The interaction between rs 3,807,992 genotypes with the dietary inflammatory index on Leptin, Leptin resistance, and Galectin 3 in obese and overweight women

OBJECTIVE: Obesity is related to increasing leptin and some inflammatory factors that are associated with low-grade inflammation. Moreover, several studies have shown Caveolin-1 (CAV1) genetic variations may be associated with dietary intake. The current study aimed to evaluate the interaction of CAV1 rs3807992 with types of the energy-adjusted dietary inflammatory index (EDII) in leptin, leptin resistance, and Galectin 3, as inflammatory factors. METHODS: This cross-sectional study was carried out on 363 overweight and obese females. Dietary intake and DII were obtained from a 147-item food frequency questionnaire (FFQ). The CAV-1 genotype was measured using the PCR-RFLP method. Anthropometric values and serum levels of leptin and Galectin 3 were measured by standard methods. RESULTS: Increased adherence to EDII in the interaction with CAV1 genotypes led to an increase in leptin level 79.15 (mg/l) (β = 79.15, CI = − 1.23,163.94, P = 0.04) in model 3, after controlling for further potential confounders. By contrast, adherence to EDII in the interaction with the genotype including risk alleles showed no significant interaction, even after adjustment in model 3 (β = 0.55, CI = − 0.99, 2.09, P = 0.48). Although, a marginal positive significant interaction was found between EDII and CAV1 genotypes on Galectin 3, after adjustment in model 3 (β = 31.35, CI = 0.13, 77.13, P = 0.05). CONCLUSIONS: The present study indicates that a high adherence of EDII and CAV1 genotypes containing risk alleles may be a prognostic factor and increase both leptin and Galectin3. However, it seems that the presence of interaction was not on leptin resistance. Further functional studies are necessary to elucidate the exact mechanism

The association of Carbohydrate Quality Index with cardiovascular disease risk factors among women with overweight and obesity:A cross-sectional study

Purpose: Diet is one of the most important factors influencing cardiovascular disease (CVD). The negative relationship between carbohydrate intake with lipid profiles and body weight has been previously investigated. However, this is the first study seeking to assess the association of carbohydrate quality index (CQI) with CVD risk factors. Methods: This cross-sectional study was conducted on 291 Iranian overweight and obese women, with a body mass index (BMI) ranging between 25 and 40 kg/m2, and aged 18–48 years. CQI scores were calculated by using a validated 168-item semi-quantitative food frequency questionnaire (FFQ). Biochemical and anthropometric measures were assessed using standard methods, and bioelectrical impedance was used to measure body composition. Results: We observed that fruits (P < 0.001), vegetables (P < 0.001), and protein (P = 0.002) intake were higher in participants with a higher score of the CQI. When we adjusted for potential confounders, we observed that the CQI was negatively related to systolic blood pressure (SBP) (β = −6.10; 95% CI = −10.11, −2.10; P = 0.003) and DBP (β = −3.11; 95% CI = −6.15, −0.08; P = 0.04). Also, greater adherence to a high CQI dietary pattern, compared to the reference group, was negatively related to HOMA-IR (β = −0.53; 95% CI = −0.94, −0.12) (P for trend = 0.01), WC (β = −3.18; 95% CI = −6.26, −0.10) (P for trend = 0.04), BMI (β = −1.21; 95% CI = −2.50, 0.07) (P for trend = 0.06), and BF (β = −2.06; 95% CI = −3.82, −0.30) (P for trend = 0.02). Conclusion: In line with previous studies, the CQI was inversely associated with blood pressure, WC, BMI, and BF. Further prospective and clinical trial studies are suggested to confirm these data

Investigating the Impact of Collagen-Chitosan Derived from Scomberomorus Guttatus and Shrimp Skin on Second-Degree Burn in Rats Model

Background: The present study focused on burning as one of the main causes of mortality with detrimental economic and social effects in the world. The purpose of this study was to investigate the impact of collagen-chitosan gel extracted from Scomberomorus guttatus and shrimp skin in the treatment of second degree burn healing among rats. Materials & method: To fulfill the purpose of the study, chitosan and collagen were extracted respectively from shrimp and Scomberomorus guttatus skin waste by the acid-based method and were evaluated by using Pico Tag, SDS-PAGE. The burn wound healing efficiency of marine collagen-chitosan gel was examined in vivo using rats. Three different ratios of collagen and chitosan blend (Col-CH, 1:3, 1:1 and 3:1) were prepared to obtain the most effective Col-CH gel for burn wound healing and were compared to the animals treated with silver sulfadiazine ointment. Healing burn wound was studied by measuring wound surface area with Image J and histopathologic examination was carried out based on the mean of epithelialization, fibroblastic cells, acute and chronic inflammatory cells, angiogenesis, structure collagen and the amount of collagen on days 15 and 25 post-burn. Results: The results of SDS-PAGE indicated that the extracted collagen was type I and it was composed of two α (α1 and α2) chains. Amino acid analysis showed a much higher glaycin content in extracted collagen which amounted to one-third of the total amino. The wound surface measurement showed a significant reduction in wound size in the group treated with Col-CH (3:1) compared to silver-sulfadiazine treated group on 15th and 25th days. Histopathological findings represented a high score in epithelialization, collagen, collagen structure, fibroblast cell and a decrease in inflammatory cells infiltration in Col-CH (3:1) treated group on 25th day. The most obvious finding of the present study is that chitosan-collagen gel (3:1) represented a better efficacy compared to sulfadiazine in burn wound healing on day 25 post-burn. © 2021 The Japanese Society for Regenerative Medicin

Investigation of Water Holding Capacity of Sugarcane Mulch for Sand Dune Stabilization in Ahvaz

Introduction: Wind erosion is one of the most serious problems in southwest Iran. Fine-grained structure of sand dunes with not enough strong composition and their low moisture retention property make them susceptible to wind erosion. They lack organic matter and are considered inherently of low fertility (Ahmadi, 2002). Studies have shown that non-erodible materials which include bentonite clay (Diouf et al., 1990), ureamelamine formaldehyde and urea–formaldehyde with 0.25% sodium chloride (Lahalih and Ahmed, 1998), acids, enzymes, lignosulfonates, polymers, tree resins (Santoni et al., 2001), waterborne polymer emulsion (Al-Khanbashi and Abdalla, 2006), polyvinyl alcohol and a polyvinyl acetate emulsion (Newman et al., 2005; Han et al., 2007), ash and polyacrylamide (Yang and Zejun, 2012).have significant potential in reducing wind erosion The area under farming of sugarcane in Khuzestan, Iran, is more than 130,000, ha. Vinasse and Filter Kike are two organic ingredients of sugarcane residues which are generated as byproduct materials insugarcane processing. In recent years these residues have been released into the environment and cause it regarded as water pollutant. Over 800,000 m3 of Vinasse is annually stored in each agro-industry. Vinasse also is rich in K, Ca, and Mg with moderate amounts of P and N,and non toxic complexes or heavy metals. Filter Kike is another residue produced in huge amounts by the agro-industry that is composed of cellulosic substances, CaCO3, N, P, K, organic matter, and clay. Therefore, the objective of this research is to investigate the effect of sugarcane mulch on water holding capacity in soil. This study is performed to evaluate the feasibility of using sugarcane residues inproduce of ecofriendly mulches for environmental use. In order of achieving these goals, Vinase, Filter Cake, and clay soil from near the sand dunes were used as sugarcane mulches. Further comparison between traditional oil mulches and sugarcane mulches was also carried out. Materials and Methods: The experiments were conducted in the soil laboratory of Khuzestan-Ramin University of Agricultural and Natural Resources. For this purpose, Vinasse and clay soil samples were used to make sugarcane mulches. Different quantities of Vinase, Filter Kike, and clay samples were mixed in water to select the best batch mix (by trial and error). A mulch sprayer was then used to spray the batch mixes on sand dune beds packed in trays 1054510cm. In addition, the same procedures were employed to choose an oil mulch treatment as control for comparison with sugarcane mulch treatments. Water holding capacity was measured in 100, 333, 1000, 5000, 10000, 15000 hPa suction by pressure plate and Macro elements ( N, P, K ) and microelements (Fe, Cu, Zn) were determined by conventional methods and atomic absorption in each treatment. Experiments were carried out using a factorial experiment with a completely random design in threereplicants. Results and Discussion: The wide range of pH values obtained were dependent on the different batch mixes of Vinase, clay soil, and Filter Kike. Reaction (pH) of Vinase was lower (5.00) than those of Filter Kike (7.5) and soil (8.07). EC and SAR values of treatments were both affected by Vinase, soil, and Filter Kike. This could be due to the higher EC and the low level of SAR in Vinase in contrast to soil and Filter Kike. EC and SAR are two major chemical factors known to affect sand dune stabilization (Bresler, 1982). Based on Table 3, N, P, K, Fe, Zn, and Cu in sugarcane mulches varied from 0.15-0.66 (%), 10.82-28.46 (mg.Kg-1), 133.01-633.33 (meq.Li-1), 15.22-36.76 (mg.Kg-1), 2.19-2.93 (mg.Kg-1), and 0.92-4.1 (mg.Kg-1), respectively. The results revealed that sugarcane mulches are rich in N, P, and K that are essential in soil fertility. The results determined that there was significant effect (

The relationship between dietary phytochemical index and resting metabolic rate mediated by inflammatory factors in overweight and obese women:a cross-sectional study

BACKGROUND: Unhealthy dietary patterns are the most important modifiable risk factors for obesity and overweight. This study aimed to examine the relationship between Dietary Phytochemical Index (DPI) and resting metabolic rate (RMR), mediated by inflammatory factors, in overweight and obese women. METHODS: A total of 404 women, aged 18–48 years, were included in the cross-sectional study. DPI was calculated using the 147-item food frequency questionnaire (FFQ). Anthropometric measurements, RMR, and blood biomarkers were assessed using standard protocols. RESULTS: There was marginally significant association between adherence to DPI and RMR status in the crude model (OR = 1.41, 95% CI 0.94–2.11, P = 0.09). After adjusting for potential confounders, a significant association was seen between the DPI and increase RMR.per.kg (OR = 2.77, 95% CI 0.98–7.82, P = 0.05). Our results indicated that plasminogen activator inhibitor-1 (PAI-1), transforming growth factor (TGF-β), and monocyte chemoattractant protein-1 (MCP-1) had a mediatory effect on the association between RMR and DPI (P > 0.05). Indeed, it was shown that, PAI-1, TGF-β, and MCP-1 destroyed the significance of this association and could be considered as mediating markers. However, no mediating effect was observed for high-sensitivity C reactive protein (hs-CRP). CONCLUSIONS: Adherence to DPI can improve the RMR by reducing levels of inflammatory markers, and may be considered as a treatment for obesity. However, more long-term studies are recommended

Bilan hydrique et isotopique d'un sol soumis a l'evaporation: cas d'un milieu controle

International audienc

The association between gut microbiota and resting metabolic rate in overweight/obese women:a case-control study

Purpose: When examining the underlying processes of obesity, evaluation of gut flora and energy homeostasis can be crucial since disruption of the normal gut microbiota community and energy imbalances are significant factors in the development of obesity. Therefore, this study aimed to compare the relative abundance of important obesity modulator gut microbiota (including Firmicutes, Bacteroidetes, Bifidobactrium spp., Lactobacillus spp., Bacteroides fragilis, Faecalibacterium prausnitzii, Akkermansia muciniphila, and Escherichia coli) in fecal samples of normometabilic and hypometabolic overweight/obese individuals. Methods: This matched case–control study conducted on 36 healthy women aged 18–50 years old. An indirect calorimeter and impedance body analyzer were used to assess resting metabolic rate (RMR) and body composition, respectively. Dietary intake and physical activity were assessed using questionnaires. To determine the abundance of the abovementioned gut microbiota, quantitative polymerase chain reaction (qPCR) method was performed. Moreover, ELISA kits were used to assess leptin, ghrelin, and insulin hormones. Results: The results highlighted higher load of Firmicutes (p = 0.02), F. prausnitzii (p &lt; 0.001), and B. fragilis (p = 0.02) in the normometabolic individuals compared to the hypometabolic ones. Besides, the positive correlation between the abundance of Firmicutes (β = 7.76 × 10 –1, p = 0.01), F. prausnitzii (β = 1.29 × 10 –5, p = 0.01), and B. fragilis (β = 4.13 × 10 –6, p = 0.04) with the RMR have been shown. Whereas the abundance of Bacteroidetes, A. muciniphila, Lactobacillus spp., Bifidobactrium spp., and E. coli showed no significant difference (p &gt; 0.05) and no significant correlation with the RMR except Lactobacillus spp. (β = 1.73 × 10 –4, p = 0.01). Conclusion: It seems that gut microbiota can be a potential target for refining host energy homeostasis and treating obesity and its consequences.</p

Obstructive Sleep Apnoea and Retinopathy in Patients with Type 2 Diabetes: A Longitudinal Study.

AIMS To assess the relationship between obstructive sleep apnoea (OSA) and diabetic retinopathy (DR) in patients with type 2 diabetes (T2D) and to assess whether OSA is associated with its progression). METHODS A longitudinal study from diabetes clinics in two UK hospitals was conducted. Patients known to have any respiratory disorder (including OSA) were excluded. DR was assessed using 2x45degrees retinal images per eye. OSA was assessed using a home-based, multi-channel cardiorespiratory device. RESULTS 230 patients were included. Sight threatening DR (STDR) and OSA prevalence was 36.1% and 63.9% respectively. STDR prevalence was higher in patients with OSA (OSA+) vs. those without (OSA-) (42.9% vs. 24.1% (p0.004). After adjustment for confounders, OSA remained independently associated with STDR (OR 2.3, 95%CI 1.1-4.9, p=0.04). After a median (IQR) follow-up of 43.0 (37.0-51.0) months, OSA+ patients were more likely to develop pre-/proliferative DR compared to OSA- patients (18.4% vs. 6.1%, p=0.02). After adjustment for confounders, OSA remained an independent predictor of progression to pre-/proliferative DR (OR 5.2, 95%CI 1.2-23.0, p=0.03). Patients who received continuous positive airway pressure (CPAP) treatment were significantly less likely to develop pre-/proliferative DR. CONCLUSIONS OSA is associated with STDR in patients with T2D. OSA is an independent predictor for the progression to pre-/proliferative DR. CPAP treatment was associated with reduction in pre-/proliferative DR. Interventional studies are needed to assess the impact of OSA treatment on STDR