1,805 research outputs found
Excited hadrons on the lattice: Mesons
We present results for masses of excited mesons from quenched calculations
using chirally improved quarks at pion masses down to 350 MeV. The key features
of our analysis are the use of a matrix of correlators from various source and
sink operators and a basis which includes quark sources with different spatial
widths, thereby improving overlap with states exhibiting radial excitations.Comment: 8 pages, 8 figures; version accepted to PR
Equation of State and Heavy-Quark Free Energy at Finite Temperature and Density in Two Flavor Lattice QCD with Wilson Quark Action
We study the equation of state at finite temperature and density in
two-flavor QCD with the RG-improved gluon action and the clover-improved Wilson
quark action on a lattice. Along the lines of constant physics
at and 0.80, we compute the second and forth
derivatives of the grand canonical partition function with respect to the quark
chemical potential and the isospin chemical potential
at vanishing chemical potentials, and study the
behaviors of thermodynamic quantities at finite using these derivatives
for the case . In particular, we study density fluctuations at
none-zero temperature and density by calculating the quark number and isospin
susceptibilities and their derivatives with respect to . To suppress
statistical fluctuations, we also examine new techniques applicable at low
densities. We find a large enhancement in the fluctuation of quark number when
the density increased near the pseudo-critical temperature, suggesting a
critical point at finite terminating the first order transition line
between hadronic and quark gluon plasma phases. This result agrees with the
previous results using staggered-type quark actions qualitatively. Furthermore,
we study heavy-quark free energies and Debye screening masses at finite density
by measuring the first and second derivatives of these quantities for various
color channels of heavy quark-quark and quark-anti-quark pairs. The results
suggest that, to the leading order of , the interaction between two
quarks becomes stronger at finite densities, while that between quark and
anti-quark becomes weaker.Comment: 38 pages, 63 figure
A Novel Enediynyl Peptide Inhibitor of Furin That Blocks Processing of proPDGF-A, B and proVEGF-C
BACKGROUND: Furin represents a crucial member of secretory mammalian subtilase, the Proprotein Convertase (PC) or Proprotein Convertase Subtilisin/Kexin (PCSK) superfamily. It has been linked to cancer, tumorgenesis, viral and bacterial pathogenesis. As a result it is considered a major target for intervention of these diseases. METHODOLOGY/PRINCIPAL FINDINGS: Herein, we report, for the first time, the synthesis and biological evaluation of a newly designed potent furin inhibitor that contains a highly reactive beta-turn inducing and radical generating "enediynyl amino acid" (Eda) moiety. "Eda" was inserted between P1 and P1' residues of hfurin(98-112) peptide, derived from the primary cleavage site of furin's own prodomain. The resulting hexadecapeptide derivative inhibited furin in vitro with IC(50) approximately 40 nM when measured against the fluorogenic substrate Boc-RVRR-MCA. It also inhibited furin-mediated cleavage of a fluorogenic peptide derived from hSARS-CoV spike protein with IC(50) approximately 193 nM. Additionally it also blocked furin-processing of growth factors proPDGF-A, B and VEGF-C that are linked to tumor genesis and cancer. Circular dichroism study showed that this inhibitor displayed a predominantly beta-turn structure while western blots confirmed its ability to protect furin protein from self degradation. CONCLUSION/SIGNIFICANCE: These findings imply its potential as a therapeutic agent for intervention of cancer and other furin-associated diseases
Chiral Gauge Theory on Lattice with Domain Wall Fermions
We investigate a U(1) lattice chiral gauge theory with domain wall fermions
and compact gauge fixing. In the reduced model limit, our perturbative and
numerical investigations show that there exist no extra mirror chiral modes.
The longitudinal gauge degrees of freedom have no effect on the free domain
wall fermion spectrum consisting of opposite chiral modes at the domain wall
and at the anti-domain wall which have an exponentially damped overlap.Comment: 16 pages revtex, 5 postscript figures, PRD versio
Burst dynamics during drainage displacements in porous media: Simulations and experiments
We investigate the burst dynamics during drainage going from low to high
injection rate at various fluid viscosities. The bursts are identified as
pressure drops in the pressure signal across the system. We find that the
statistical distribution of pressure drops scales according to other systems
exhibiting self-organized criticality. The pressure signal was calculated by a
network model that properly simulates drainage displacements. We compare our
results with corresponding experiments.Comment: 7 pages, 4 figures. Submitted to Europhys. Let
Biometric relationships of the black-lip pearl oyster Pinctada margaritifera (Linnaeus, 1758) from the Andaman and Nicobar waters
The black-lip pearl oyster, Pinctada margaritifera is widely distributed in Indo-Pacific region
and has prime importance in the production of black pearls. In India, its natural occurrence is
confined to the Andaman and Nicobar Islands. The biometric relationships between (dorso-ventral
measurement [DVM] and Hinge Length [HL]; Thickness [THK] and Total Weight [TWT]) were
studied from 458 oysters collected from these islands which were grouped in to 5 length classes.
In all size groups, there was increase in weight with increase in length. The highest coefficient
(r2=0.7828) was obtained for the animals with DVM ranging from 76 to 95 mm. The correlation
coefficient ‘r’ was low for DVM-HL and slightly higher for DVM-THK. Comparisons of biometric
relationships of the natural populations of the Indian pearl oysters with that of farmed oysters in
other regions indicated xenomorphism in pearl oysters in Andaman and Nicobar Islands due to
restricted space in natural habitats
On mixed convection in a cavity with sinusoidally heated moving lid and uniformly heated and cooled side walls
Missense mutation in the ATPase, aminophospholipid transporter protein ATP8A2 is associated with cerebellar atrophy and quadrupedal locomotion
Cataloged from PDF version of article.Cerebellar ataxia, mental retardation and dysequilibrium syndrome is a rare and heterogeneous condition. We investigated a consanguineous family from Turkey with four affected individuals exhibiting the condition. Homozygosity mapping revealed that several shared homozygous regions, including chromosome 13q12. Targeted next-generation sequencing of an affected individual followed by segregation analysis, population screening and prediction approaches revealed a novel missense variant, p.I376M, in ATP8A2. The mutation lies in a highly conserved C-terminal transmembrane region of E1 E2 ATPase domain. The ATP8A2 gene is mainly expressed in brain and development, in particular cerebellum. Interestingly, an unrelated individual has been identified, in whom mental retardation and severe hypotonia is associated with a de novo t(10;13) balanced translocation resulting with the disruption of ATP8A2. These findings suggest that ATP8A2 is involved in the development of the cerebro-cerebellar structures required for posture and gait in humans. © 2013 Macmillan Publishers Limited All rights reserved
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