1,004 research outputs found
Mechanisms regulating cAMP-mediated growth of bovine neonatal pulmonary artery smooth muscle cells
Permutations of context-free, ET0L and indexed languages
© 2016 Discrete Mathematics and Theoretical Computer Science (DMTCS), Nancy, France. For a language L, we consider its cyclic closure, and more generally the language Ck(L), which consists of all words obtained by partitioning words from L into k factors and permuting them. We prove that the classes of ET0L and EDT0L languages are closed under the operators Ck. This both sharpens and generalises Brandstädt's result that if L is context-free then Ck(L) is context-sensitive and not context-free in general for k ≥ 3. We also show that the cyclic closure of an indexed language is indexed
Mechanisms regulating cAMP-mediated growth of bovine neonatal pulmonary artery smooth muscle cells
Neonatal pulmonary artery smooth muscle cells (PASMCs) exhibit enhanced
growth capacity and increased growth responses to mitogenic stimuli
compared with adult PASMCs. Because intracellular signals mediating
enhanced growth responses in neonatal PASMCs are incompletely understood,
we questioned whether 1) Gq agonists increase cAMP content and 2)
increased cAMP is proproliferative. Endothelin-1 and angiotensin II
increased both cAMP content and proliferation in neonatal but not in adult
PASMCs. Inhibition of protein kinase C and protein kinase A activity
nearly eliminated the endothelin-1- and angiotensin II-induced growth of
neonatal PASMCs. Moreover, cAMP increased proliferation in neonatal but
not in adult cells. Protein kinase C-stimulated adenylyl cyclase was
expressed in both cell types, suggesting that insensitivity to stimulation
of cAMP in adult cells was not due to decreased enzyme expression. Our
data collectively indicate that protein kinase C stimulation of cAMP is a
critical signal mediating proliferation of neonatal PASMCs that is absent
in adult PASMCs and therefore may contribute to the unique
proproliferative phenotype of these neonatal cells
A gorilla adenovirus-based vaccine against Zika virus induces durable immunity and confers protection in pregnancy
The teratogenic potential of Zika virus (ZIKV) has made the development of an effective vaccine a global health priority. Here, we generate two gorilla adenovirus-based ZIKV vaccines that encode for pre-membrane (prM) and envelope (E) proteins (GAd-Zvp) or prM and the ectodomain of E protein (GAd-Eecto). Both vaccines induce humoral and cell-mediated immune responses and prevent lethality after ZIKV challenge in mice. Protection is antibody dependent, CD
H-ATLAS/GAMA and HeViCS – dusty early-type galaxies in different environments
The Herschel Space Observatory has had a tremendous impact on the study of extragalactic dust. Specifically, early-type galaxies (ETG) have been the focus of several studies. In this paper, we combine results from two Herschel studies – a Virgo cluster study Herschel Virgo Cluster Survey (HeViCS) and a broader, low-redshift Herschel-Astrophysical Terahertz Large Area Survey (H-ATLAS)/Galaxy and Mass Assembly (GAMA) study – and contrast the dust and associated properties for similar mass galaxies. This comparison is motivated by differences in results exhibited between multiple Herschel studies of ETG. A comparison between consistent modified blackbody derived dust mass is carried out, revealing strong differences between the two samples in both dust mass and dust-to-stellar mass ratio. In particular, the HeViCS sample lacks massive ETG with as high a specific dust content as found in H-ATLAS. This is most likely connected with the difference in environment for the two samples. We calculate nearest neighbour environment densities in a consistent way, showing that H-ATLAS ETG occupy sparser regions of the local Universe, whereas HeViCS ETG occupy dense regions. This is also true for ETG that are not Herschel-detected but are in the Virgo and GAMA parent samples. Spectral energy distributions are fit to the panchromatic data. From these, we find that in H-ATLAS the specific star formation rate anticorrelates with stellar mass and reaches values as high as in our Galaxy. On the other hand HeViCS ETG appear to have little star formation. Based on the trends found here, H-ATLAS ETG are thought to have more extended star formation histories and a younger stellar population than HeViCS ETG
Spatial correlation between dust and Hα emission in dwarf irregular galaxies
Using a sample of dwarf irregular galaxies selected from the ALFALFA blind H i-survey and observed using the VIMOS IFU, we investigate the relationship between Hα emission and Balmer optical depth (). We find a positive correlation between Hα luminosity surface density and Balmer optical depth in 8 of 11 at ≥0.8σ significance (6 of 11 at ≥1.0σ) galaxies. Our spaxels have physical scales ranging from 30 to 80 pc, demonstrating that the correlation between these two variables continues to hold down to spatial scales as low as 30 pc. Using the Spearman's rank correlation coefficient to test for correlation between and in all the galaxies combined, we find , indicating a positive correlation at 4σ significance. Our low stellar-mass galaxy results are in agreement with observations of emission line regions in larger spiral galaxies, indicating that this relationship is independent of the size of the galaxy hosting the emission line region. The positive correlation between Hα luminosity and Balmer optical depth within spaxels is consistent with the hypothesis that young star-forming regions are surrounded by dusty birth-clouds
Drivers of Spatial Distributions of Basking Shark (<em>Cetorhinus maximus</em>) in the Southwest Pacific
A new gorilla adenoviral vector with natural lung tropism avoids liver toxicity and is amenable to capsid engineering and vector retargeting
Human adenoviruses have many attractive features for gene therapy applications. However, the high prevalence of preexisting immunity against these viruses in general populations worldwide has greatly limited their clinical utility. In addition, the most commonly used human adenovirus, human adenovirus subgroup C serotype 5 (HAd5), when systemically administered, triggers systemic inflammation and toxicity, with the liver being the most severely affected organ. Here, we evaluated the utility and safety of a new low-seroprevalence gorilla adenovirus (GAd; GC46) as a gene transfer vector in mice. Biodistribution studies revealed that systemically administered GAd had a selective and robust lung endothelial cell (EC) tropism with minimal vector expression throughout many other organs and tissues. Administration of a high dose of GAd accomplished extensive transgene expression in the lung yet elicited no detectable inflammatory histopathology in this organ. Furthermore, GAd, unlike HAd5, did not exhibit hepatotropism or induce liver inflammatory toxicity in mice, demonstrating the exceptional safety profile of the vector vis-à-vis systemic utility. We further demonstrated that the GAd capsid fiber shared the flexibility of the HAd5 equivalent for permitting genetic modification; GAd with the pan-EC-targeting ligand myeloid cell-binding peptide (MBP) incorporated in the capsid displayed a reduced lung tropism and efficiently retargeted gene expression to vascular beds in other organs
Red Galaxy Growth and the Halo Occupation Distribution
We have traced the past 7 Gyr of red galaxy stellar mass growth within dark
matter halos. We have determined the halo occupation distribution, which
describes how galaxies reside within dark matter halos, using the observed
luminosity function and clustering of 40,696 0.2<z<1.0 red galaxies in Bootes.
Half of 10^{11.9} Msun/h halos host a red central galaxy, and this fraction
increases with increasing halo mass. We do not observe any evolution of the
relationship between red galaxy stellar mass and host halo mass, although we
expect both galaxy stellar masses and halo masses to evolve over cosmic time.
We find that the stellar mass contained within the red population has doubled
since z=1, with the stellar mass within red satellite galaxies tripling over
this redshift range. In cluster mass halos most of the stellar mass resides
within satellite galaxies and the intra-cluster light, with a minority of the
stellar mass residing within central galaxies. The stellar masses of the most
luminous red central galaxies are proportional to halo mass to the power of a
third. We thus conclude that halo mergers do not always lead to rapid growth of
central galaxies. While very massive halos often double in mass over the past 7
Gyr, the stellar masses of their central galaxies typically grow by only 30%.Comment: Accepted for publication in the ApJ. 34 pages, 22 Figures, 5 Table
The Grizzly, March 2, 2017
Student Premieres Self-Produced Film on Campus • SPINT Houses to Host Events to Interest Applicants for Next Year • International Perspective: A Japanese Student\u27s Reflection on Exchange Programs • Q&A with Last Year\u27s Faculty Award Winners • Setting the Bar High: Mock Trial Races Toward Success • UC Senior Sprints to the Finish Line • Opinions: The U-Imagine Center Undermines Liberal Education; Entrepreneurship Enhances Liberal Education at UC • Men\u27s Basketball Breaks Nine-Year Drought, Advances to Conference Playoffs • Four for Four: Ursinus Women\u27s Swimming Caps Off Perfect Four Yearshttps://digitalcommons.ursinus.edu/grizzlynews/1662/thumbnail.jp
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