Un tarif de tonlieu inconnu, institué par le comte de Flandre Thierry d'Alsace (1128-1168) pour le port de <i>Littersuerua</i>, précurseur du port de Damme

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Advances in cardiovascular research. 15th Annual Meeting of the European Council for Cardiovascular Research (ECCR). La Colle sur Loup, France, 8-10 October 2010

The 15th Annual Meeting of the European Council of Cardiovascular Research brought together basic and clinical scientists working in the cardiovascular field in La Colle sur Loup, France. Upfront basic and clinical research addressing the mechanisms of disease, identification of biomarkers or development of new treatments was communicated in 101 presentations, 35 of them as a part of five on-topic oral sessions and three workshops. Three keynote lectures reviewed current knowledge and the latest data about mechanosensitive channels in pressure regulation, cell therapy in cardiovascular disease and mechanisms of cardiovascular risk associated with diabetic nephropathy. This article summarizes highlights of the oral sessions, workshops and keynote lectures

Insight into the dynamics of a long-runout mass movement using single-grain feldspar luminescence in the Pokhara Valley, Nepal

Mass movements play an important role in landscape evolution of high mountain areas such as the Himalayas. Yet, establishing numerical age control and reconstructing transport dynamics of past events is challenging. To fill this research gap, we bring luminescence dating to the test in an extremely challenging environment: the Pokhara Valley in Nepal. This is challenging for two reasons: (i) the optically stimulated luminescence (OSL) sensitivity of quartz, typically the mineral of choice for dating sediments younger than 100 ka, is poor, and (ii) highly rapid and turbid conditions during mass movement transport hamper sufficient OSL signal resetting prior to deposition, which eventually results in age overestimation. Here, we first assess the applicability of single-grain feldspar dating of medieval mass movement deposits catastrophically emplaced in the Pokhara Valley. Second, we exploit the poor bleaching mechanisms to get insight into the sediment dynamics of this paleo-mass movement through bleaching proxies. The Pokhara Valley is a unique setting for our case study, considering the availability of an extensive independent radiocarbon dataset as a geochronological benchmark. Single-grain infrared stimulated luminescence (IRSL) signals were measured at 50 ∘C (IRSL-50) and post-infrared infrared stimulated luminescence signals at 150 ∘C (pIRIR-150). Our results show that the IRSL-50 signal is better bleached than the pIRIR-150 signal. A bootstrapped minimum age model (bMAM) is applied to retrieve the youngest subpopulation to estimate the paleodose. However, burial ages calculated with this paleodose overestimate the radiocarbon ages by an average factor of ∼23 (IRSL-50) and ∼72 (pIRIR-150), showing that dating of the Pokhara Formation with a single-grain approach was not successful for most samples. Some samples, however, only slightly overestimate the true emplacement age and thus could be used for a rough age estimation. Large inheritances in combination with the scatter in the single-grain dose distributions show that the sediments have been transported under extremely limited light exposure prior to deposition, which is consistent with the highly turbid nature of the sediment-laden flood and debris flows depositing the Pokhara gravels. To investigate the sediment transport dynamics in more detail, we studied three bleaching proxies: the percentage of grains in saturation 2D0 criteria, the percentage of best-bleached grains (2σ range of bMAM-De) and the overdispersion (OD). None of the three bleaching proxies indicate a spatial relationship with runout distance of the mass movement deposits. We interpret this as evidence for the lack of bleaching during transport, which reflects the catastrophic nature of the event. While not providing reliable burial ages of the Pokhara mass movement deposits, single-grain feldspar dating can potentially be used as an age range finder method. Our approach shows the potential of luminescence techniques to provide insights in sediment transport dynamics of extreme and rare mass movement events in mountainous regions.</p

Differential bleaching of quartz and feldspar luminescence signals under high-turbidity conditions

Sediment burial dating using optically stimulated luminescence (OSL) is a well-established tool in geochronology. An important but often inapplicable requirement for its successful use is that the OSL signal is sufficiently reset prior to deposition. However, subaqueous bleaching conditions during fluvial transport are vastly understudied; for example the effect of turbidity and sediment mixing on luminescence bleaching rates is only poorly established. The possibility that slow bleaching rates may dominate under certain transport conditions led to the concept that OSL could be used to derive sediment transport histories. The feasibility of this concept is still to be demonstrated, and experimental set-ups are still to be tested. Our contribution to this scientific challenge involves subaquatic bleaching experiments, in which we suspend saturated coastal sand of Miocene age in a circular flume and illuminate it for discrete time intervals with natural light. We record the in situ energy flux density received by the suspended grains in the UV-NIR frequency range by using a broadband spectrometer with a submersible probe. Our analysis includes pre-profiling of each sample following a polymineral multiple signal (PMS) protocol. Using the PMS, the quartz-dominated, blue-stimulated luminescence signal at 125 ∘C (BSL-125) decays slower than the K-feldspar-dominated, infrared-stimulated luminescence signal at 25 ∘C (IR-25) even under subaerial conditions. The BSL-125 from purified quartz shows the opposite behaviour, which renders the PMS unreliable in our case. We find a negative correlation between suspended-sediment concentration and bleaching rate for all the measured signals. For outdoor bleaching experiments we propose to relate the measured luminescence dose to the cumulative received irradiance rather than to the bleaching time. Increases in the sediment concentration lead to a stronger attenuation of the UV–blue compared to the red–NIR wavelength. This attenuation thereby follows an exponential decay that is controlled by the sediment concentration and a wavelength-dependent decay constant, λ. As such λ could potentially be used in numerical models of luminescence signal resetting in turbid suspensions.</p

Unilateral sight loss in a 4-year-old girl

For 6 weeks the parents of a 4-year-old girl had noticed a difference between the two eyes of their child. Ophtalmological examination revealed leukocoria. This finding raised clinical suspicion of retinoblastoma. MRI was performed. On T2 weighted images a hypointense mass relative to the vitreous humor was evident. There were several hypointensities compatible with calcifications. An area of retinal detachment was also seen. On T1 weighted images a mildly hyperintense mass relative to vitreous humor was seen. It showed marked contrast enhancement. On diffusion weighted images there was restricted diffusion suggestive for a tumoral lesion. The imaging findings were compatible with a retinoblastoma without transscleral or optic nerve extension. The tumor was complicated by retinal detachment reducing visual potential. The patient was treated with enucleation of the affected eye

THE INITIATION OF BINOCULAR RIVALRY

Binocular rivalry refers to the perceptual alternation that occurs while viewing incompatible images, in which one monocular image is dominant and the other is suppressed. Rivalry has been closely studied but the neural site at which it is initiated is still controversial. The central claim of this thesis is that primary visual cortex is responsible for its initiation. This claim is supported by evidence from four experimental studies. The first study (described in Chapter 4) introduces the methodology for measuring visual sensitivity during dominance and suppression and compares several methods to see which yields the greatest difference between these two sensitivities. Suppression depth was measured by comparing the discrimination thresholds to a brief test stimulus delivered during dominance and suppression phases. The deepest suppression was achieved after a learning period, with the test stimulus presented for 100 ms and with post-test masking. The second study (Chapter 5) compares two hypotheses for the mechanism of binocular rivalry. Under eye suppression, visibility decreases when the tested eye is being suppressed, regardless of the test stimulus’s features. Feature suppression, however, predicts that reduction of visibility is caused by suppression of a stimulus feature, no matter which eye is suppressed. Eye suppression claims that monocular channels in the visual system alternate between dominance and suppression, while Feature suppression assumes that the features of stimuli inhibit each other perceptually in the high-level cortex. The experiment used a test stimulus similar in features to one, but not the other, rivalry-inducing stimulus. Test sensitivity was found to be lowered when the test stimulus was presented to the eye whose rivalry-inducing stimulus was suppressed. Sensitivity was not lowered when the test stimulus was presented to the other eye, even when the test shared features with the suppressed stimulus. The conclusion is that feature suppression is weak or does not exist without eye suppression, and that rivalry therefore originates in the primary visual cortex. If binocular rivalry is initiated in the primary visual cortex, stimuli producing no coherent activity in that area should produce no rivalry. In the third study (Chapter 6) this idea was tested with rotating arrays of short-lifetime dots. The dots with the shortest lifetime produced an image with no rotation signal, and an infinite lifetime produced rigid rotation. Subjects could discriminate the rotation direction with high accuracy at all but the shortest lifetime. When the two eyes were presented with opposite directions of rotation, there was binocular rivalry only at the longest lifetimes. Stimuli with short lifetimes produce a coherent motion signal, since their direction can be discriminated, but do not produce rivalry. A simple interpretation of this observation is that binocular rivalry is initiated at a level in the visual hierarchy below that which supports the motion signal. The model supported by the results of previous chapters requires that binocular rivalry suppression be small in the primary visual cortex, and builds up as signals progress along the visual pathway. This model predicts that for judgements dependent on activity in high visual cortex: 1. Binocular rivalry suppression should be deep; 2. Responses should be contrast invariant. The fourth and last study (chapter 7) confirmed these predictions by measuring suppression depth in two ways. First, two similar forms were briefly presented to one eye: the difference in shapes required for their discrimination was substantially greater during suppression than during dominance. Second, the two forms were made sufficiently different in shape to allow easy discrimination at high contrast, and the contrast of these forms was lowered to find the discrimination threshold. The results in the second experiment showed that contrast sensitivity did not differ between the suppression and dominance states. This invariance in contrast sensitivity is interpreted in terms of steep contrast-response functions in cortex beyond the primary visual area. The work in this thesis supports the idea that binocular rivalry is a process distributed along the visual pathway. More importantly, the results provide several lines of evidence that binocular rivalry is initiated in primary visual cortex

Variational assimilation of Lagrangian data in oceanography

We consider the assimilation of Lagrangian data into a primitive equations circulation model of the ocean at basin scale. The Lagrangian data are positions of floats drifting at fixed depth. We aim at reconstructing the four-dimensional space-time circulation of the ocean. This problem is solved using the four-dimensional variational technique and the adjoint method. In this problem the control vector is chosen as being the initial state of the dynamical system. The observed variables, namely the positions of the floats, are expressed as a function of the control vector via a nonlinear observation operator. This method has been implemented and has the ability to reconstruct the main patterns of the oceanic circulation. Moreover it is very robust with respect to increase of time-sampling period of observations. We have run many twin experiments in order to analyze the sensitivity of our method to the number of floats, the time-sampling period and the vertical drift level. We compare also the performances of the Lagrangian method to that of the classical Eulerian one. Finally we study the impact of errors on observations.Comment: 31 page

A cost effeciency approach to universal access for public transport for disabled people

Purpose To determine the intervendor variability of Agatston scoring determined with state-of-the-art computed tomographic (CT) systems from the four major vendors in an ex vivo setup and to simulate the subsequent effects on cardiovascular risk reclassification in a large population-based cohort. Materials and Methods Research ethics board approval was not necessary because cadaveric hearts from individuals who donated their bodies to science were used. Agatston scores obtained with CT scanners from four different vendors were compared. Fifteen ex vivo human hearts were placed in a phantom resembling an average human adult. Hearts were scanned at equal radiation dose settings for the systems of all four vendors. Agatston scores were quantified semiautomatically with software used clinically. The ex vivo Agatston scores were used to simulate the effects of different CT scanners on reclassification of 432 individuals aged 55 years or older from a population-based study who were at intermediate cardiovascular risk based on Framingham risk scores. The Friedman test was used to evaluate overall differences, and post hoc analyses were performed by using the Wilcoxon signed-rank test with Bonferroni correction. Results Agatston scores differed substantially when CT scanners from different vendors were used, with median Agatston scores ranging from 332 (interquartile range, 114-1135) to 469 (interquartile range, 183-1381; P < .05). Simulation showed that these differences resulted in a change in cardiovascular risk classification in 0.5\%-6.5\% of individuals at intermediate risk when a CT scanner from a different vendor was used. Conclusion Among individuals at intermediate cardiovascular risk, state-of the-art CT scanners made by different vendors produced substantially different Agatston scores, which can result in reclassification of patients to the high- or low-risk categories in up to 6.5\% of cases. © RSNA, 2014