248 research outputs found
Paradigm shift in hydrocephalus research in legacy of Dandy’s pioneering work: rationale for third ventriculostomy in communicating hydrocephalus
OBJECTIVE: This study aims to question the generally accepted cerebrospinal fluid (CSF) bulk flow theory suggesting that the CSF is exclusively absorbed by the arachnoid villi and that the cause of hydrocephalus is a CSF absorption deficit. In addition, this study aims to briefly describe the new hydrodynamic concept of hydrocephalus and the rationale for endoscopic third ventriculostomy (ETV) in communicating hydrocephalus. CRITIQUE: The bulk flow theory has proven incapable of explaining the pivotal mechanisms behind communicating hydrocephalus. Thus, the theory is unable to explain why the ventricles enlarge, why the CSF pressure remains normal and why some patients improve after ETV. HYDRODYNAMIC CONCEPT OF HYDROCEPHALUS: Communicating hydrocephalus is caused by decreased intracranial compliance increasing the systolic pressure transmission into the brain parenchyma. The increased systolic pressure in the brain distends the brain towards the skull and simultaneously compresses the periventricular region of the brain against the ventricles. The final result is the predominant enlargement of the ventricles and narrowing of the subarachnoid space. The ETV reduces the increased systolic pressure in the brain simply by venting ventricular CSF through the stoma. The patent aqueduct in communicating hydrocephalus is too narrow to vent the CSF sufficiently
Tensor hierarchies, Borcherds algebras and E11
Gauge deformations of maximal supergravity in D=11-n dimensions generically
give rise to a tensor hierarchy of p-form fields that transform in specific
representations of the global symmetry group E(n). We derive the formulas
defining the hierarchy from a Borcherds superalgebra corresponding to E(n).
This explains why the E(n) representations in the tensor hierarchies also
appear in the level decomposition of the Borcherds superalgebra. We show that
the indefinite Kac-Moody algebra E(11) can be used equivalently to determine
these representations, up to p=D, and for arbitrarily large p if E(11) is
replaced by E(r) with sufficiently large rank r.Comment: 22 pages. v2: Published version (except for a few minor typos
detected after the proofreading, which are now corrected
The general gaugings of maximal d=9 supergravity
We use the embedding tensor method to construct the most general maximal
gauged/massive supergravity in d=9 dimensions and to determine its extended
field content. Only the 8 independent deformation parameters (embedding tensor
components, mass parameters etc.) identified by Bergshoeff \textit{et al.} (an
SL(2,R) triplet, two doublets and a singlet can be consistently introduced in
the theory, but their simultaneous use is subject to a number of quadratic
constraints. These constraints have to be kept and enforced because they cannot
be used to solve some deformation parameters in terms of the rest. The
deformation parameters are associated to the possible 8-forms of the theory,
and the constraints are associated to the 9-forms, all of them transforming in
the conjugate representations. We also give the field strengths and the gauge
and supersymmetry transformations for the electric fields in the most general
case. We compare these results with the predictions of the E11 approach,
finding that the latter predicts one additional doublet of 9-forms, analogously
to what happens in N=2, d=4,5,6 theories.Comment: Latex file, 43 pages, reference adde
Familial Adhesive Arachnoiditis Associated with Syringomyelia
Adhesive arachnoiditis is a rare condition, often complicated by syringomyelia. This pathologic entity is usually associated with prior spinal surgery, spinal inflammation or infection, and hemorrhage. The usual symptoms of arachnoiditis are pain, paresthesia, and weakness of the low extremities due to the nerve entrapment. A few cases have had no obvious etiology. Previous studies have reported one family with multiple cases of adhesive arachnoiditis. We report a second family of Belgian origin with multiple cases of arachnoiditis and secondary syringomyelia in the affected individuals
Superconformal symmetry and maximal supergravity in various dimensions
In this paper we explore the relation between conformal superalgebras with 64
supercharges and maximal supergravity theories in three, four and six
dimensions using twistorial oscillator techniques. The massless fields of N=8
supergravity in four dimensions were shown to fit into a CPT-self-conjugate
doubleton supermultiplet of the conformal superalgebra SU(2,2|8) a long time
ago. We show that the fields of maximal supergravity in three dimensions can
similarly be fitted into the super singleton multiplet of the conformal
superalgebra OSp(16|4,R), which is related to the doubleton supermultiplet of
SU(2,2|8) by dimensional reduction. Moreover, we construct the ultra-short
supermultiplet of the six-dimensional conformal superalgebra OSp(8*|8) and show
that its component fields can be organized in an on-shell superfield. The
ultra-short OSp(8*|8) multiplet reduces to the doubleton supermultiplet of
SU(2,2|8) upon dimensional reduction. We discuss the possibility of a chiral
maximal (4,0) six-dimensional supergravity theory with USp(8) R-symmetry that
reduces to maximal supergravity in four dimensions and is different from
six-dimensional (2,2) maximal supergravity, whose fields cannot be fitted into
a unitary supermultiplet of a simple conformal superalgebra. Such an
interacting theory would be the gravitational analog of the (2,0) theory.Comment: 54 pages, PDFLaTeX, Section 5 and several references added. Version
accepted for publication in JHE
ICP curve morphology and intracranial flow-volume changes: a simultaneous ICP and cine phase contrast MRI study in humans
Background: The intracranial pressure (ICP) curve with its different peaks has been extensively studied, but the exact physiological mechanisms behind its morphology are still not fully understood. Both intracranial volume change (ΔICV) and transmission of the arterial blood pressure have been proposed to shape the ICP curve. This study tested the hypothesis that the ICP curve correlates to intracranial volume changes. Methods: Cine phase contrast magnetic resonance imaging (MRI) examinations were performed in neuro-intensive care patients with simultaneous ICP monitoring. The MRI was set to examine cerebral arterial inflow and venous cerebral outflow as well as flow of cerebrospinal fluid over the foramen magnum. The difference in total flow into and out from the cranial cavity (Flowtot) over time provides the ΔICV. The ICP curve was compared to the Flowtot and the ΔICV. Correlations were calculated through linear and logarithmic regression. Student’s t test was used to test the null hypothesis between paired samples. Results: Excluding the initial ICP wave, P1, the mean R2 for the correlation between the ΔICV and the ICP was 0.75 for the exponential expression, which had a higher correlation than the linear (p = 0.005). The first ICP peaks correlated to the initial peaks of Flowtot with a mean R2 = 0.88. Conclusion: The first part, or the P1, of the ICP curve seems to be created by the first rapid net inflow seen in Flowtot while the rest of the ICP curve seem to correlate to the ΔICV
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