1,621 research outputs found
Allograft and Xenograft Acceptance under FK‐506 and Other Immunosuppressant Treatment
We will focus on two issues, both involving, but not confined to FK-506: first, the meaning of the graft acceptance, which is, after all, the objective of immunosuppression for the transplant surgeon; and second, how to take the next great step of xenotransplantation
Different photolysis kinetics at the surface of frozen freshwater vs. frozen salt solutions
Reactions at air-ice interfaces can proceed at very different rates than those in aqueous solution, due to the unique disordered region at the ice surface known as the quasi-liquid layer (QLL) . The physical and chemical nature of the surfacial region of ice is greatly affected by solutes such as sodium halide salts. In this work, we studied the effects of sodium chloride and sodium bromide on the photolysis kinetics of harmine, an aromatic organic compound, in aqueous solution and at the surface of frozen salt solutions above the eutectic temperature. In common with other aromatic organic compounds we have studied, harmine photolysis is much faster on ice surfaces than in aqueous solution, but the presence of NaCl or NaBr – which does not affect photolysis kinetics in solution – reduces the photolysis rate on ice. The rate decreases monotonically with increasing salt concentration; at the concentrations found in seawater, harmine photolysis at the surface of frozen salt solutions proceeds at the same rate as in aqueous solution. These results suggest that the brine excluded to the surfaces of frozen salt solutions is a true aqueous solution, and so it may be possible to use aqueous-phase kinetics to predict photolysis rates at sea ice surfaces. This is in marked contrast to the result at the surface of frozen freshwater samples, where reaction kinetics are often not well-described by aqueous-phase processes
A Randomized Controlled Trial on Very Early Speech and Language Therapy in Acute Stroke Patients with Aphasia
Background: Aphasia affects one third of acute stroke patients. There is a considerable spontaneous recovery in aphasia, but impaired communication ability remains a great problem. Communication difficulties are an impediment to rehabilitation. Early treatment of the language deficits leading to increased communication ability would improve rehabilitation. The aim of this study is to elucidate the efficacy of very early speech and language therapy (SLT) in acute stroke patients with aphasia. Methods: A prospective, open, randomized, controlled trial was carried out with blinded endpoint evaluation of SLT, starting within 2 days of stroke onset and lasting for 21 days. 123 consecutive patients with acute, first-ever ischemic stroke and aphasia were randomized. The SLT treatment was Language Enrichment Therapy, and the aphasia tests used were the Norsk grunntest for afasi (NGA) and the Amsterdam-Nijmegen everyday language test (ANELT), both performed by speech pathologists, blinded for randomization. Results: The primary outcome, as measured by ANELT at day 21, was 1.3 in the actively treated patient group and 1.2 among controls. NGA led to similar results in both groups. Patients with a higher level of education (>12 years) improved more on ANELT by day 21 than those with Conclusions: Very early intensive SLT with the Language Enrichment Therapy program over 21 days had no effect on the degree of aphasia in unselected acute aphasic stroke patients. In aphasic patients with more fluency, SLT resulted in a significant improvement as compared to controls. A higher educational level of >12 years was beneficial
Simple model for the vibrations of embedded elastically cubic nanocrystals
The purpose of this work is to calculate the vibrational modes of an
elastically anisotropic sphere embedded in an isotropic matrix. This has
important application to understanding the spectra of low-frequency Raman
scattering from nanoparticles embedded in a glass matrix. First some low
frequency vibrational modes of a free cubically elastic sphere are found to be
nearly independent of one combination of elastic constants. This is then
exploited to obtain an isotropic approximation for these modes which enables to
take into account the surrounding isotropic matrix. This method is then used to
quantatively explain recent spectra of gold and copper nanocrystals in glasses.Comment: 6 pages, 5 figure
Core pinning by intragranular nanoprecipitates in polycrystalline MgCNi_3
The nanostructure and magnetic properties of polycrystalline MgCNi_3 were
studied by x-ray diffraction, electron microscopy, and vibrating sample
magnetometry. While the bulk flux-pinning force curve F_p(H) indicates the
expected grain-boundary pinning mechanism just below T_c = 7.2 K, a systematic
change to pinning by a nanometer-scale distribution of core pinning sites is
indicated by a shift of F_p(H) with decreasing temperature. The lack of scaling
of F_p(H) suggests the presence of 10 to 20% of nonsuperconducting regions
inside the grains, which are smaller than the diameter of fluxon cores 2xi at
high temperature and become effective with decreasing temperature when xi(T)
approaches the nanostructural scale. Transmission electron microscopy revealed
cubic and graphite nanoprecipitates with 2 to 5 nm size, consistent with the
above hypothesis since xi(0) = 6 nm. High critical current densities, more than
10^6 A/cm^2 at 1 T and 4.2 K, were obtained for grain colonies separated by
carbon. Dirty-limit behavior seen in previous studies may be tied to electron
scattering by the precipitates, indicating the possibility that strong core
pinning might be combined with a technologically useful upper critical field if
versions of MgCNi_3 with higher T_c can be found.Comment: 5 pages, 6 figures, submitted to PR
The Safety of Using Body-Transmit MRI in Patients with Implanted Deep Brain Stimulation Devices
Deep brain stimulation (DBS) is an established treatment for patients with movement disorders. Patients receiving chronic DBS provide a unique opportunity to explore the underlying mechanisms of DBS using functional MRI. It has been shown that the main safety concern with MRI in these patients is heating at the electrode tips - which can be minimised with strict adherence to a supervised acquisition protocol using a head-transmit/receive coil at 1.5T. MRI using the body-transmit coil with a multi-channel receive head coil has a number of potential advantages including an improved signal-to-noise ratio
The efficacy of indwelling pleural catheter placement versus placement plus talc sclerosant in patients with malignant pleural effusions managed exclusively as outpatients (IPC-PLUS): study protocol for a randomised controlled trial
BACKGROUND: Malignant pleural effusions (MPEs) remain a common problem, with 40,000 new cases in the United Kingdom each year and up to 250,000 in the United States. Traditional management of MPE usually involves an inpatient stay with placement of a chest drain, followed by the instillation of a pleural sclerosing agent such as talc, which aims to minimise further fluid build-up. Despite a good success rate in studies, this approach can be expensive, time-consuming and inconvenient for patients. More recently, an alternative method has become available in the form of indwelling pleural catheters (IPCs), which can be inserted and managed in an outpatient setting. It is currently unknown whether combining talc pleurodesis with IPCs will provide improved pleural symphysis rates over those of IPCs alone.
METHODS/DESIGN: IPC-PLUS is a patient-blind, multicentre randomised controlled trial (RCT) comparing the combination of talc with an IPC to the use of an IPC alone for inducing pleurodesis in MPEs. The primary outcome is successful pleurodesis at five weeks post-randomisation. This study will recruit 154 patients, with an interim analysis for efficacy after 100 patients, and aims to help to define the future gold standard for outpatient management of patients with symptomatic MPEs.
DISCUSSION: IPC-PLUS is the first RCT to examine the practicality and utility of talc administered via an IPC. The study remains in active recruitment and has the potential to significantly alter how patients requiring pleurodesis for MPE are approached in the future.
TRIAL REGISTRATION: This trial was registered with Current Controlled Trials (identifier: ISRCTN73255764) on 23 August 2012
Future aspects of renal transplantation
New and exciting advances in renal transplantation are continuously being made, and the horizons for organ transplantation are bright and open. This article reviews only a few of the newer advances that will allow renal transplantation to become even more widespread and successful. The important and exciting implications for extrarenal organ transplantation are immediately evident. © 1988 Springer-Verlag
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