Randall-Sundrum geometry is ruled out by the bulk Einstein equatio

Experimental Verification of the Theory of Oscillating Airfoils

Measurements have been made of the lift on an airfoil in pitching oscillation with a continuous-recording, instantaneous-force balance. The experimental values for the phase difference between the angle of attack and the lift are shown to be in close agreement with theory

Dietary Patterns and Cognitive Function among Older Community-Dwelling Adults.

Diet may be an important modifiable risk factor for maintenance of cognitive health in later life. This study aimed at examining associations between common dietary indices and dietary patterns defined by factor analysis and cognitive function in older community-dwelling adults. Dietary information for 1499 participants from the Rancho Bernardo Study was collected in 1988⁻1992 and used to calculate the alternate Mediterranean diet score, Alternate Healthy Eating Index (AHEI)-2010 score and factor scores derived from factor analysis of nutrients. Global cognitive function, executive function, verbal fluency and episodic memory were assessed at approximate four-year intervals from 1988⁻2016. Linear mixed models were used to examine associations between dietary patterns and cognitive trajectories. Estimates for the highest vs. lowest tertile in models adjusting for age, sex, education, energy intake, lifestyle variables and retest effect showed greater adherence to the Mediterranean score was associated with better baseline global cognitive function (β (95% CI) = 0.33 (0.11, 0.55)). The AHEI-2010 score was not significantly associated with cognitive performance. Higher loading on a plant polyunsaturated fatty acid (PUFA)/vitamin E factor was associated with better baseline global cognitive function and executive function (β = 0.22 (0.02, 0.42) and β = -7.85 (-13.20, -2.47)). A sugar/low protein factor was associated with poorer baseline cognitive function across multiple domains. Dietary patterns were not associated with cognitive decline over time. Adherence to a healthy diet with foods high in PUFA and vitamin E and a low sugar to protein ratio, as typified by a Mediterranean diet, may be beneficial for cognitive health in late life

AdS Bubbles, Entropy and Closed String Tachyons

We study the conjectured connection between AdS bubbles (AdS solitons) and closed string tachyon condensations. We confirm that the entanglement entropy, which measures the degree of freedom, decreases under the tachyon condensation. The entropies in supergravity and free Yang-Mills agree with each other remarkably. Next we consider the tachyon condensation on the AdS twisted circle and argue that its endpoint is given by the twisted AdS bubble, defined by the double Wick rotation of rotating black 3-brane solutions. We calculated the Casimir energy and entropy and checked the agreements between the gauge and gravity results. Finally we show an infinite boost of a null linear dilaton theory with a tachyon wall (or bubble), leads to a solvable time-dependent background with a bulk tachyon condensation. This is the simplest example of spacetimes with null boundaries in string theory.Comment: 45 pages, 6 figures, harvmac, eq.(2.16) corrected, references adde

Local Eigenvalue Density for General MANOVA Matrices

We consider random n\times n matrices of the form (XX*+YY*)^{-1/2}YY*(XX*+YY*)^{-1/2}, where X and Y have independent entries with zero mean and variance one. These matrices are the natural generalization of the Gaussian case, which are known as MANOVA matrices and which have joint eigenvalue density given by the third classical ensemble, the Jacobi ensemble. We show that, away from the spectral edge, the eigenvalue density converges to the limiting density of the Jacobi ensemble even on the shortest possible scales of order 1/n (up to \log n factors). This result is the analogue of the local Wigner semicircle law and the local Marchenko-Pastur law for general MANOVA matrices.Comment: Several small changes made to the tex

On the Matrix Description of Calabi-Yau Compactifications

We point out that the matrix description of M-theory compactified on Calabi-Yau threefolds is in many respects simpler than the matrix description of a $T^6$ compactification. This is largely because of the differences between D6 branes wrapped on Calabi-Yau threefolds and D6 branes wrapped on six-tori. In particular, if we define the matrix theory following the prescription of Sen and Seiberg, we find that the remaining degrees of freedom are decoupled from gravity.Comment: 12 pages, harvmac big; comment on 4d N=1 theories change

A New Handle on de Sitter Compactifications

We construct a large new class of de Sitter (and anti de Sitter) vacua of critical string theory from flux compactifications on products of Riemann surfaces. In the construction, the leading effects stabilizing the moduli are perturbative. We show that these effects self-consistently dominate over standard estimates for further $\alpha^\prime$ and quantum corrections, via tuning available from large flux and brane quantum numbers.Comment: 26 pages, harvmac big. v2: Correction generalizing specific ingredients required for tunable negative term; conclusions and structure of potential unchange