Excited nucleon electromagnetic form factors from broken spin-flavor symmetry

A group theoretical derivation of a relation between the N --> Delta charge quadrupole transition and neutron charge form factors is presented.Comment: 4 pages, Proc. of the 12 th Int'l. Workshop on the Physics of Excited Nucleons, NSTAR 2009, Beijing, April 19-22, 200

Impact of nuclear effects on the determination of the nucleon axial mass

We analize the influence of nuclear effects on the determination of the nucleon axial mass from nuclear cross sections. Our work is based on a formalism widely applied to describe electron-nucleus scattering data in the impulse approximation regime. The results of numerical calculations show that correlation effects, not taken into account by the relativistic Fermi gas model, sizably affect the $Q^2$-dependence of the cross section. However, their inclusion does not appear to explain the large values of the axial mass recently reported by the K2K and MiniBooNE collaborations.Comment: 4 pages, three figure

Pole Term and Gauge Invariance in Deep Inelastic Scattering

In this paper we reconcile two contradictory statements about deep inelastic scattering (DIS) in manifestly covariant theories: (i) the scattering must be gauge invariant, even in the deep inelastic limit, and (ii) the pole term (which is not gauge invariant in a covariant theory) dominates the scattering amplitude in the deep inelastic limit. An ``intermediate'' answer is found to be true. We show that, at all energies, the gauge dependent part of the pole term cancels the gauge dependent part of the rescattering term, so that both the pole and rescattering terms can be separately redefined in a gauge invariant fashion. The resulting, redefined pole term is then shown to dominate the scattering in the deep inelastic limit. Details are worked out for a simple example in 1+1 dimensions.Comment: 10 figure

Inelastic electron-nucleus scattering and scaling at high inelasticity

Highly inelastic electron scattering is analyzed within the context of the unified relativistic approach previously considered in the case of quasielastic kinematics. Inelastic relativistic Fermi gas modeling that includes the complete inelastic spectrum - resonant, non-resonant and Deep Inelastic Scattering - is elaborated and compared with experimental data. A phenomenological extension of the model based on direct fits to data is also introduced. Within both models, cross sections and response functions are evaluated and binding energy effects are analyzed. Finally, an investigation of the second-kind scaling behavior is also presented.Comment: 39 pages, 13 figures; formalism extended and slightly reorganized, conclusions extended; to appear in Phys. Rev.

Scaling in many-body systems and proton structure function

The observation of scaling in processes in which a weakly interacting probe delivers large momentum ${\bf q}$ to a many-body system simply reflects the dominance of incoherent scattering off target constituents. While a suitably defined scaling function may provide rich information on the internal dynamics of the target, in general its extraction from the measured cross section requires careful consideration of the nature of the interaction driving the scattering process. The analysis of deep inelastic electron-proton scattering in the target rest frame within standard many-body theory naturally leads to the emergence of a scaling function that, unlike the commonly used structure functions $F_1$ and $F_2$, can be directly identified with the intrinsic proton response.Comment: 11 pages, 4 figures. Proceedings of the 11th Conference on Recent Progress in Many-Body Theories, Manchester, UK, July 9-13 200

Inclusive versus Exclusive EM Processes in Relativistic Nuclear Systems

Connections are explored between exclusive and inclusive electron scattering within the framework of the relativistic plane-wave impulse approximation, beginning with an analysis of the model-independent kinematical constraints to be found in the missing energy--missing momentum plane. From the interplay between these constraints and the spectral function basic features of the exclusive and inclusive nuclear responses are seen to arise. In particular, the responses of the relativistic Fermi gas and of a specific hybrid model with confined nucleons in the initial state are compared in this work. As expected, the exclusive responses are significantly different in the two models, whereas the inclusive ones are rather similar. By extending previous work on the relativistic Fermi gas, a reduced response is introduced for the hybrid model such that it fulfills the Coulomb and the higher-power energy-weighted sum rules. While incorporating specific classes of off-shellness for the struck nucleons, it is found that the reducing factor required is largely model-independent and, as such, yields a reduced response that is useful for extracting the Coulomb sum rule from experimental data. Finally, guided by the difference between the energy-weighted sum rules of the two models, a version of the relativistic Fermi gas is devised which has the 0$^{\rm th}$, 1$^{\rm st}$ and 2$^{\rm nd}$ moments of the charge response which agree rather well with those of the hybrid model: this version thus incorporates {\em a priori} the binding and confinement effects of the stuck nucleons while retaining the simplicity of the original Fermi gas.Comment: LaTex file with 15 .ps figure

Inelastic nucleon contributions in (e,e′)(e,e^\prime) nuclear response functions

We estimate the contribution of inelastic nucleon excitations to the $(e,e^\prime)$ inclusive cross section in the CEBAF kinematic range. Calculations are based upon parameterizations of the nucleon structure functions measured at SLAC. Nuclear binding effects are included in a vector-scalar field theory, and are assumed have a minimal effect on the nucleon excitation spectrum. We find that for q\lsim 1 GeV the elastic and inelastic nucleon contributions to the nuclear response functions are comparable, and can be separated, but with roughly a factor of two uncertainty in the latter from the extrapolation from data. In contrast, for q\rsim 2 GeV this uncertainty is greatly reduced but the elastic nucleon contribution is heavily dominated by the inelastic nucleon background.Comment: 20 pages, 7 figures available from the authors at Department of Physics and Astronomy, University of Rochester, Rochester NY 1462

The Oncogenic Lung Cancer Fusion Kinase CD74-ROS Activates a Novel Invasiveness Pathway through E-Syt1 Phosphorylation

Patients with lung cancer often present with metastatic disease and therefore have a very poor prognosis. The recent discovery of several novel ROS receptor tyrosine kinase molecular alterations in non–small cell lung cancer (NSCLC) presents a therapeutic opportunity for the development of new targeted treatment strategies. Here, we report that the NSCLC-derived fusion CD74-ROS, which accounts for 30% of all ROS fusion kinases in NSCLC, is an active and oncogenic tyrosine kinase. We found that CD74-ROS–expressing cells were highly invasive in vitro and metastatic in vivo. Pharmacologic inhibition of CD74-ROS kinase activity reversed its transforming capacity by attenuating downstream signaling networks. Using quantitative phosphoproteomics, we uncovered a mechanism by which CD74-ROS activates a novel pathway driving cell invasion. Expression of CD74-ROS resulted in the phosphorylation of the extended synaptotagmin-like protein E-Syt1. Elimination of E-Syt1 expression drastically reduced invasiveness both in vitro and in vivo without modifying the oncogenic activity of CD74-ROS. Furthermore, expression of CD74-ROS in noninvasive NSCLC cell lines readily conferred invasive properties that paralleled the acquisition of E-Syt1 phosphorylation. Taken together, our findings indicate that E-Syt1 is a mediator of cancer cell invasion and molecularly define ROS fusion kinases as therapeutic targets in the treatment of NSCLC.National Institutes of Health (U.S.) (Grant NCI U01 CA141556

Nuclear Structure based on Correlated Realistic Nucleon-Nucleon Potentials

We present a novel scheme for nuclear structure calculations based on realistic nucleon-nucleon potentials. The essential ingredient is the explicit treatment of the dominant interaction-induced correlations by means of the Unitary Correlation Operator Method (UCOM). Short-range central and tensor correlations are imprinted into simple, uncorrelated many-body states through a state-independent unitary transformation. Applying the unitary transformation to the realistic Hamiltonian leads to a correlated, low-momentum interaction, well suited for all kinds of many-body models, e.g., Hartree-Fock or shell-model. We employ the correlated interaction, supplemented by a phenomenological correction to account for genuine three-body forces, in the framework of variational calculations with antisymmetrised Gaussian trial states (Fermionic Molecular Dynamics). Ground state properties of nuclei up to mass numbers A<~60 are discussed. Binding energies, charge radii, and charge distributions are in good agreement with experimental data. We perform angular momentum projections of the intrinsically deformed variational states to extract rotational spectra.Comment: 32 pages, 15 figure

Relativistic Hamiltonians in many-body theories

We discuss the description of a many-body nuclear system using Hamiltonians that contain the nucleon relativistic kinetic energy and potentials with relativistic corrections. Through the Foldy-Wouthuysen transformation, the field theoretical problem of interacting nucleons and mesons is mapped to an equivalent one in terms of relativistic potentials, which are then expanded at some order in 1/m_N. The formalism is applied to the Hartree problem in nuclear matter, showing how the results of the relativistic mean field theory can be recovered over a wide range of densities.Comment: 14 pages, uses REVTeX and epsfig, 3 postscript figures; a postscript version of the paper is available by anonymous ftp at ftp://carmen.to.infn.it/pub/depace/papers/951