The effects of donepezil in Alzheimer's disease - Results from a multinational trial

Donepezil has been shown to be well tolerated and to improve cognition and global function in patients with mild to moderately severe Alzheimer's disease (AD). The current trial was undertaken to investigate further the efficacy and safety of donepezil, in a multinational setting, in patients with mild to moderately severe AD. This 30-week, placebo-controlled, parallel-group study consisted of a 24-week, double-blind treatment phase followed by a 6-week, single-blind, placebo washout. Eight hundred and eighteen patients with mild to moderately severe AD were randomly allocated to treatment with single, daily doses of 5 or 10 mg donepezil, or placebo. The two primary efficacy measures were: a cognitive performance test, the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) and a global evaluation, the Clinician's Interview-Based Impression of Change with caregiver input (CIBIC plus). Secondary outcome measures included the Sum of the Boxes of the Clinical Dementia Rating Scale (CDR-SB), a modified Interview for Deterioration in Daily living activities in Dementia (IDDD) and a patient-rated quality of life assessment. Statistically significant improvements in cognitive and global function were observed, as evaluated by ADAS-cog and CIBIC plus, respectively, in both the 5 and 10 mg/day donepezil groups, compared with placebo. Treatment-associated changes were also observed in functional skills, as shown by improved scores on the CDR-SB and the complex-tasks component of the IDDD. A dose-response effect was evident, with the 10 mg/day donepezil group demonstrating greater benefits in all outcome measures than the 5 mg/day group. Donepezil was well tolerated by this patient population and did not produce any clinically significant laboratory test abnormalities. The results of this study confirm that donepezil is effective and well tolerated in treating the symptoms of mild to moderately severe AD

Dynamics Explorer 2: Continued FPI and NACS instrument data analysis and associated scientific activity at the University of Michigan

The grant entitled 'Dynamics Explorer 2 - continued FPI and NACS instrument data analysis and associated scientific activity at the University of Michigan' is a continuation of a grant that began with instrument development for the Dynamics Explorer 2 (DE 2) satellite. Over the years, many publications and presentations at scientific meetings have occurred under the aegis of this grant. This present report details the progress that has been made in the final three years of the grant. In these last 4 years of the grant 26 papers have been published or are in press and about 10 more are in preparation or have been submitted. A large number of presentations have been made in the same time span: 36 are listed in Appendix 2. Evidence of the high educational utility of this research is indicated by the list of Ph. D. and M. S. theses that have been completed in the last 3 years that have involved work connected with NAG5-465. The structure of this report is as follows: a brief synopsis of the aims of the grant NAG5-465 is given in the next section; then there is a summary of the scientific accomplishments that have occurred over the grant period; last, we make some brief concluding remarks. Reprints of articles that have recently appeared in refereed journals are appended to the end of this document

Implementation of a Pulsed-Laser Measurement System in the National Transonic Facility

A remotely-adjustable laser transmission and imaging system has been developed for use in a high-pressure, cryogenic wind tunnel. Implementation in the National Transonic Facility has proven the system suitable for velocity and signal lifetime measurements over a range of operating conditions. The measurement system allows for the delivery of high-powered laser pulses through the outer pressure shell and into the test section interior from a mezzanine where the laser is free from environmental disturbances (such as vibrations and excessive condensation) associated with operation of the wind tunnel. Femtosecond laser electronic excitation tagging (FLEET) was utilized to provide freestream velocity measurements, and first results show typical data that may be obtained using the system herein described

Chandra Observation of the Cluster Environment of a WAT Radio Source in Abell 1446

Wide-angle tail (WAT) radio sources are often found in the centers of galaxy clusters where intracluster medium (ICM) ram pressure may bend the lobes into their characteristic C-shape. We examine the low redshift (z=0.1035) cluster Abell 1446, host to the WAT radio source 1159+583. The cluster exhibits possible evidence for a small-scale cluster-subcluster merger as a cause of the WAT radio source morphology. This evidence includes the presence of temperature and pressure substructure along the line that bisects the WAT as well as a possible wake of stripped interstellar material or a disrupted cool core to the southeast of the host galaxy. A filament to the north may represent cool, infalling gas that's contributing to the WAT bending while spectroscopically determined redshifts of member galaxies may indicate some component of a merger occurring along the line-of-sight. The WAT model of high flow velocity and low lobe density is examined as another scenario for the bending of 1159+583. It has been argued that such a model would allow the ram pressure due to the galaxy's slow motion through the ICM to shape the WAT source. A temperature profile shows that the cluster is isothermal (kT= 4.0 keV) in a series of annuli reaching a radius of 400 kpc. There is no evidence of an ongoing cooling flow. Temperature, abundance, pressure, density, and mass profiles, as well as two-dimensional maps of temperature and pressure are presented.Comment: 40 AASTeX pages including 15 postscript figures; accepted for publication in Ap

A Compact EMAT Receiver for Ultrasonic Testing at Elevated Temperatures

For the past several years, the AISI and several national laboratories have cooperated on a program to develop ultrasonic transducers that can be used in steel mills at the highest temperatures encountered during the processing of the solid metal {1}. To date, pulsed laser light focused on the surface appears to make a satisfactory generator or transmitter for ultrasonic pulses while the EMAT or Electromagnetic Acoustic Transducer appears to hold the greatest promise for the receiver {2}. Both of these essentially noncontact devices can be made to withstand the very hot environmnent and they are not very sensitive to the quality of the surface

A Comparison of Radio and X-Ray Morphologies of Four Clusters of Galaxies Containing Radio Halos

Clusters of galaxies may contain cluster-wide, centrally located, diffuse radio sources, called halos. They have been found to show morphologies similar to those of the X-ray emission. To quantify this qualitative statement we performed a point-to-point comparison of the radio and the X-ray emission for four clusters of galaxies containing radio halos: Coma, Abell 2255, Abell 2319, Abell 2744. Our study leads to a linear relation between the radio and the X-ray surface brightness in two clusters, namely Abell 2255 and Abell 2744. In Coma and A2319 the radio and the X-ray brightnesses seem to be related with a sub-linear power law. Implications of these findings within simple radio halo formation models are briefly discussed.Comment: 9 pages, 13 .ps figures, accepted by A&

Three Navigation Systems With Three Tasks: Using the Lane-Change Test (LCT) to Assess Distraction Demand

The Lane Change Test (ISO, 2008; Mattes, 2003) was used to assess distraction demand when drivers completed three typical navigation tasks (an easy navigation task, a point of interest task and a difficult navigation task) using three different navigation systems. In order for the LCT to be a useful procedure, it must distinguish good from poor navigation systems and acceptable from unacceptable tasks performed using those systems. The results provide some general support for the LCT as a sensitive measure of distraction. Some aspects of the results, however, called into question the adequacy of the LCT as a sufficient measure of distraction. In particular, the LCT was found to be insensitive to task demands arising from excessive task duration. Since risk exposure is a function of secondary task duration (as well as other factors such as intensity, frequency and timing), it is recommended that a measure of task duration be incorporated in the LCT procedure. When the MDEV was modified to incorporate task duration, the resulting measure (mean deviation per average task) reflected more adequately the interaction demands of the various navigation tasks

An event study to provide validation of TING and CMIT geomagnetic middle-latitude electron densities at the F2 peak

[1] The coupled thermosphere-ionosphere magnetosphere (CMIT) model and the Thermosphere Ionosphere Nested Grid (TING) model have been run to simulate the 15 May 1997 interplanetary coronal mass ejection\u27s (ICME) effects on the Earth\u27s ionosphere and thermosphere. Comparisons were made between these model runs, the IRI-2007 model, and geomagnetic middle-latitude ionosonde data (NmF2) from the World Data Center to determine how well the models simulated the event and to understand the causes of model-data disagreement. The following conclusions were drawn from this study: (1) skill scores were more often negative than positive on average; (2) the best and the worst skill scores occurred on the recovery day; (3) the line plots comparing models to data look better than the skill scores might suggest; (4) skill scores are significantly affected by timing issues and large, short-duration variability; (5) skill scores give an indication of the relative ability of one model relative to another, rather than an absolute statement of model accuracy; (6) the models capture negative storm effects better than they capture positive storm effects; (7) the TING model captured many short duration features seen in the data at high middle latitude stations that result from changes in the size of the auroral oval; (8) CMIT overestimates the energy driving changes in NmF2, whereas TING provides approximately the correct energy input as a result of the saturation effects on potential that are included in TING; and (9) both TING and CMIT electron densities decreased too rapidly after sunset