Fuzzy hyperalgebras and direct product

We introduce and study the direct product of a family of fuzzy hyperalgebras of the same type and present some properties of it.

Term Functions and Fundamental Relation of Fuzzy Hyperalgebras

We introduce and study term functions over fuzzy hyperalgebras. We start from this idea that the set of nonzero fuzzy subsets of a fuzzy hyperalgebra can be organized naturally as a universal algebra, and constructing the term functions over this algebra. We present the form of generated subfuzzy hyperalgebra of a given fuzzy hyperalgebra as a generalization of universal algebras and multialgebras. Finally, we characterize the form of the fundamental relation of a fuzzy hyperalgebra

Modelling and simulation of advanced semiconductor devices

This paper presents a modelling and simulation study of advanced semiconductor devices. Different Technology Computer Aided Design approaches and models, used in nowadays research are described here. Our discussions are based on numerous theoretical approaches starting from first principle methods and continuing with discussions based on more well stablished methods such as Drift-Diffusion, Monte Carlo and Non-Equilibrium Green’s Function formalism

Performance of Vertically Stacked Horizontal Si Nanowires Transistors: A 3D Monte Carlo / 2D Poisson Schrodinger Simulation Study

In this paper we present a simulation study of 5nm vertically stacked lateral nanowires transistor (NWTs). The study is based on calibration of drift-diffusion results against a Poisson-Schrodinger simulations for density-gradient quantum corrections, and against ensemble Monte Carlo simulations to calibrate carrier transport. As a result of these calibrated results, we have established a link between channel strain and the device performance. Additionally, we have compared the current flow in a single, double and triple vertically stacked lateral NWTs

The Cut-off Values of Triglycerides - Glucose Index for Metabolic Syndrome Associated with Type 2 Diabetes Mellitus

يؤدي حدوث متلازمة الأيض مع داء السكري من النوع 2 الى زيادة شدة المرض والوفيات المرتبطة بكل منهما. يوصى باستخدام مؤشر الجلوكوز الصائم للدهون الثلاثية (مؤشر TyG) كعلامة مفيدة للتنبؤ بمتلازمة التمثيل الغذائي. كان الهدف من هذه الدراسة هو تحديد القيم الحدية لنوع Triglyceride-Glucose لتشخيص متلازمة الأيض في داء السكري من النوع الثاني. تم جمع البيانات من مستشفيات بغداد في الفترة ما بين مايو وديسمبر 2019. وكان عدد المشاركين المؤهلين 424 حيث تم قياس الجلوكوز في الدم في وضع الصيام ، مستوى الدهون ، مستوى HbA1c. فضلا عن قياس ضغط الدم وتم حساب مؤشر Triglyceride-Glucose . تم الحصول على الموافقة الأخلاقية والموافقة المستنيرة .استخدم برنامج SPSS لمعالجة البيانات. أظهر مرضى السكري الذين يعانون من متلازمة الأيض زيادة مستوى مؤشر TyG. ازداد انتشار متلازمة الأيض مع زيادة مؤشر TyG. أظهر مؤشر TyG ارتباطًا كبيرًا مع جميع مكونات متلازمة الأيض. حيث ارتبط طرديا مع مستوى الكاوكوز في الدم ومحيط الخصر ,مستوى الدهون وضغط الدم الانبساطي بينما تناسب عكسيا مع مستوى الكولسترول النافع .مقدار قيمة القطع الأمثل للمؤشر كانت 9.14 ، 9.28 للذكور والإناث على التوالي.نستنج من الدراسة ان مؤشر TyG ملائم للكشف عن متلازمة الأيض في داء السكري من النوع الثاني       The co-occurrence of metabolic syndrome with type 2 diabetes mellitus (T2DM) will potentiate the morbidity and mortality that may be associated with each case. Fasting triglycerides-glucose index (TyG index) has been recommended as a useful marker to predict metabolic syndrome. Our study aimed to introduce gender-specific cut-off values of triglycerides- glucose index   for diagnosing metabolic syndrome associated with type 2 diabetes mellitus. The data were collected from Baghdad hospitals between May - December 2019. The number of eligible participants was 424. National cholesterol education program, Adult Treatment Panel III criteria were used to define metabolic syndrome. Measurement of fasting blood glucose, lipid profile, HbA1c level, blood pressure, and anthropometric were done and the triglyceride-glucose index was calculated. Ethical approval and informed consent were obtained .SPSS was used to analyze the data. Diabetic patients with metabolic syndrome showed an increased level of TyG Index. The prevalence of metabolic syndrome increased with increased TyG index quartiles. The TyG-Index showed significant correlations with all components of metabolic syndrome. The optimal cut-off value revealed 9.14, 9.28 for males and females respectively. In conclusion, TyG index is a good predictor of the presence of MetS in T2DM the TyG index, just measured in one laboratory test, is simple, informative and more suitable for the detection of metabolic syndrome in Iraqi type 2 diabetes mellitus

Simulation of VSPT Experimental Cascade Under High and Low Free-Stream Turbulence Conditions

Variable-Speed Power Turbines (VSPT) for rotorcraft applications operate at low Reynolds number and over a wide range in incidence associated with shaft speed change. A comprehensive linear cascade data set obtained includes the effects of Reynolds number, free-stream turbulence and incidence is available and this paper concerns itself with the presentation and numerical simulation of conditions resulting in a selected set of those data. As such, post-dictions of blade pressure loading, total-pressure loss and exit flow angles under conditions of high and low turbulence intensity for a single Reynolds number are presented. Analyses are performed with the three-equation turbulence models of Walters- Leylek and Walters and Cokljat. Transition, loading, total-pressure loss and exit angle variations are presented and comparisons are made with experimental data as available. It is concluded that at the low freestream turbulence conditions the Walters-Cokljat model is better suited to predictions while for high freestream conditions the two models generate similar predications that are generally satisfactory

Circulating tumour cells demonstrate an altered response to hypoxia and an aggressive phenotype

BACKGROUND: Tumours contain hypoxic regions that select for an aggressive cell phenotype; tumour hypoxia induces metastasis-associated genes. Treatment refractory patients with metastatic cancer show increased numbers of circulating tumour cells (CTCs), which are also associated with disease progression. The aim of this study was to examine the as yet unknown relationship between hypoxia and CTCs. METHODS: We generated human MDA-MB-231 orthotopic xenografts and, using a new technology, isolated viable human CTCs from murine blood. The CTCs and parental MDA-MB-231 cells were incubated at 21 and 0.2% (hypoxia) oxygen, respectively. Colony formation was assayed and levels of hypoxia- and anoxia-inducible factors were measured. Xenografts generated from CTCs and parental cells were compared. RESULTS: MDA-MB-231 xenografts used to generate CTCs were hypoxic, expressing hypoxia factors: hypoxia-inducible factor1 alpha (HIF1alpha) and glucose transporter protein type 1 (GLUT1), and anoxia-induced factors: activating transcription factor 3 and 4 (ATF3 and ATF4). Parental MDA-MB-231 cells induced ATF3 in hypoxia, whereas CTCs expressed it constitutively. Asparagine synthetase (ASNS) expression was also higher in CTCs. Hypoxia induced ATF4 and the HIF1alpha target gene apelin in CTCs, but not in parental cells. Hypoxia induced lower levels of carbonic anhydrase IX (CAIX), GLUT1 and BCL2/adenovirus E1B 19-KD protein-interacting protein 3 (BNIP3) proteins in CTCs than in parental cells, supporting an altered hypoxia response. In chronic hypoxia, CTCs demonstrated greater colony formation than parental cells. Xenografts generated from CTCs were larger and heavier, and metastasised faster than MDA-MB-231 xenografts. CONCLUSION: CTCs show an altered hypoxia response and an enhanced aggressive phenotype in vitro and in vivo

Nanowire transistor solutions for 5nm and beyond

In this paper we present a comprehensive computational study of silicon nanowire transistor (SNT) and a SNM SRAM cell based on advanced design technology co-optimization (DTCO) TCAD tools. Utilizing this methodology, we provide guidelines and solutions for 5 nm and beyond in CMOS technology. At first, drift-diffusion (DD) results are fully calibrated against a Poisson-Schrodinger (PS) solution to calibrate density-gradient quantum corrections, and ensemble Monte Carlo (EMC) simulations to calibrate transport models. The calibrated DD gives us the capability to simulate statistical variability in nanowire transistors of the 5nm node and beyond accurately and efficiently. Various SNT structures are evaluated in terms of device figures of merit, and optimization of SNTs in terms of electrostatics driven performance is carried out. A variability-aware hierarchical compact model approach for SNT is adopted and used for statistical SRAM simulation near the scaling limit. The scaling of SNTs beyond the 5 nm is also discussed. ? 2016 IEEE.EI269-2742016-Ma

The Challenges of Adopting PLM Tools Involving Diversified Technologies in Today’s Automotive Supplier Business

In order to reduce product development (PD) costs and duration, PD cycles are being accelerated in order to reduce the time to market and satisfy the end customer needs. Another key challenge in PD today, is product diversification in the technologies used, requiring improved collaboration amongst local and dispersed multi disciple PD teams. A main stream tool that aids and support engineers in PD to collaborate and share information/knowledge is Product Lifecycle Management (PLM). This research explores the benefits and requirements of implementing a PLM system for a PD and manufacturing company within the automotive supply chain. This paper first provides a brief background of the subject area, followed by an explanation of the initial industrial investigation for the implementation of a PLM system, from which investigation the resulting conclusions and recommendations are presented as the building blocks of the implementation project