1,850 research outputs found
An investigation into the feasibility of myoglobin-based single-electron transistors
Myoglobin single-electron transistors were investigated using nanometer- gap
platinum electrodes fabricated by electromigration at cryogenic temperatures.
Apomyoglobin (myoglobin without heme group) was used as a reference. The
results suggest single electron transport is mediated by resonant tunneling
with the electronic and vibrational levels of the heme group in a single
protein. They also represent a proof-of-principle that proteins with redox
centers across nanometer-gap electrodes can be utilized to fabricate
single-electron transistors. The protein orientation and conformation may
significantly affect the conductance of these devices. Future improvements in
device reproducibility and yield will require control of these factors
First Scientific Results From The Infrared Astronomical Satellite (IRAS)
The Infrared Astronomical Satellite (IRAS) was successfully launched on 25 January 1983 and terminated science data acquisition on 22 November 1983. The in-orbit performance of the telescope has been described in two previous papers in these proceedings. A previous description of very preliminary scientific results from the mission has been given in these proceedings, while far more extensive reports have been given elsewhere. In this paper we will summarize some of the results obtained to date from the IRAS data. The work to date has sampled only a small fraction of the IRAS data; the study of the data from the IRAS survey will continue for many years to come
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Fabrication of an Active Electronic Device Using a Hetero-bimetallic Coordination Polymer
A nickel(II)/lead(II) coordination polymer [(NCS)Pb(H2O)LNi(NCS)]n {H2L=N,NâČ-bis(3-methoxysalicylidene)propane-1,3-diamine} has been synthesized and characterized. The band gap (3.18 eV) calculated from Taucâs plot suggests the semiconducting nature of the complex. The material has a photosensitivity of 5.76, indicating its applicability in the fabrication of photosensitive devices. The complex has been successfully applied in a technologically challenging thin-ïŹlm photosensitive Schottky device
A kapwa-infused paradigm in teaching Catholic theology/catechesis in a multireligious classroom in the Philippines
The increasing religious diversity in educational space has raised a legitimate question on how Catholic theology/ catechesis must be taught in Philippine Catholic universities given the institutional mandate to educate students âinto the faith of the Church through teaching of Christian doctrine in an organic and systematic wayâ (Wuerl, 2013, 1). On this note, the paper makes reference to âcentered plural- ismâ (CP), a positional posture espoused by Georgetown University in dealing with this predicament. In an attempt to (re) appropriate CP into local context, there is a need to explore the Filipino conception of self/others as enveloped within the indigenous concept of kapwa. Hereon, the paper finds that CP is not just feasibly suitable in local context but with kapwa's more inclusive description of the relationship of self and others, a CPâbased teaching paradigm in theology/ catechesis is a promising project in the educational scene of the Philippines
Mathematical description of bacterial traveling pulses
The Keller-Segel system has been widely proposed as a model for bacterial
waves driven by chemotactic processes. Current experiments on {\em E. coli}
have shown precise structure of traveling pulses. We present here an
alternative mathematical description of traveling pulses at a macroscopic
scale. This modeling task is complemented with numerical simulations in
accordance with the experimental observations. Our model is derived from an
accurate kinetic description of the mesoscopic run-and-tumble process performed
by bacteria. This model can account for recent experimental observations with
{\em E. coli}. Qualitative agreements include the asymmetry of the pulse and
transition in the collective behaviour (clustered motion versus dispersion). In
addition we can capture quantitatively the main characteristics of the pulse
such as the speed and the relative size of tails. This work opens several
experimental and theoretical perspectives. Coefficients at the macroscopic
level are derived from considerations at the cellular scale. For instance the
stiffness of the signal integration process turns out to have a strong effect
on collective motion. Furthermore the bottom-up scaling allows to perform
preliminary mathematical analysis and write efficient numerical schemes. This
model is intended as a predictive tool for the investigation of bacterial
collective motion
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Overview of mathematical approaches used to model bacterial chemotaxis I: the single cell
Mathematical modeling of bacterial chemotaxis systems has been influential and insightful in helping to understand experimental observations. We provide here a comprehensive overview of the range of mathematical approaches used for modeling, within a single bacterium, chemotactic processes caused by changes to external gradients in its environment. Specific areas of the bacterial system which have been studied and modeled are discussed in detail, including the modeling of adaptation in response to attractant gradients, the intracellular phosphorylation cascade, membrane receptor clustering, and spatial modeling of intracellular protein signal transduction. The importance of producing robust models that address adaptation, gain, and sensitivity are also discussed. This review highlights that while mathematical modeling has aided in understanding bacterial chemotaxis on the individual cell scale and guiding experimental design, no single model succeeds in robustly describing all of the basic elements of the cell. We conclude by discussing the importance of this and the future of modeling in this area
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