Three-dimensional analytical magnetohydrostatic equilibria of rigidly rotating magnetospheres in cylindrical geometry

We present three-dimensional solutions of the magnetohydrostatic equations in the co-rotating frame of reference outside a magnetized rigidly rotating cylinder. We make no symmetry assumption for the magnetic field, but to be able to make analytical progress we neglect outflows and specify a particular form for the current density. The magnetohydrostatic equations can then be reduced to a single linear partial differential equation for a pseudo-potential $U$, from which the magnetic field can be calculated by differentiation. The equation for $U$ can be solved by standard methods. The solutions can also be used to determine the plasma pressure, density and temperature as functions of all three spatial coordinates. Despite the obvious limitations of this approach, it can for example be used as a simple tool to create three-dimensional models for the closed field line regions of rotating magnetospheres without rotational symmetry.Comment: 13 pages, 2 figures, accepted for publication by Geophysical and Astrophysical Fluid Dynamic

Gauge Group and Topology Change

The purpose of this study is to examine the effect of topology change in the initial universe. In this study, the concept of $G$-cobordism is introduced to argue about the topology change of the manifold on which a transformation group acts. This $G$-manifold has a fiber bundle structure if the group action is free and is related to the spacetime in Kaluza-Klein theory or Einstein-Yang-Mills system. Our results revealed that fundamental processes of compactification in $G$-manifolds. In these processes, the initial high symmetry and multidimensional universe changes to present universe by the mechanism which lowers the dimensions and symmetries.Comment: 8 page

Feeding ancient cities in South Asia: Dating the adoption of rice, millet and tropical pulses in the Indus civilisation

© Antiquity Publications Ltd, 2016.The first direct absolute dates for the exploitation of several summer crops by Indus populations are presented here. These include rice, millets and three tropical pulse species at two settlements in the hinterland of the urban site of Rakhigarhi. The dates confirm the role of native summer domesticates in the rise of Indus cities. They demonstrate that, from their earliest phases, a range of crops and variable strategies, including multi-cropping, were used to feed different urban centres. This has important implications for understanding the development of the earliest cities in South Asia, particularly the organisation of labour and provisioning throughout the year.UK India Education and Research Initiative (Standard Award), British Academy (Stein Arnold Fund and International Mobility Scheme), Isaac Newton Trust, McDonald Institute for Archaeological Research, Natural Environment Research Council (NERC Radiocarbon Facility (Project IDs: NF/2009/2/7, NF/2013/1/6)), Arts and Humanities Research Council (Studentship), Trinity College (University of Cambridge), Division of Archaeology, Department of Archaeology and Anthropology (University of Cambridge

Effect of Hydro-Resistance Training on Bat Velocity

The purpose of this study was to determine the effect of hydro-resistance training on bat velocity during mimicked baseball swings in twenty-five female college students. Subjects were pre-tested for bat velocity and assigned to dry land (n = 8), water (n = 8), and control (n = 9) groups. The dry land group swung a 737 g (26 oz) Easton T1 Thunderstick baseball bat for three sets of 15 swings, three days per week, for eight weeks. The water group performed the swings in shoulder deep water. The dry land and water groups also participated in mandatory team general resistance training three days per week. The control group performed no bat swing or resistance-training regimens. Mean bat velocity was measured with an electronic eye-timing device. A 3 x 2 (Group x Time) ANOVA with repeated measures was used for statistical analysis, followed up with Tukey’s post hoc test. Bat velocity decreased significantly for the dry land and water groups (24.0 ± 3.6 m/s to 20.6 ± 4.1 m/s and 23.8 ± 3.5 to 18.8 ± 4.1 m/s, respectively). Bat velocity did not change for the control group (21.5 ± 3.0 m/s to 20.2 ± 2.1 m/s). We speculate that the decreased bat velocity in the dry land and water groups was caused by the mandatory team general resistance-training program

Magnetohydrostatic solar prominences in near-potential coronal magnetic fields

We present numerical magnetohydrostatic solutions describing the gravitationally stratified, bulk equilibrium of cool, dense prominence plasma embedded in a near-potential coronal field. These solutions are calculated using the FINESSE magnetohydrodynamics equilibrium solver and describe the morphologies of magnetic field distributions in and around prominences and the cool prominence plasma that these fields support. The equilibrium condition for this class of problem is usually different in distinct subdomains, separated by free boundaries, across which solutions are matched by suitable continuity or jump conditions describing force balance. We employ our precise finite element elliptic solver to calculate solutions not accessible by previous analytical techniques with temperature or entropy prescribed as free functions of the magnetic flux function, including a range of values of the polytropic index, temperature variations mainly across magnetic field lines and photospheric field profiles sheared close to the polarity inversion line. Out of the many examples computed here, perhaps the most noteworthy is one which reproduces precisely the three-part structure often encountered in observations: a cool dense prominence within a cavity/flux rope embedded in a hot corona. The stability properties of these new equilibria, which may be relevant to solar eruptions, can be determined in the form of a full resistive MHD spectrum using a companion hyperbolic stability solver.Comment: To appear in ApJ August 200

Association is not causation: treatment effects cannot be estimated from observational data in heart failure

Aims: Treatment ‘effects’ are often inferred from non-randomized and observational studies. These studies have inherent biases and limitations, which may make therapeutic inferences based on their results unreliable. We compared the conflicting findings of these studies to those of prospective randomized controlled trials (RCTs) in relation to pharmacological treatments for heart failure (HF). Methods and results: We searched Medline and Embase to identify studies of the association between non-randomized drug therapy and all-cause mortality in patients with HF until 31 December 2017. The treatments of interest were: angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, mineralocorticoid receptor antagonists (MRAs), statins, and digoxin. We compared the findings of these observational studies with those of relevant RCTs. We identified 92 publications, reporting 94 non-randomized studies, describing 158 estimates of the ‘effect’ of the six treatments of interest on all-cause mortality, i.e. some studies examined more than one treatment and/or HF phenotype. These six treatments had been tested in 25 RCTs. For example, two pivotal RCTs showed that MRAs reduced mortality in patients with HF with reduced ejection fraction. However, only one of 12 non-randomized studies found that MRAs were of benefit, with 10 finding a neutral effect, and one a harmful effect. Conclusion: This comprehensive comparison of studies of non-randomized data with the findings of RCTs in HF shows that it is not possible to make reliable therapeutic inferences from observational associations. While trials undoubtedly leave gaps in evidence and enrol selected participants, they clearly remain the best guide to the treatment of patients

Feeding ancient cities in South Asia: Dating the adoption of rice, millet and tropical pulses in the Indus civilisation

© Antiquity Publications Ltd, 2016.The first direct absolute dates for the exploitation of several summer crops by Indus populations are presented here. These include rice, millets and three tropical pulse species at two settlements in the hinterland of the urban site of Rakhigarhi. The dates confirm the role of native summer domesticates in the rise of Indus cities. They demonstrate that, from their earliest phases, a range of crops and variable strategies, including multi-cropping, were used to feed different urban centres. This has important implications for understanding the development of the earliest cities in South Asia, particularly the organisation of labour and provisioning throughout the year

Minimal basilar membrane motion in low-frequency hearing

Low-frequency hearing is critically important for speech and music perception, but no mechanical measurements have previously been available from inner ears with intact low-frequency parts. These regions of the cochlea may function in ways different from the extensively studied high-frequency regions, where the sensory outer hair cells produce force that greatly increases the sound-evoked vibrations of the basilar membrane. We used laser interferometry in vitro and optical coherence tomography in vivo to study the low-frequency part of the guinea pig cochlea, and found that sound stimulation caused motion of a minimal portion of the basilar membrane. Outside the region of peak movement, an exponential decline in motion amplitude occurred across the basilar membrane. The moving region had different dependence on stimulus frequency than the vibrations measured near the mechanosensitive stereocilia. This behavior differs substantially from the behavior found in the extensively studied high-frequency regions of the cochlea

Palliative care needs in patients hospitalized with heart failure (PCHF) study: rationale and design

Abstract Aims The primary aim of this study is to provide data to inform the design of a randomized controlled clinical trial (RCT) of a palliative care (PC) intervention in heart failure (HF). We will identify an appropriate study population with a high prevalence of PC needs defined using quantifiable measures. We will also identify which components a specific and targeted PC intervention in HF should include and attempt to define the most relevant trial outcomes. Methods An unselected, prospective, near-consecutive, cohort of patients admitted to hospital with acute decompensated HF will be enrolled over a 2-year period. All potential participants will be screened using B-type natriuretic peptide and echocardiography, and all those enrolled will be extensively characterized in terms of their HF status, comorbidity, and PC needs. Quantitative assessment of PC needs will include evaluation of general and disease-specific quality of life, mood, symptom burden, caregiver burden, and end of life care. Inpatient assessments will be performed and after discharge outpatient assessments will be carried out every 4 months for up to 2.5 years. Participants will be followed up for a minimum of 1 year for hospital admissions, and place and cause of death. Methods for identifying patients with HF with PC needs will be evaluated, and estimates of healthcare utilisation performed. Conclusion By assessing the prevalence of these needs, describing how these needs change over time, and evaluating how best PC needs can be identified, we will provide the foundation for designing an RCT of a PC intervention in HF

Atmospheric response in summer linked to recent Arctic sea ice loss

Since 2007 a large decline in Arctic sea ice has been observed. The large-scale atmospheric circulation response to this decline is investigated in ERA-Interim reanalyses and HadGEM3 climate model experiments. In winter, post-2007 observed circulation anomalies over the Arctic, North Atlantic and Eurasia are small compared to interannual variability. In summer, the post-2007 observed circulation is dominated by an anticyclonic anomaly over Greenland which has a large signal-to-noise ratio. Climate model experiments driven by observed SST and sea ice anomalies are able to capture the summertime pattern of observed circulation anomalies, although the magnitude is a third of that observed. The experiments suggest high SSTs and reduced sea ice in the Labrador Sea lead to positive temperature anomalies in the lower troposphere which weaken the westerlies over North America through thermal wind balance. The experiments also capture cyclonic anomalies over Northwest Europe, which are consistent with downstream Rossby wave propagatio