439 research outputs found
Explicit solution for a Gaussian wave packet impinging on a square barrier
The collision of a quantum Gaussian wave packet with a square barrier is
solved explicitly in terms of known functions. The obtained formula is suitable
for performing fast calculations or asymptotic analysis. It also provides
physical insight since the description of different regimes and collision
phenomena typically requires only some of the terms.Comment: To be published in J. Phys.
In vivo electrophysiological study of the targeting of 5-HT3 receptor-expressing cortical interneurons by the multimodal antidepressant, vortioxetine
This study was supported by an educational grant from H. Lundbeck A/S.The antidepressant vortioxetine has high affinity for the ionotropic 5-HT3 receptor (5-HT3R) as well as other targets including the 5-HT transporter. The procognitive effects of vortioxetine have been linked to altered excitatory:inhibitory balance in cortex. Thus, vortioxetine purportedly inhibits cortical 5-HT3R-expressing interneurons (5-HT3R-INs) to disinhibit excitatory pyramidal neurons. The current study determined for the first time, the effect of vortioxetine on the in vivo firing of putative 5-HT3R-INs whilst simultaneously recording pyramidal neuron activity using cortical slow-wave oscillations as a readout. Extracellular single unit and local field potential recordings were made in superficial layers of the prefrontal cortex of urethane-anaesthetised rats. 5-HT3R-INs were identified by a short-latency excitation evoked by electrical stimulation of the dorsal raphe nucleus (DRN). Juxtacellular-labelling found such neurons had the morphological and immunohistochemical properties of 5-HT3R-INs; basket cell or bipolar cell morphology, expression of 5-HT3R-IN markers, and parvalbumin-immunonegative. Vortioxetine inhibited the short-latency DRN-evoked excitation of 5-HT3R-INs and simultaneously decreased cortical slow wave oscillations, indicative of pyramidal neuron activation. Likewise, the 5-HT3R antagonist ondansetron inhibited the short-latency DRN-evoked excitation of 5-HT3R-INs. However unlike vortioxetine, ondansetron did not decrease cortical slow-wave oscillations suggesting a dissociation between this effect and inhibition of 5-HT3R-INs. The 5-HT reuptake inhibitor escitalopram had no consistent effect on any electrophysiological parameter measured. Overall, the current findings suggest that vortioxetine simultaneously inhibits (DRN-evoked) 5-HT3R-INs and excites pyramidal neurons, thereby changing the excitatory:inhibitory balance in cortex. However, under the current experimental conditions these two effects were dissociable with only the former likely involving a 5-HT3R-mediated mechanism.Publisher PDFPeer reviewe
Reduced dimensionality spin-orbit dynamics of CH3 + HCl reversible arrow CH4 Cl on ab initio surfaces
A reduced dimensionality quantum scattering method is extended to the study of spin-orbit nonadiabatic transitions in the CH3 + HCl reversible arrow CH4 + Cl(P-2(J)) reaction. Three two-dimensional potential energy surfaces are developed by fitting a 29 parameter double-Morse function to CCSD(T)/IB//MP2/cc-pV(T+d)Z-dk ab initio data; interaction between surfaces is described by geometry-dependent spin-orbit coupling functions fit to MCSCF/cc-pV(T+d)Z-dk ab initio data. Spectator modes are treated adiabatically via inclusion of curvilinear projected frequencies. The total scattering wave function is expanded in a vibronic basis set and close-coupled equations are solved via R-matrix propagation. Ground state thermal rate constants for forward and reverse reactions agree well with experiment. Multi-surface reaction probabilities, integral cross sections, and initial-state selected branching ratios all highlight the importance of vibrational energy in mediating nonadiabatic transition. Electronically excited state dynamics are seen to play a small but significant role as consistent with experimental conclusions. (C) 2011 American Institute of Physics. [doi:10.1063/1.3592732
Time scale of forerunners in quantum tunneling
The forerunners preceding the main tunneling signal of the wave created by a
source with a sharp onset or by a quantum shutter, have been generally
associated with over-the-barrier (non-tunneling) components. We demonstrate
that, while this association is true for distances which are larger than the
penetration lenght, for smaller distances the forerunner is dominated by
under-the-barrier components. We find that its characteristic arrival time is
inversely proportional to the difference between the barrier energy and the
incidence energy, a tunneling time scale different from both the phase time and
the B\"uttiker-Landauer (BL) time.Comment: Revtex4, 14 eps figure
Quantile Motion and Tunneling
The concepts of quantile position, trajectory, and velocity are defined. For
a tunneling quantum mechanical wave packet, it is proved that its quantile
position always stays behind that of a free wave packet with the same initial
parameters. In quantum mechanics the quantile trajectories are mathematically
identical to Bohm's trajectories. A generalization to three dimensions is
given.Comment: 13 pages, LaTeX, elsart, 3 ps figures, submitted to Phys. Lett.
Composite absorbing potentials
The multiple scattering interferences due to the addition of several
contiguous potential units are used to construct composite absorbing potentials
that absorb at an arbitrary set of incident momenta or for a broad momentum
interval.Comment: 9 pages, Revtex, 2 postscript figures. Accepted in Phys. Rev. Let
A new potential energy surface for OH(A 2Σ+)–Kr: The van der Waals complex and inelastic scattering
New ab initio studies of the OH(A(2)ÎŁ(+))-Kr system reveal significantly deeper potential energy wells than previously believed, particularly for the linear configuration in which Kr is bound to the oxygen atom side of OH(A(2)ÎŁ(+)). In spite of this difference with previous work, bound state calculations based on a new RCCSD(T) potential energy surface yield an energy level structure in reasonable accord with previous studies. However, the new calculations suggest the need for a reassignment of the vibrational levels of the electronically excited complex. Quantum mechanical and quasi-classical trajectory scattering calculations are also performed on the new potential energy surface. New experimental measurements of rotational inelastic scattering cross sections are reported, obtained using Zeeman quantum beat spectroscopy. The values of the rotational energy transfer cross sections measured experimentally are in good agreement with those derived from the dynamical calculations on the new adiabatic potential energy surface
Tunneling dynamics in relativistic and nonrelativistic wave equations
We obtain the solution of a relativistic wave equation and compare it with
the solution of the Schroedinger equation for a source with a sharp onset and
excitation frequencies below cut-off. A scaling of position and time reduces to
a single case all the (below cut-off) nonrelativistic solutions, but no such
simplification holds for the relativistic equation, so that qualitatively
different ``shallow'' and ``deep'' tunneling regimes may be identified
relativistically. The nonrelativistic forerunner at a position beyond the
penetration length of the asymptotic stationary wave does not tunnel;
nevertheless, it arrives at the traversal (semiclassical or
B\"uttiker-Landauer) time "tau". The corresponding relativistic forerunner is
more complex: it oscillates due to the interference between two saddle point
contributions, and may be characterized by two times for the arrival of the
maxima of lower and upper envelops. There is in addition an earlier
relativistic forerunner, right after the causal front, which does tunnel.
Within the penetration length, tunneling is more robust for the precursors of
the relativistic equation
Matter-wave diffraction in time with a linear potential
Diffraction in time of matter waves incident on a shutter which is removed at
time is studied in the presence of a linear potential. The solution is
also discussed in phase space in terms of the Wigner function. An alternative
configuration relevant to current experiments where particles are released from
a hard wall trap is also analyzed for single-particle states and for a
Tonks-Girardeau gas.Comment: 11 pages, 6 figure
Secure Biometric Authentication With Improved Accuracy
We propose a new hybrid protocol for cryptographically secure biometric authentication. The main advantages of the proposed protocol over previous solutions can be summarised as follows: (1) potential for much better accuracy using different types of biometric signals, including behavioural ones; and (2) improved user privacy, since user identities are not transmitted at any point in the protocol execution. The new protocol takes advantage of state-of-the-art identification classifiers, which provide not only better accuracy, but also the possibility to perform authentication without knowing who the user claims to be. Cryptographic security is based on the Paillier public key encryption
scheme
- …