Compared to What? Is BMI Associated with Histopathological Changes in Laparoscopic Sleeve Gastrectomy Specimens?

Background: Obesity is a risk for many different cancers. Laparoscopic sleeve gastrectomy (LSG) is common, and benign or pre-malignant histopathology types are reported in the removed gastric specimens. We assessed whether higher BMI was associated with certain benign or pre-malignant histopathological changes. Method: Retrospective chart review of all primary LSG patients (N = 1555). Demographic, clinical, and LSG histopathology data were retrieved. BMI of patients with specific benign or pre-malignant conditions in their gastric specimens was compared with the BMI of the rest of the patients with abnormal histopathology specimens and also compared with the BMI of patients with normal control specimens. Results: Females comprised 70% of the patients. Mean BMI were 46.3 (females) and 48 (males). Normal LSG specimens comprised 52%. Most common abnormal histopathologies were chronic inactive gastritis (33%), chronic active gastritis (6.8%), follicular gastritis (2.7%), lymphoid aggregates (2.2%), intestinal metaplasia (1.4%) and GIST (0.7%). After controlling for confounders (age, gender, H. pylori, diabetes mellitus type 2, hypertension), no significant association was observed between the BMI of patients with specific benign or pre-malignant histopathology compared with the BMI of the rest of the patients with abnormal histopathologies and compared to the BMI of patients with normal histopathologies. Conclusion: When confounders were taken into account, there appeared no significant associations between the BMI of patients with specific benign or pre-malignant histopathology compared with the BMI of the rest of the patients with abnormal histopathologies and compared to the BMI of patients with normal histopathologies of their gastric specimens. There was a very weak correlation between BMI and other covariates. - 2019, The Author(s).Acknowledgements Open Access funding provided by the Qatar National Library. The authors wish to thank Dr. Prem Chandra for assistance with the statistical analysis and the Medical Research Center at HMC for their support for the current study.Scopu

A contact-based social network of lizards is defined by low genetic relatedness among strongly connected individuals

Author version made available in accordance with the Publisher's policy, after an embargo period of 24 months from the date of publication. © 2015. Licensed under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/Social organization is widespread; even largely solitary species must organize themselves to enable contacts with mates and reduce competition with conspecifics. Although the forms of social structure can be subtle in solitary species, understanding the factors that influence them may be important for understanding how different forms of social organization evolved. We investigated the influence of genetic relatedness and spatial structure on social associations in a solitary living Australian scincid lizard, Tiliqua rugosa. We derived the genetic relatedness of 46 lizards from analysis of genotypes at 15 microsatellite DNA loci, and described social networks from GPS locations of all the lizards every 10 min for 81 days during their main activity period of the year. We found that connected male dyads were significantly more related than expected by chance, whereas connected male–female and female–female dyads had lower relatedness than expected. Among neighbouring male–male and male–female dyads, the strongest social relationships were between lizards that were the least related. Explanations of this pattern may include the avoidance of inbreeding in male–female dyads, or the direction of aggressive behaviour towards less related individuals in male–male dyads. Observed social associations (inferred through synchronous spatial proximity) were generally lower than expected from null models derived from home range overlap, and many close neighbours did not make social contact. This supports our hypothesis for the presence of deliberate avoidance between some neighbouring individuals. We suggest that lizards can discriminate between different levels of relatedness in their neighbours, directing their social interactions towards those that are less related. This highlights differences in how social associations are formed between species that are solitary (where associations form between unrelated conspecifics) and species that maintain stable social groups structured by kinship.Our sleepy lizard research was funded by the Australian Research Council

Biodiesel production from Cannabis sativa oil from Pakistan

The present study was appraised using response surface methodology for process optimization owing to strong interaction of reaction variables: NaOCH3 catalyst concentration (0.25–1.50%), methanol/oil molar ratio (3:1–9:1), reaction time (30–90 min), and reaction temperature (45–65°C). The quadratic polynomial equation was determined using response surface methodology for predicting optimum methyl esters yield from Cannabis sativa oil. The analysis of variance results indicated that molar ratio and reaction temperature were the key factors that appreciably influence the yield of Cannabis sativa oil methyl esters. The significant (p < 0.0001) variable interaction between molar ratio × catalyst concentration and reaction time × molar ratio was observed, which mostly affect the Cannabis sativa oil methyl esters yield. The optimum Cannabis sativa oil methyl esters yield, i.e., 86.01% was gained at 53°C reaction temperature, 7.5:1 methanol/oil molar ratio, 65 min reaction time, and 0.80% catalyst concentration. The results depicted a linear relationship between observed and predicted values. The residual analysis predicted the appropriateness of the central composite design. The Cannabis sativa oil methyl esters, analyzed by gas chromatography, elucidated six fatty acid methyl esters (linoleic, α-linolenic, oleic, palmitic, stearic, and γ-linolenic acids). In addition, the fuel properties, such as kinematic viscosity at 40°C; cetane number; acid value; flash point; cloud, pour, and cold filter plugging points; ash content; density; and sulphur content, of Cannabis sativa oil methyl esters were evaluated and discussed with reference to ASTM D 6751 and EU 14214 biodiesel specifications

Microlensing toward crowded fields: Theory and applications to M31

We present a comprehensive treatment of the pixel-lensing theory and apply it to lensing experiments and their results toward M31. Using distribution functions for the distances, velocities, masses, and luminosities of stars, we derive lensing event rates as a function of the event observables. In contrast to the microlensing regime, in the pixel-lensing regime (crowded or unresolved sources) the observables are the maximum excess flux of the source above a background and the full width at half-maximum (FWHM) time of the event. To calculate lensing event distribution functions depending on these observables for the specific case of M31, we use data from the literature to construct a model of M31, reproducing consistently photometry, kinematics and stellar population. We predict the halo- and self-lensing event rates for bulge and disk stars in M31 and treat events with and without finite source signatures separately. We use the M31 photon noise profile and obtain the event rates as a function of position, field of view, and S/N threshold at maximum magnification. We calculate the expected rates for WeCAPP and for a potential Advanced Camera for Surveys (ACS) lensing campaign. The detection of two events with a peak signal-to-noise ratio larger than 10 and a timescale larger than 1 day in the WeCAPP 2000/2001 data is in good agreement with our theoretical calculations. We investigate the luminosity function of lensed stars for noise characteristics of WeCAPP and ACS. For the pixel-lensing regime, we derive the probability distribution for the lens masses in M31 as a function of the FWHM timescale, flux excess and color, including the errors of these observables.Comment: 45 pages, 27 figures LaTeX; corrected typos; published in the Astrophysical Journal Supplemen

HST Imaging of MEGA Microlensing Candidates in M31

We investigate $HST$/ACS and WFPC2 images at the positions of five candidate microlensing events from a large survey of variability in M31 (MEGA). Three closely match unresolved sources, and two produce only flux upper limits. All are confined to regions of the color-magnitude diagram where stellar variability is unlikely to be easily confused with microlensing. Red variable stars cannot explain these events (although background supernova are possible for two). If these lenses arise in M31's halo, they are due to masses $0.15 < m / M_\odot < 0.49$ (95% certainty, for a $\delta$-function mass distribution), brown dwarfs for disk lenses, and stellar masses for bulge lenses.Comment: Accepted for publication in ApJL. Higher resolution version available at http://www.astro.columbia.edu/~patrick/hst/hst_ml.pd