Design and Fabrication of Three-Dimensional Scaffolds for Tissue Engineering of Human Heart Valves

We developed a new fabrication technique for 3-dimensional scaffolds for tissue engineering of human heart valve tissue. A human aortic homograft was scanned with an X-ray computer tomograph. The data derived from the X-ray computed tomogram were processed by a computer-aided design program to reconstruct a human heart valve 3-dimensionally. Based on this stereolithographic model, a silicone valve model resembling a human aortic valve was generated. By taking advantage of the thermoplastic properties of polyglycolic acid as scaffold material, we molded a 3-dimensional scaffold for tissue engineering of human heart valves. The valve scaffold showed a deviation of only +/- 3-4% in height, length and inner diameter compared with the homograft. The newly developed technique allows fabricating custom-made, patient-specific polymeric cardiovascular scaffolds for tissue engineering without requiring any suture materials. Copyright (c) 2008 S. Karger AG, Base

Proton-induced magnetic order in carbon: SQUID measurements

In this work we have studied systematically the changes in the magnetic behavior of highly oriented pyrolytic graphite (HOPG) samples after proton irradiation in the MeV energy range. Superconducting quantum interferometer device (SQUID) results obtained from samples with thousands of localized spots of micrometer size as well on samples irradiated with a broad beam confirm previously reported results. Both, the para- and ferromagnetic contributions depend strongly on the irradiation details. The results indicate that the magnetic moment at saturation of spots of micrometer size is of the order of $10^{-10}$ emu.Comment: Invited contribution at ICACS2006 to be published in Nucl. Instr. and Meth. B. 8 pages and 6 figure

3D-Hydrogen Analysis of Ferromagnetic Microstructures in Proton Irradiated Graphite

Recently, magnetic order in highly oriented pyrolytic graphite (HOPG) induced by proton broad- and microbeam irradiation was discovered. Theoretical models propose that hydrogen could play a major role in the magnetism mechanism. We analysed the hydrogen distribution of pristine as well as irradiated HOPG samples, which were implanted to micrometer-sized spots as well as extended areas with various doses of 2.25 MeV protons at the Leipzig microprobe LIPSION. For this we used the sensitive 3D hydrogen microscopy system at the Munich microprobe SNAKE. The background hydrogen level in pristine HOPG is determined to be less than 0.3 at-ppm. About 4.8e15 H-atoms/cm^2 are observed in the near-surface region (4 um depth resolution). The depth profiles of the implants show hydrogen located within a confined peak at the end of range, in agreement with SRIM Monte Carlo simulations, and no evidence of diffusion broadening along the c-axis. At sample with microspots, up to 40 at-% of the implanted hydrogen is not detected, providing support for lateral hydrogen diffusion.Comment: accepted for publication in Nucl. Instr. and Met

Robust Chauvenet Outlier Rejection

Sigma clipping is commonly used in astronomy for outlier rejection, but the number of standard deviations beyond which one should clip data from a sample ultimately depends on the size of the sample. Chauvenet rejection is one of the oldest, and simplest, ways to account for this, but, like sigma clipping, depends on the sample's mean and standard deviation, neither of which are robust quantities: Both are easily contaminated by the very outliers they are being used to reject. Many, more robust measures of central tendency, and of sample deviation, exist, but each has a tradeoff with precision. Here, we demonstrate that outlier rejection can be both very robust and very precise if decreasingly robust but increasingly precise techniques are applied in sequence. To this end, we present a variation on Chauvenet rejection that we call "robust" Chauvenet rejection (RCR), which uses three decreasingly robust/increasingly precise measures of central tendency, and four decreasingly robust/increasingly precise measures of sample deviation. We show this sequential approach to be very effective for a wide variety of contaminant types, even when a significant -- even dominant -- fraction of the sample is contaminated, and especially when the contaminants are strong. Furthermore, we have developed a bulk-rejection variant, to significantly decrease computing times, and RCR can be applied both to weighted data, and when fitting parameterized models to data. We present aperture photometry in a contaminated, crowded field as an example. RCR may be used by anyone at https://skynet.unc.edu/rcr, and source code is available there as well.Comment: 62 pages, 48 figures, 7 tables, accepted for publication in ApJ

Gamma-Ray Bursts as a Probe of the Very High Redshift Universe

We show that, if many GRBs are indeed produced by the collapse of massive stars, GRBs and their afterglows provide a powerful probe of the very high redshift (z > 5) universe.Comment: To appear in Proc. of the 5th Huntsville Gamma-Ray Burst Symposium, 5 pages, LaTe

Supernova 2012ec: Identification of the progenitor and early monitoring with PESSTO

We present the identification of the progenitor of the Type IIP SN 2012ec in archival pre-explosion HST WFPC2 and ACS/WFC F814W images. The properties of the progenitor are further constrained by non-detections in pre-explosion WFPC2 F450W and F606W images. We report a series of early photometric and spectroscopic observations of SN 2012ec. The r'-band light curve shows a plateau with M(r')=-17.0. The early spectrum is similar to the Type IIP SN 1999em, with the expansion velocity measured at Halpha absorption minimum of -11,700 km/s (at 1 day post-discovery). The photometric and spectroscopic evolution of SN 2012ec shows it to be a Type IIP SN, discovered only a few days post-explosion (<6d). We derive a luminosity for the progenitor, in comparison with MARCS model SEDs, of log L/Lsun = 5.15+/-0.19, from which we infer an initial mass range of 14-22Msun. This is the first SN with an identified progenitor to be followed by the Public ESO Spectroscopic Survey of Transient Objects (PESSTO).Comment: 6 pages, 3 figures, MNRAS accepte