Integrated waveguides and deterministically positioned nitrogen vacancy centers in diamond created by femtosecond laser writing

Diamond's nitrogen vacancy (NV) center is an optically active defect with long spin coherence times, showing great potential for both efficient nanoscale magnetometry and quantum information processing schemes. Recently, both the formation of buried 3D optical waveguides and high quality single NVs in diamond were demonstrated using the versatile femtosecond laser-writing technique. However, until now, combining these technologies has been an outstanding challenge. In this work, we fabricate laser written photonic waveguides in quantum grade diamond which are aligned to within micron resolution to single laser-written NVs, enabling an integrated platform providing deterministically positioned waveguide-coupled NVs. This fabrication technology opens the way towards on-chip optical routing of single photons between NVs and optically integrated spin-based sensing

HI Fluctuations at Large Redshifts: I--Visibility correlation

We investigate the possibility of probing the large scale structure in the universe at large redshifts by studying fluctuations in the redshifted 1420 MHz emission from the neutral hydrogen (HI) at early epochs. The neutral hydrogen content of the universe is known from absorption studies for z<4.5. The HI distribution is expected to be inhomogeneous in the gravitational instability picture and this inhomogeneity leads to anisotropy in the redshifted HI emission. The best hope of detecting this anisotropy is by using a large low-frequency interferometric instrument like the Giant Meter-Wave Radio Telescope (GMRT). We calculate the visibility correlation function <V_nu(u) V_nu'(u)> at two frequencies nu and nu' of the redshifted HI emission for an interferometric observation. In particular we give numerical results for the two GMRT channels centered around nu =325 and 610 MHz from density inhomogeneity and peculiar velocity of the HI distribution. The visibility correlation is ~10^-9 to 10^-10 Jy^2. We calculate the signal-to-noise for detecting the correlation signal in the presence of system noise and show that the GMRT might detect the signal for integration times ~ 100 hrs. We argue that the measurement of visibility correlation allows optimal use of the uncorrelated nature of the system noise across baselines and frequency channels.Comment: 17 pages, 2 figures, Submitted to JA

Foregrounds for redshifted 21 cm studies of reionization: GMRT 153 MHz observations

Foreground subtraction is the biggest challenge for future redshifted 21 cm observations to probe reionization. We use a short GMRT observation at 153 MHz to characterize the statistical properties of the background radiation across ~ one degree to sub-arcminutes angular scales, and across a frequency band of 5 MHz with 62.5 kHz resolution. The statistic we use is the visibility correlation function, or equivalently the angular power spectrum C_l. We present the results obtained from using relatively unsophisticated, conventional data calibration procedures. We find that even fairly simple minded calibration allows one to estimate the visibility correlation function at a given frequency V_2(U,0). From our observations we find that V_2(U,0) is consistent with foreground model predictions at all angular scales except the largest ones probed by our observations where the the model predictions are somewhat in excess. On the other hand the visibility correlation between different frequencies kappa(U, Delta nu), seems to be much more sensitive to calibration errors. We find a rapid decline in kappa(U, Delta nu), in contrast with the prediction of less than 1 % variation across 2.5 MHz. In this case however, it seems likely that a substantial part of the discrepancy may be due to limitations of data reduction procedures.Comment: 10 pages, 7 figures, 1 table, Accepted for Publication in MNRA

Latrepirdine: Molecular mechanisms underlying potential therapeutic roles in Alzheimer’s and other neurodegenerative diseases

Latrepirdine (DimebonTM) was originally marketed as a non-selective antihistamine in Russia. It was repurposed as an effective treatment for patients suffering from Alzheimer’s disease (AD) and Huntington’s disease (HD) following preliminary reports showing its neuroprotective functions and ability to enhance cognition in AD and HD models. However, latrepirdine failed to show efficacy in phase III trials in AD and HD patients following encouraging phase II trials. The failure of latrepirdine in the clinical trials has highlighted the importance of understanding the precise mechanism underlying its cognitive benefits in neurodegenerative diseases before clinical evaluation. Latrepirdine has shown to affect a number of cellular functions including multireceptor activity, mitochondrial function, calcium influx and intracellular catabolic pathways; however, it is unclear how these properties contribute to its clinical benefits. Here, we review the studies investigating latrepirdine in cellular and animal models to provide a complete evaluation of its mechanisms of action in the central nervous system. In addition, we review recent studies that demonstrate neuroprotective functions for latrepirdine-related class of molecules including the β-carbolines and aminopropyl carbazoles in AD, Parkinson’s disease and amyotrophic lateral sclerosis models. Assessment of their neuroprotective effects and underlying biological functions presents obvious value for developing structural analogues of latrepirdine for dementia treatment

Using HI to probe large scale structures at z ~ 3

The redshifted 1420 MHz emission from the HI in unresolved damped Lyman-\alpha clouds at high z will appear as a background radiation in low frequency radio observations. This holds the possibility of a new tool for studying the universe at high-z, using the mean brightness temperature to probe the HI content and its fluctuations to probe the power spectrum. Existing estimates of the HI density at z~3 imply a mean brightness temperature of 1 mK at 320 Mhz. The cross-correlation between the temperature fluctuations across different frequencies and sight lines is predicted to vary from 10^{-7} K^2 to 10^{-8} K^2 over intervals corresponding to spatial scales from 10 Mpc to 40 Mpc for some of the currently favoured cosmological models. Comparing this with the expected sensitivity of the GMRT, we find that this can be detected with \~10 hrs of integration, provided we can distinguish it from the galactic and extragalactic foregrounds which will swamp this signal. We discuss a strategy based on the very distinct spectral properties of the foregrounds as against the HI emission, possibly allowing the removal of the foregrounds from the observed maps.Comment: 16 pages, includes 6 figures, accepted in JAA (minor revisions, references added

Decaying Neutrinos and Large Scale Structure Formation

We study the growth of density perturbations in a universe with unstable dark matter particles. The mass (m_\nu) range 30 eV < m_\nu < 10 keV with lifetimes ($t_d$) in the range 10^7 sec < t_d < 10^16 sec are considered. We calculate the COBE normalized matter power spectrum for these models. We find that it is possible to construct models consistent with observations for masses $m_\nu > 50 eV by adjusting t_d so as to keep the quantity (m_\nu(keV))^2 t_d(yr) constant at a value around 100. For m_\nu < 1 keV the power spectrum has extra power at small scales which could result in an early epoch of galaxy formation. We do not find any value of t_d which gives a viable model in the mass range m_\nu < 50 eV. We also consider the implications of radiatively decaying neutrinos---models in which a small fraction B << 1 of neutrinos decay into photons-which could possibly ionize the intergalactic medium (IGM) at high redshift. We show that the parameter space of decaying particles which satisfies the IGM observations does not give viable models of structure formation.Comment: 42 pages, 9 Postscript figures, Accepted in ApJ Supplemen

HI Fluctuations at Large Redshifts: III - Simulating the Signal Expected at GMRT

We simulate the distribution of neutral hydrogen (HI) at the redshifts z=1.3 and 3.4 using a cosmological N-body simulation along with a prescription for assigning HI masses to the particles. The HI is distributed in clouds whose properties are consistent with those of the damped Lyman-\alpha absorption systems (DLAs) seen in quasar spectra. The clustering properties of these clouds are identical to those of the dark matter. We use this to simulate the redshifted HI emission expected at 610 MHz and 325 MHz, two of the observing bands a the GMRT. These are used to predict the correlations expected between the complex visibilities measured at different baselines and frequencies in radio-interferometric observations with the GMRT. The visibility correlations directly probe the power spectrum of HI fluctuations at the epoch when the HI emission originated, and this holds the possibility of using HI observations to study large-scale structures at high z.Comment: Submitted to JApA, 12 Latex pages including 6 figure

Variations in the slope of the psychometric functions for speech intelligibility: a systematic survey

Although many studies have looked at the effects of different listening conditions on the intelligibility of speech, their analyses have often concentrated on changes to a single value on the psychometric function, namely, the threshold. Far less commonly has the slope of the psychometric function, that is, the rate at which intelligibility changes with level, been considered. The slope of the function is crucial because it is the slope, rather than the threshold, that determines the improvement in intelligibility caused by any given improvement in signal-to-noise ratio by, for instance, a hearing aid. The aim of the current study was to systematically survey and reanalyze the psychometric function data available in the literature in an attempt to quantify the range of slope changes across studies and to identify listening conditions that affect the slope of the psychometric function. The data for 885 individual psychometric functions, taken from 139 different studies, were fitted with a common logistic equation from which the slope was calculated. Large variations in slope across studies were found, with slope values ranging from as shallow as 1% per dB to as steep as 44% per dB (median = 6.6% per dB), suggesting that the perceptual benefit offered by an improvement in signal-to-noise ratio depends greatly on listening environment. The type and number of maskers used were found to be major factors on the value of the slope of the psychometric function while other minor effects of target predictability, target corpus, and target/masker similarity were also found

Skewness in the Cosmic Microwave Background Anisotropy from Inflationary Gravity Wave Background

In the context of inflationary scenarios, the observed large angle anisotropy of the Cosmic Microwave Background (CMB) temperature is believed to probe the primordial metric perturbations from inflation. Although the perturbations from inflation are expected to be gaussian random fields, there remains the possibility that nonlinear processes at later epochs induce ``secondary'' non-gaussian features in the corresponding CMB anisotropy maps. The non-gaussianity induced by nonlinear gravitational instability of scalar (density) perturbations has been investigated in existing literature. In this paper, we highlight another source of non-gaussianity arising out of higher order scattering of CMB photons off the metric perturbations. We provide a simple and elegant formalism for deriving the CMB temperature fluctuations arising due to the Sachs-Wolfe effect beyond the linear order. In particular, we derive the expression for the second order CMB temperature fluctuations. The multiple scattering effect pointed out in this paper leads to the possibility that tensor metric perturbation, i.e., gravity waves (GW) which do not exhibit gravitational instability can still contribute to the skewness in the CMB anisotropy maps. We find that in a flat $\Omega =1$ universe, the skewness in CMB contributed by gravity waves via multiple scattering effect is comparable to that from the gravitational instability of scalar perturbations for equal contribution of the gravity waves and scalar perturbations to the total rms CMB anisotropy. The secondary skewness is found to be smaller than the cosmic variance leading to the conclusion that inflationary scenarios do predict that the observed CMB anisotropy should be statistically consistent with a gaussian random distribution.Comment: 10 pages, Latex (uses revtex), 1 postscript figure included. Accepted for publication in Physical Review

Retrospective analysis of necropsy findings in patients of H1N1 and their correlation to clinical features

India reported its first case of H1N1 in July 2009 in Pune and since then, the number of reported cases and deaths exploded in India. Since very little data is available about histopathological findings in patients of H1N1 fatal cases in India, a retrospective chart analysis of necropsy findings of 15 cases of 2009 H1N1 fatal cases was performed. Common clinical features were fever, cough , and breathlessness followed by sore throat and rhinorrhea. Common lung findings were mononuclear cell infiltration, thick alveolar septae, intraalveolar hemorrhage . The other findings were congested pulmonary blood vessels, pulmonary edema, cytomegaly, fibrin accumulation and formation of eosinophilic membrane. These findings are suggestive of diffuse alveolar damage ( DAD) and DAD with hemorrhage. All patients who underwent necropsy had radiographic findings suggestive of unilobar or multilobar pneumonia. This clinical finding can be correlated pathologically in these patients as all of them had either polymorphonuclear or mononuclear infiltrate. Furthermore, necrotizing pneumonitis pattern seen on these patients is the likely cause of mortality in these patients. Although clinical ARDS pattern was noted in all these patients, it was well correlated in lung pathology in all these cases