Personnel techniques necessary to maximize bio-barrier integrity at a Martian receiving laboratory

The planning of biological isolation measures for the Mars Surface Sample Return Mission is discussed in terms of personnel and organizational management. Deficiencies in past operation of the Lunar Receiving Laborator are analyzed. It was found that the failure to clearly define relationship among the government agencies involved and to effectively integrate their objectives and responsibilities was a major cause of Laboratory deficiencies. Possible solutions to these problems are presented for application to future missions

Organizational strategies for protection against back contamination

The organizational issues pertaining to the prevention of inbound contamination associated with possible Viking missions to Mars are considered. The completed Apollo missions, which returned samples from the moon, provide a convenient base for analysis of inbound contamination issues. Despite concern over the threat of inbound contamination from the moon and efforts to prevent back contamination, the back contamination efforts in the Apollo missions were considered ineffective had these missions encountered living organisms. Several alternatives for consideration in the design of future programs dealing with back contamination are examined and proposed for special consideration

Exploring the Problem-Finding and Problem-Solving Approach for Designing Organizations

An emerging problem-finding and problem-solving approach suggests that management's discovering problems to solve, opportunities to seize, and challenges to respond to, are vital to organizations. This paper explores the extent to which the problem-finding and problem-solving approach can provide a foundation for joining the capabilities, dynamic capabilities, and governance perspectives as a way to help scholars and practitioners to coherently design organizations from the perspective of design science. The problem-finding and problem-solving approach offers a unit of analysis and a set of behavioral assumptions that enable us to address open questions within the extant literature and to propose new questions in management research.

Detection of the old stellar component of the major Galactic bar

We present near-IR colour--magnitude diagrams and star counts for a number of regions along the Galactic plane. It is shown that along the l=27 b=0 line of sight there is a feature at 5.7 +-0.7kpc with a density of stars at least a factor two and probably more than a factor five times that of the disc at the same position. This feature forms a distinct clump on an H vs. J-H diagram and is seen at all longitudes from the bulge to about l=28, but at no longitude greater than this. The distance to the feature at l=20 is about 0.5kpc further than at l=27 and by l=10 it has merged with, or has become, the bulge. Given that at l=27 and l=21 there is also a clustering of very young stars, the only component that can reasonably explain what is seen is a bar with half length of around 4kpc and a position angle of about 43+-7.Comment: 5 pages, 5 figures accepted as a letter in MNRA

Low frequency VLBI in space using GAS-Can satellites: Report on the May 1987 JPL Workshop

Summarized are the results of a workshop held at JPL on May 28 and 29, 1987, to study the feasibility of using small, very inexpensive spacecraft for a low-frequency radio interferometer array. Many technical aspects of a mission to produce high angular resolution images of the entire sky at frequencies from 2 to 20 MHz were discussed. The workshop conclusion was that such a mission was scientifically valuable and technically practical. A useful array could be based on six or more satellites no larger than those launched from Get-Away-Special canisters. The cost of each satellite could be $1-2M, and the mass less than 90 kg. Many details require further study, but as this report shows, there is good reason to proceed. No fundamental problems have been discovered involving the use of untraditional, very inexpensive spacecraft for this type of mission

Random Projections For Large-Scale Regression

Fitting linear regression models can be computationally very expensive in large-scale data analysis tasks if the sample size and the number of variables are very large. Random projections are extensively used as a dimension reduction tool in machine learning and statistics. We discuss the applications of random projections in linear regression problems, developed to decrease computational costs, and give an overview of the theoretical guarantees of the generalization error. It can be shown that the combination of random projections with least squares regression leads to similar recovery as ridge regression and principal component regression. We also discuss possible improvements when averaging over multiple random projections, an approach that lends itself easily to parallel implementation.Comment: 13 pages, 3 Figure

Monitoring What Governments “Give for” and “Spend on” Vaccine Procurement: Vaccine Procurement Assistance and Vaccine Procurement Baseline

Background: The Global Vaccine Action Plan will require, inter alia, the mobilization of financial resources from donors and national governments – both rich and poor. Vaccine Procurement Assistance (VPA) and Vaccine Procurement Baseline (VPB) are two metrics that could measure government performance and track resources in this arena. VPA is proposed as a new subcategory of Official Development Assistance (ODA) given for the procurement of vaccines and VPB is a previously suggested measure of the share of Gross Domestic Product (GDP) that governments spend on their own vaccine procurement. Objective: To determine realistic targets for VPA and VPB. Methods: Organization for Economic Co-Operation and Development (OECD) and World Bank data for 2009 were analyzed to determine the proportions of bilateral ODA from the 23 Development Assistance Committee (DAC) countries disbursed (as % of GDP in current US$) for infectious disease control. DAC country contributions to the GAVI Alliance for 2009 were assessed as a measure of multilateral donor support for vaccines and immunization programs. Findings: In 2009, total DAC bilateral ODA was 0.16$7.61 billion and 0.02% of the GDP of the poorest 117 countries was US$2.88 billion. Conclusions: Adopting 0.02% GDP as minimum targets for both VPA and VPB is based on realistic estimates of what both developed and developing countries should spend, and can afford to spend, to jointly ensure procurement of vaccines recommended by national and global bodies. New OECD purpose codes are needed to specifically track ODA disbursed for a) vaccine procurement; and b) immunization programs

The relationship of individual comorbid chronic conditions to diabetes care quality.

ObjectiveMultimorbidity affects 26 million persons with diabetes, and care for comorbid chronic conditions may impact diabetes care quality. The aim of this study was to determine which chronic conditions were related to lack of achievement or achievement of diabetes care quality goals to determine potential targets for future interventions.Research design and methodsThis is an exploratory retrospective analysis of electronic health record data for 23 430 adults, aged 18-75, with diabetes who were seen at seven Midwestern US health systems. The main outcome measures were achievement of six diabetes quality metrics in the reporting year, 2011 (glycated haemoglobin (HbA1c) control and testing, low-density lipoprotein control and testing, blood pressure control, kidney testing). Explanatory variables were 62 chronic condition indicators. Analyses were adjusted for baseline patient sociodemographic and healthcare utilization factors.ResultsThe 62 chronic conditions varied in their relationships to diabetes care goal achievement for specific care goals. Congestive heart failure was related to lack of achievement of cholesterol management goals. Obesity was related to lack of HbA1c and BP control. Mental health conditions were related to both lack of achievement and achievement of different care goals. Three conditions were related to lack of cholesterol testing, including congestive heart failure and substance-use disorders. Of 17 conditions related to achieving control goals, 16 were related to achieving HbA1c control. One-half of the comorbid conditions did not predict diabetes care quality.ConclusionsFuture interventions could target patients at risk for not achieving diabetes care for specific care goals based on their individual comorbidities

Intellectual Property Management in Health and Agricultural Innovation: Executive Guide

Prepared by and for policy-makers, leaders of public sector research establishments, technology transfer professionals, licensing executives, and scientists, this online resource offers up-to-date information and strategies for utilizing the power of both intellectual property and the public domain. Emphasis is placed on advancing innovation in health and agriculture, though many of the principles outlined here are broadly applicable across technology fields. Eschewing ideological debates and general proclamations, the authors always keep their eye on the practical side of IP management. The site is based on a comprehensive Handbook and Executive Guide that provide substantive discussions and analysis of the opportunities awaiting anyone in the field who wants to put intellectual property to work. This multi-volume work contains 153 chapters on a full range of IP topics and over 50 case studies, composed by over 200 authors from North, South, East, and West. If you are a policymaker, a senior administrator, a technology transfer manager, or a scientist, we invite you to use the companion site guide available at http://www.iphandbook.org/index.html The site guide distills the key points of each IP topic covered by the Handbook into simple language and places it in the context of evolving best practices specific to your professional role within the overall picture of IP management