Star formation in a diffuse high-altitude cloud?

A recent discovery of two stellar clusters associated with the diffuse high-latitude cloud HRK 81.4-77.8 has important implications for star formation in the Galactic halo. We derive a plausible distance estimate to HRK 81.4-77.8 primarily from its gaseous properties. We spatially correlate state-of-the-art HI, far-infrared and soft X-ray data to analyze the diffuse gas in the cloud. The absorption of the soft X-ray emission from the Galactic halo by HRK 81.4-77.8 is used to constrain the distance to the cloud. HRK 81.4-77.8 is most likely located at an altitude of about 400 pc within the disk-halo interface of the Milky Way Galaxy. The HI data discloses a disbalance in density and pressure between the warm and cold gaseous phases. Apparently, the cold gas is compressed by the warm medium. This disbalance might trigger the formation of molecular gas high above the Galactic plane on pc to sub-pc scales.Comment: 6 pages, 4 figures, accepted for publication in Astronomy & Astrophysic

Chiral Condensate and Short-Time Evolution of QCD(1+1) on the Light-Cone

Chiral condensates in the trivial light-cone vacuum emerge if defined as short-time limits of fermion propagators. In gauge theories, the necessary inclusion of a gauge string in combination with the characteristic light-cone infrared singularities contain the relevant non-perturbative ingredients responsible for formation of the condensate, as demonstrated for the 't Hooft model.Comment: 4 pages, Revtex

Parsummable categories as a strictification of symmetric monoidal categories

We prove that the homotopy theory of parsummable categories (as defined by Schwede) with respect to the underlying equivalences of categories is equivalent to the usual homotopy theory of symmetric monoidal categories. In particular, this yields a model of symmetric monoidal categories in terms of categories equipped with a strictly commutative, associative, and unital (but only partially defined) operation

Polyakov Loop Dynamics in the Center Symmetric Phase

A study of the center symmetric phase of SU(2) Yang Mills theory is presented. Realization of the center symmetry is shown to result from non-perturbative gauge fixing. Dictated by the center symmetry, this phase exhibits already at the perturbative level confinement like properties. The analysis is performed by investigating the dynamics of the Polyakov loops. The ultralocality of these degrees of freedom implies significant changes in the vacuum structure of the theory. General properties of the confined phase and of the transition to the deconfined phase are discussed. Perturbation theory built upon the vacuum of ultralocal Polyakov loops is presented and used to calculate, via the Polyakov loop correlator, the static quark-antiquark potential.Comment: 45 pages, LaTeX, 8 figure

Color screening in a constituent quark model of hadronic matter

The effect of color screening on the formation of a heavy quark-antiquark ($Q\bar{Q}$) bound state--such as the $J/\psi$ meson--is studied using a constituent-quark model. The response of the nuclear medium to the addition of two color charges is simulated directly in terms of its quark constituents via a string-flip potential that allows for quark confinement within hadrons yet enables the hadrons to separate without generating unphysical long-range forces. Medium modifications to the properties of the heavy meson, such as its energy and its mean-square radius, are extracted by solving Schr\"odinger's equation for the $Q\bar{Q}$ pair in the presence of a (screened) density-dependent potential. The density dependence of the heavy-quark potential is in qualitative agreement with earlier studies of its temperature dependence extracted from lattice calculations at finite temperature. In the present model it is confirmed that abrupt changes in the properties of the $J/\psi$-meson in the hadronic medium ({\it plasma}), correlate strongly with the deconfining phase transition.Comment: 7 pages, 3 figures, submitted to PRC for publication, uses revtex

The Path Integral for 1+1-dimensional QCD

We derive a path integral expression for the transition amplitude in 1+1-dimensional QCD starting from canonically quantized QCD. Gauge fixing after quantization leads to a formulation in terms of gauge invariant but curvilinear variables. Remainders of the curved space are Jacobians, an effective potential, and sign factors just as for the problem of a particle in a box. Based on this result we derive a Faddeev-Popov like expression for the transition amplitude avoiding standard infinities that are caused by integrations over gauge equivalent configurations.Comment: 16 pages, LaTeX, 3 PostScript figures, uses epsf.st

Unique pathogen peptidomes facilitate pathogen-specific selection and specialization of MHC alleles

A key component of pathogen-specific adaptive immunity in vertebrates is the presentation of pathogen-derived antigenic peptides by major histocompatibility complex (MHC) molecules. The excessive polymorphism observed at MHC genes is widely presumed to result from the need to recognize diverse pathogens, a process called pathogen-driven balancing selection. This process assumes that pathogens differ in their peptidomes—the pool of short peptides derived from the pathogen’s proteome—so that different pathogens select for different MHC variants with distinct peptide-binding properties. Here, we tested this assumption in a comprehensive data set of 51.9 Mio peptides, derived from the peptidomes of 36 representative human pathogens. Strikingly, we found that 39.7\% of the 630 pairwise comparisons among pathogens yielded not a single shared peptide and only 1.8\% of pathogen pairs shared more than 1\% of their peptides. Indeed, 98.8\% of all peptides were unique to a single pathogen species. Using computational binding prediction to characterize the binding specificities of 321 common human MHC class-I variants, we investigated quantitative differences among MHC variants with regard to binding peptides from distinct pathogens. Our analysis showed signatures of specialization toward specific pathogens especially by MHC variants with narrow peptide-binding repertoires. This supports the hypothesis that such fastidious MHC variants might be maintained in the population because they provide an advantage against particular pathogens. Overall, our results establish a key selection factor for the excessive allelic diversity at MHC genes observed in natural populations and illuminate the evolution of variable peptide-binding repertoires among MHC variants