Scattering theory for arbitrary potentials

The fundamental quantities of potential scattering theory are generalized to accommodate long-range interactions. New definitions for the scattering amplitude and wave operators valid for arbitrary interactions including potentials with a Coulomb tail are presented. It is shown that for the Coulomb potential the generalized amplitude gives the physical on-shell amplitude without recourse to a renormalization procedure.Comment: To be published in Phys Rev

Catechin production in cultured cells of Taxus cuspidata and Taxus baccata

Abstract The main polyphenols in callus and cell suspension cultures of Taxus cuspidata and T. baccata were (?)-catechin and (-)-epicatechin, while lignans, such as (?)-taxiresinol, (?)-isotaxiresinol, (?)-isolariciresinol and (-)-secoisolariciresinol, were present in trace amounts. T. cuspidata cells contained 1.7% (?)-catechin and 2.4% (-)-epicatechin on dry wt basis but when stimulated with methyl jasmonate produced 3.4% catechin and 5.2% epicatechin. These are the highest levels of these metabolites obtained in plant cell cultures

КЛИНИЧЕСКИЙ СЛУЧАЙ ГРАНУЛОЦИТАРНОГО АНАПЛАЗМОЗА ЧЕЛОВЕКА НА ТЕРРИТОРИИ АРХАНГЕЛЬСКОЙ ОБЛАСТИ

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Sequelae of COVID-19 at long-term follow-up after hospitalization

Aim. To assess long-term sequelae of COVID-19 in hospitalized patients at 3 to 7 months after discharge.Material and Methods. The whole of 700 patients hospitalized to the temporary COVID-19 treatment center hosted by the FSBI “National Medical Research Center of Cardiology” of the Ministry of Health of Russia from April to June 2020 were invited to participate in a follow-up study. At 3-7 months after the index hospitalization, patients or their proxies were contacted via telephone in order to obtain information on their vital status, cardiovascular and other conditions or their complications, and new hospitalizations. In addition, patients were invited to an outpatient visit under the "COVID-19-follow-up" program, encompassing physical examination and a comprehensive battery of laboratory and instrumental tests, including spirometry, chest computed tomography (CT) and the six minute walk test (6MWT). Further, dyspnea was assessed using the mMRC (Modified Medical Research Council) Dyspnea Scale. Results: We were able to contact 87.4% (612/700) of patients or their proxies. At follow-up, 4.4% (27) patients died, of which 96.3% (26) had cardiovascular diseases (CVD). A total of 213 patients aged 19 to 94 years old (mean age 56.8±12.5, median 57 years [49.0; 64.0]; men, 55.4%) agreed come for an outpatient visit and to participate in the “COVID-19-follow-up” program. Since discharge, 8% (17) of patients required new hospitalizations, and more than a half of these patients (58.8%; 10/17) had CVD-related hospitalizations. A total of 8.4% (18) patients experienced worsening of hypertension, 9 (4.2%) patients had newly diagnosed hypertension, 2 (0.9%) – coronary artery disease patients experienced new/recurrent angina symptoms. 4 (1.9%) patients had newly diagnosed coronary artery disease, and one patient had an ischemic stroke. At the outpatient visit, 114 (53.5%) patients had some symptoms, most frequently, shortness of breath (33%), fatigue (27.4%), chest pain (11.3%), and abnormal heartbeats (8.5%). Based on the mMRC Scale, 59% of patients had dyspnea of varying severity. Most patients had a normal vital capacity (VC), which was moderately reduced in 3.3% and severely reduced in 0.5% of patients. Chest CT scans were obtained in 78 (36.6%) patients, whose worst lung damage scores during hospitalization were CT3 or CT4. One in ten patients (10.8%) with severe lung damage during acute infection had persisting ground glass opacities, 35.9% developed fibrotic changes, 79.6% of patients had linear or fine focal opacities. According to the 6MWT data, 12.3% of patients walked less than 70% of the predicted distance, 67% walked 71 to 99% of the predicted distance, and 20.7% of patients were able to walk 100% of their predicted distance.Conclusion. These data suggest long-term negative sequelae of COVID-19 in more than half of hospitalized patients

КЛИНИЧЕСКИЙ СЛУЧАЙ СИНДРОМА МИЛЛЕРА - ФИШЕРА В ПРАКТИКЕ ДЕТСКИХ ИНФЕКЦИОННЫХ БОЛЕЗНЕЙ

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СУБТРАКЦИОННАЯ КТ-АНГИОПУЛЬМОНОГРАФИЯ В ДИАГНОСТИКЕ ХРОНИЧЕСКОЙ ТРОМБОЭМБОЛИЧЕСКОЙ ЛЕГОЧНОЙ ГИПЕРТЕНЗИИ

Purpose. To assess the state of the vascular bed and perfusion of the lungs in patients with chronic thromboembolic pulmonary hypertension (CTEPH) by the method of subtraction computed tomography (CT).Materials and methods. Between November 2015 and May 2018, 65 patients with diagnosis of CTEPH were examined. All patients were examined on a computer tomograph Aquilion ONE 640 VISION Edition (Toshiba Medical Systems) with 320 rows of detectors, slice thickness – 0,5 mm. Assessment of perfusion disorders was carried out using new software, which allows combining contrast and noncontrast images by subtraction. Were analyzed parameters of the parenchyma, blood supply and perfusion status with the calculation of indices of obstruction and perfusion disorders. The obstruction index was compared with the index of perfusion abnormalities, a 6-minute walk test, and mean pulmonary artery pressure according to the right heart catheterization data. Results. The significant correlation was found between the obstruction index and the index of perfusion disorders in patients with CTEPH (r = 0.605; p = 0.000001). Interrelations between vascular-perfusion indices (an obstruction index and an index of perfusion disorders), mean pulmonary artery pressure and distance in a 6-minute walk test were not revealed.Conclusion. Subtraction CT pulmonary angiography allows to assess the severity of vascular lesion and perfusion disorders within a single study, also determine the effectiveness of treatment in patients with CTEPH.Цель исследования: оценить состояние сосудистого русла и перфузии легких у больных хронической тромбоэмболической легочной гипертензией (ХТЭЛГ) методом субтракционной компьютерной томографии (КТ).Материал и методы. В период с ноября 2015 г. по май 2018 г. было обследовано 65 пациентов с диагнозом ХТЭЛГ. Все пациенты были обследованы на компьютер-ном томографе Aquilion ONE 640 VISION Edition (Toshiba Medical Systems) с 320 рядами детекторов, толщина томографического среза 0,5 мм. Оценка перфузионных нарушений выполнялась с помощью нового программного обеспечения, которое позволяет совмещать контрастные и бесконтрастные изображения методом субтракции. Анализировались параметры состояния паренхимы, кровоснабжения и перфузии легких с расчетом индексов обструкции и перфузионных нарушений. Индекс обструкции был сопоставлен с индексом перфузионных нарушений, тестом 6-минутной ходьбы (Т6МХ) и средним давлением в легочной артерии (ср. ДЛА) по данным катетеризации правых отделов сердца.Результаты. Между индексом обструкции и индексом перфузионных нарушений у больных ХТЭЛГ была обнаружена статистически значимая корреляция (r = 0,605; p = 0,000001). Взаимосвязей между сосудисто-перфузионными показателями (индексом обструкции и индексом перфузионных нарушений), ср.ДЛА и пройденной дистанцией в Т6МХ выявлено не было.Заключение. Использование субтракционной КТ-ангиопульмонографии позволяет оценить выраженность сосудистого поражения и перфузионных нарушений в рамках одного исследования, а также определить эффективность лечения у пациентов с ХТЭЛГ

СОПОСТАВЛЕНИЕ РЕЗУЛЬТАТОВ КОМПЬЮТЕРНОЙ ТОМОГРАФИИ И ВНУТРИСОСУДИСТОГО УЛЬТРАЗВУКОВОГО ИССЛЕДОВАНИЯ В ОЦЕНКЕ ПАРАМЕТРОВ АТЕРОСКЛЕРОТИЧЕСКИХ БЛЯШЕК КОРОНАРНЫХ АРТЕРИЙ

Purpose. To determine the possibilities of coronary CT-angiography (CTA) in evaluation of qualitative and qualitative parameters of coronary plaques in comparison with intravascular ultrasound (IVUS).Matherials and methods. 37 patients (29 men, 8 women) with symptoms of acute coronary syndrome (ACS) were included in the study. Unstable angina was detected in 24 patients, acute myocardial infarction (AMI) – in 13 patients. Averageage was 58 [44; 65] years. CTA had been performed as the first method of beam diagnostics in all cases if it was not necessary to use the emergency selective coronary angiography (CAG). IVUS was performed in one, two or three coronary arteries of every patient. Total, 60 coronary lesionsin 55 arteries were examined with IVUS. IVUS data was compared with CTA data.Results. Methods well correlated in detection of plaque burden (r = 0.823; p < 0.0001), plaque length (r = 0.932, p < 0.0001), remodeling index(RI) (r = 0.906; p < 0.0001). Sensitivity and specificity of CTA in detection of irregular contour was 96.1% and 88.9% (area under ROC-curve 0.925), positive remodeling – 100% and 97.4% (area under ROC-curve 0.974). CTA and IVUS in evaluation of spotty calcinates was not coincide in 9 plaques, sensitivity and specificity of CTA in detection of 71% and 100% (area under ROC-curve 0.855).Discussion. Comparison of CTA and IVUS was performed in evaluation of plaques features in patients with ACS. This analysis showed high comparability of methods for evaluation of coronary stenosis degree, RI, plaque burden, length and contour. Thus, the characteristics of plaques according to CTA data can be used to stratify the risk of development of ACS.Conclusion. CTA – fast non-invasive method of coronary plaques evaluation. CTA correlates well with IVUS.Цель исследования: определить возможности КТ-ангиографии (КТА) в оценке количественных и качественных характеристик атеросклеротических бляшек (АСБ) в коронарных артериях по сравнению с данными внутрисосудистого ультразвукового исследования (ВСУЗИ).Материал и методы. В исследование было включено 37 пациентов (29 мужчин, 8 женщин), поступивших в отделение неотложной кардиологии с клинической картиной острого коронарного синдрома (ОКС), из которых у 24 диагностирована нестабильная стенокардия, у 13 – острый инфаркт миокарда. Средний возраст больных составил 58 [44; 65] лет. Всем пациентам первым из лучевых методов исследования была выполнена КТА коронарных артерий при отсутствии необходимости экстренного проведения инвазивной коронарной ангиографии. Каждому из 37 пациентов ВСУЗИ было выполнено в одной, двух или трех коронарных артериях. Всего с помощью ВСУЗИ обследовано 60 измененных участков в 55 коронарных артериях. Данные ВСУЗИ сравнивались с результатами КТА.Результаты. Корреляционный анализ показал высокую сопоставимость методов в определении бремени бляшки (r = 0,823; p < 0,0001), протяженности бляшки (r = 0,932; p < 0,0001), индекса ремоделирования (ИР) (r = 0,906; p < 0,0001). Чувствительность и специфичность метода в выявлении неровности контура составили 96,1 и 88,9% (площадь под кривой 0,925), положительного ремоделирования – 100 и 97,4% (площадь под кривой 0,974) соответственно. При оценке точечных кальцинатов в 9 мягких бляшках данные КТА не совпадали с данными ВСУЗИ. а чувствительность и специфичность метода составили 71 и 100% (площадь под кривой 0,855) соответственно.Обсуждение. В представленной работе впервые в нашей стране проведен сравнительный анализ состояния бляшек в коронарных артериях по данным КТА и ВСУЗИ у больных с ОКС, который показал высокую сопоставимость методов для определения степени стенозирования просвета коронарных артерий, ИР, бремени, протяженности и контуров бляшки. Таким образом, характеристики АСБ по данным КТА можно использовать для стратификации риска развития ОКС.Заключение. КТА является быстрым неинвазивным методом оценки состояния АСБ. Результаты КТА хорошо коррелируют с данными ВСУЗИ

2020 Clinical practice guidelines for Pulmonary hypertension, including chronic thromboembolic pulmonary hypertension

Russian Society of Cardiology (RSC)With the participation: Association of Cardiovascular Surgeons of Russia, Russian Respiratory Society, Federation of Anesthesiologists and Resuscitators, Association of Rheumatologists of Russia, National Congress of Radiation Diagnosticians

New approach to phase and modulation resolved spectra

Time domain fluorescence spectrometry offers a versatile and powerful approach to the analysis of heterogeneous emitting systems. In this paper we describe a new approach, based on software, to the acquisition of phase and modulation resolved spectra. Mixtures of fluorophores with different lifetimes can be analyzed in real time to give the individual excitation or emission spectra. Examples of two- and three-component mixtures are given and comparisons are made with the commercially available hardware approach. © 1985, American Chemical Society. All rights reserved