387 research outputs found

    Capitalizing On Diversity: Interpersonal Congruence In Small Work Groups

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    We examine interpersonal congruence, the degree to which group members see others in the group as others see themselves, as a moderator of the relationship between diversity and group effectiveness. A longitudinal study of 83 work groups revealed that diversity tended to improve creative task performance in groups with high interpersonal congruence, whereas diversity undermined the performance of groups with low interpersonal congruence. This interaction effect also emerged on measures of social integration, group identification, and relationship conflict. By eliciting self-verifying appraisals, members of some groups achieved enough interpersonal congruence during their first ten minutes of interaction to benefit their group outcomes four months later. In contrast to theories of social categorization, the interpersonal congruence approach suggests that group members can achieve harmonious and effective work processes by expressing rather than suppressing the characteristics that make them unique.Managemen

    Personal Web Use in the Workplace: Why Does it Persist in a Context of Strict Security and Monitoring?

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    Over the last decade, Personal Web Use (PWU) in the workplace has received considerable attention. This study examined factors that both inhibit and encourage PWU behaviors. The context was a municipal government agency in the U.S. with strong policy and electronic restrictions on PWU. Our study builds on extant research byinvestigating both self-reported PWU (from an online survey of 116 users atthe agency) and objective reports fromthe agency’s electronic monitoring (EM) of PWU. Results of our hypothesis tests indicated that group norms,individual moral norms, and perceived time availability had an effect on PWU while boredom had no effect. Group norms moderated individual moral norms’ effect on PWU. Discrepancies between individuals’ self-reports and the agency’s electronic reports of PWU are explained in terms of differing perceptions of what defines PWU. We describe implications important to both scholars and practitioners

    Slope Failure in Loess. A detailed investigation Allandale, Banks Peninsula

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    This study investigates a slope failure complex in loess at Allandale, Lyttelton Harbour. Literature relevant to the slope stability and strength of Banks Peninsula loessial soils is reviewed. Laboratory and in situ strength testing shows that both C and P layer loess in a partially saturated state displays a significant reduction in undrained shear strength with increasing degree of saturation. Strength reduction can be attributed to reduced pore water tension due to capillary suction which results from an increased degree of saturation. The moisture controlled strength component in partially saturated loess can be defined by any two of dry density, moisture content and degree of saturation. When comparing loess C and P layer remoulded strengths with peak strengths, the P layer is significantly more sensitive to remoulding than C layer. Drained direct shear testing of C layer loess produces remoulded and peak strength parameters of c'=O, Ø'=28.4° and c'=6kPa, Ø '=28.4° respectively. Drained direct shear testing of P layer loess produced remoulded and peak shear strength parameters of c'=O, Ø '=28.4° and c'=20kPa, Ø '=28.4° respectively. The slope failure complex investigated has been formed by an earthflow initiated by a tension crack in C layer loess (which acts as an unconfined leaky aquifer). Subsequent retrogressive upslope and lateral migration of the slope failure complex involves "turfmat slides" in S layer loess which also acts as an unconfined leaky aquifer, and more tension crack initiated earth flows in C layer loess. Back analysis suggests both forms of slope movement may have failed by translational sliding at the base of their respective loess layer, with a piezometric level coincident with the ground surface. Mobilisation of the "turfmat slide", requires drained remoulded shear strengths, whereas mobilisation of the earth flow is more likely to involve drained peak shear strengths

    Intervention with Microfinance for AIDS and Gender Equity (IMAGE): Women's Engagement with the Scaled-up IMAGE Programme and Experience of Intimate Partner Violence in Rural South Africa.

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    The Intervention with Microfinance for AIDS and Gender Equity (IMAGE) programme has been scaled up to three provinces in South Africa. This paper explores associations between women's engagement in the intervention, intimate partner violence (IPV) and factors associated with IPV and partner abuse. We enrolled women receiving group-based microfinance loans plus gender training into the scaled-up IMAGE cohort study (n = 860). We present cross-sectional analysis on participants' characteristics and intervention engagement and use multivariate logistic regression to explore associations. 17% of women reported lifetime (95% CI 15 to 20%) and 7% past year (95% CI 5 to 9%) IPV, 9% past-year economic (95% CI 7 to 11%) and 11% past-year emotional (95% CI 9 to 14%) abuse. Women under 35 years had higher levels of IPV and emotional abuse. 53% of women attended all the trainings, 83% continuously borrowed and 98% agreed the training had a major impact on their life. Attendance was associated with improved partner relationships (χ2p < 0.001), but not lower IPV risk. Odds of past-year IPV decreased the more types of support (e.g. advice) women received from group members (aOR 0.27, p < 0.001 among those reporting all support versus none or some). A similar pattern was seen for economic, but not emotional, abuse. The scaled-up IMAGE intervention is widely acceptable and may support improvements in partner relationships, but younger women need to be targeted. Group support appears to be a potentially important component of the intervention

    Molecular profiling of single circulating tumor cells with diagnostic intention

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    Several hundred clinical trials currently explore the role of circulating tumor cell (CTC) analysis for therapy decisions, but assays are lacking for comprehensive molecular characterization of CTCs with diagnostic precision. We therefore combined a workflow for enrichment and isolation of pure CTCs with a non-random whole genome amplification method for single cells and applied it to 510 single CTCs and 189 leukocytes of 66 CTC-positive breast cancer patients. We defined a genome integrity index (GII) to identify single cells suited for molecular characterization by different molecular assays, such as diagnostic profiling of point mutations, gene amplifications and whole genomes of single cells. The reliability of >90% for successful molecular analysis of high-quality clinical samples selected by the GII enabled assessing the molecular heterogeneity of single CTCs of metastatic breast cancer patients. We readily identified genomic disparity of potentially high relevance between primary tumors and CTCs. Microheterogeneity analysis among individual CTCs uncovered pre-existing cells resistant to ERBB2-targeted therapies suggesting ongoing microevolution at late-stage disease whose exploration may provide essential information for personalized treatment decisions and shed light into mechanisms of acquired drug resistance

    Molecular profiling of single circulating tumor cells with diagnostic intention

    Get PDF
    Several hundred clinical trials currently explore the role of circulating tumor cell (CTC) analysis for therapy decisions, but assays are lacking for comprehensive molecular characterization of CTCs with diagnostic precision. We therefore combined a workflow for enrichment and isolation of pure CTCs with a non-random whole genome amplification method for single cells and applied it to 510 single CTCs and 189 leukocytes of 66 CTC-positive breast cancer patients. We defined a genome integrity index (GII) to identify single cells suited for molecular characterization by different molecular assays, such as diagnostic profiling of point mutations, gene amplifications and whole genomes of single cells. The reliability of >90% for successful molecular analysis of high-quality clinical samples selected by the GII enabled assessing the molecular heterogeneity of single CTCs of metastatic breast cancer patients. We readily identified genomic disparity of potentially high relevance between primary tumors and CTCs. Microheterogeneity analysis among individual CTCs uncovered pre-existing cells resistant to ERBB2-targeted therapies suggesting ongoing microevolution at late-stage disease whose exploration may provide essential information for personalized treatment decisions and shed light into mechanisms of acquired drug resistance
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