54,647 research outputs found

    Observation of a (2X8) surface reconstruction on Si_(1-x)Ge_x alloys grown on (100) Si by molecular beam epitaxy

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    We present evidence supporting the formation of a new, (2×8) surface reconstruction on Si_(1−x)Ge_x alloys grown on (100) Si substrates by molecular‐beam epitaxy. Surfaces of Si_(1−x)Ge_x alloys were studied using reflection high‐energy electron diffraction (RHEED) and low‐energy electron diffraction (LEED) techniques. RHEED patterns from samples with Ge concentrations, x, falling within the range 0.10–0.30 and grown at temperatures between 350 and 550 °C, exhibit n/8 fractional‐order diffraction streaks in addition to the normal (2×1) pattern seen on (100) Si. The presence of fractional‐order diffracted beams is indicative of an eight‐fold‐periodic modulation in electron scattering factor across the alloy surface. LEED patterns from surfaces of samples grown under similar conditions are entirely consistent with these results. In addition, the LEED patterns support the conclusion that the modulation is occurring in the direction of the dimer chains of a (2×1) reconstruction. We have examined the thermal stability of the (2×8) reconstruction and have found that it reverts to (2×1) after annealing to 700 °C and reappears after the sample temperature is allowed to cool below 600 °C. Such behavior suggests that the reconstruction is a stable, ordered phase for which the pair‐correlation function of surface Ge atoms exhibits an eightfold periodicity in the "1" direction of a Si‐like (2×1) reconstruction. We also present a simulation in the kinematic approximation, confirming the validity of our interpretation of these finding

    3-hydroxykynurenine suppresses CD4+ T-cell proliferation, induces T-regulatory-cell development, and prolongs corneal allograft survival

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    Copyright © 2011 Association for Research in Vision and Ophthalmology. This article is available open access through the publisher’s website at the link below.Purpose. IDO (indoleamine 2,3-dioxygenase) modulates the immune response by depletion of the essential amino acid tryptophan, and IDO overexpression has been shown to prolong corneal allograft survival. This study was conducted to examine the effect of kynurenines, the products of tryptophan breakdown and known to act directly on T lymphocytes, on corneal graft survival. Methods. The effects of kynurenines on T-cell proliferation and death, T-regulatory-cell development, and dendritic cell function, phenotype, and viability were analyzed in vitro. The effect of topical and systemic administration of 3-hydroxykynurenine (3HK) on orthotopic murine corneal allograft survival was examined. Results. T-lymphocyte proliferation was inhibited by two of the four different kynurenines: 3HK and 3-hydroxyanthranilic acid (3HAA). This effect was accompanied by significant T-cell death. Neither 3HK nor 3HAA altered dendritic cell function, nor did they induce apoptosis or pathogenicity to corneal endothelial cells. Administration of systemic and topical 3HK to mice receiving a fully mismatched corneal graft resulted in significant prolongation of graft survival (median survival of control grafts, 12 days; of treated, 19 and 15 days, respectively; P < 0.0003). While systemic administration of 3HK was associated with a significant depletion of CD4+ T, CD8+ T, and B lymphocytes in peripheral blood, no depletion was found after topical administration. Conclusions. The production of kynurenines, in particular 3HK and 3HAA, may be one mechanism (in addition to tryptophan depletion) by which IDO prolongs graft survival. These molecules have potential as specific agents for preventing allograft rejection in patients at high rejection risk.Fight for Sight and the Wellcome Trust

    DRS: Dynamic Resource Scheduling for Real-Time Analytics over Fast Streams

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    In a data stream management system (DSMS), users register continuous queries, and receive result updates as data arrive and expire. We focus on applications with real-time constraints, in which the user must receive each result update within a given period after the update occurs. To handle fast data, the DSMS is commonly placed on top of a cloud infrastructure. Because stream properties such as arrival rates can fluctuate unpredictably, cloud resources must be dynamically provisioned and scheduled accordingly to ensure real-time response. It is quite essential, for the existing systems or future developments, to possess the ability of scheduling resources dynamically according to the current workload, in order to avoid wasting resources, or failing in delivering correct results on time. Motivated by this, we propose DRS, a novel dynamic resource scheduler for cloud-based DSMSs. DRS overcomes three fundamental challenges: (a) how to model the relationship between the provisioned resources and query response time (b) where to best place resources; and (c) how to measure system load with minimal overhead. In particular, DRS includes an accurate performance model based on the theory of \emph{Jackson open queueing networks} and is capable of handling \emph{arbitrary} operator topologies, possibly with loops, splits and joins. Extensive experiments with real data confirm that DRS achieves real-time response with close to optimal resource consumption.Comment: This is the our latest version with certain modificatio

    Global modeling of secondary organic aerosol formation from aromatic hydrocarbons: high- vs low-yield pathways

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    Formation of SOA from the aromatic species toluene, xylene, and, for the first time, benzene, is added to a global chemical transport model. A simple mechanism is presented that accounts for competition between low and high-yield pathways of SOA formation, wherein secondary gas-phase products react further with either nitrogen oxide (NO) or hydroperoxy radical (HO2) to yield semi- or non-volatile products, respectively. Aromatic species yield more SOA when they react with OH in regions where the [NO]/[HO2] ratios are lower. The SOA yield thus depends upon the distribution of aromatic emissions, with biomass burning emissions being in areas with lower [NO]/[HO2] ratios, and the reactivity of the aromatic with respect to OH, as a lower initial reactivity allows transport away from industrial source regions, where [NO]/[HO2] ratios are higher, to more remote regions, where this ratio is lower and, hence, the ultimate yield of SOA is higher. As a result, benzene is estimated to be the most important aromatic species with regards to formation of SOA, with a total production nearly equal that of toluene and xylene combined. In total, while only 39% percent of the aromatic species react via the low-NOx pathway, 72% of the aromatic SOA is formed via this mechanism. Predicted SOA concentrations from aromatics in the Eastern United States and Eastern Europe are actually largest during the summer, when the [NO]/[HO2] ratio is lower. Global production of SOA from aromatic sources is estimated at 3.5 Tg/yr, resulting in a global burden of 0.08 Tg, twice as large as previous estimates. The contribution of these largely anthropogenic sources to global SOA is still small relative to biogenic sources, which are estimated to comprise 90% of the global SOA burden, about half of which comes from isoprene. Compared to recent observations, it would appear there are additional pathways beyond those accounted for here for production of anthropogenic SOA. However, owing to differences in spatial distributions of sources and seasons of peak production, there are still regions in which aromatic SOA produced via the mechanisms identified here are predicted to contribute substantially to, and even dominate, the local SOA concentrations, such as outflow regions from North America and South East Asia during the wintertime, though total SOA concentrations there are small (~0.1 μg/m^³)

    NMR Search for the Spin Nematic State in LaFeAsO Single Crystal

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    We report a 75-As single crystal NMR investigation of LaFeAsO, the parent phase of a pnictide high Tc superconductor. We demonstrate that spin dynamics develop a strong two-fold anisotropy within each orthorhombic domain below the tetragonal-orthorhombic structural phase transition at T[TO]~156 K. This intermediate state with a dynamical breaking of the rotational symmetry freezes progressively into a spin density wave (SDW) below T[SDW]~142 K. Our findings are consistent with the presence of a spin nematic state below T[TO] with an incipient magnetic order.Comment: Revised manuscript accepted for publication in Phys. Rev. Let

    Perceptually Motivated Wavelet Packet Transform for Bioacoustic Signal Enhancement

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    A significant and often unavoidable problem in bioacoustic signal processing is the presence of background noise due to an adverse recording environment. This paper proposes a new bioacoustic signal enhancement technique which can be used on a wide range of species. The technique is based on a perceptually scaled wavelet packet decomposition using a species-specific Greenwood scale function. Spectral estimation techniques, similar to those used for human speech enhancement, are used for estimation of clean signal wavelet coefficients under an additive noise model. The new approach is compared to several other techniques, including basic bandpass filtering as well as classical speech enhancement methods such as spectral subtraction, Wiener filtering, and Ephraim–Malah filtering. Vocalizations recorded from several species are used for evaluation, including the ortolan bunting (Emberiza hortulana), rhesus monkey (Macaca mulatta), and humpback whale (Megaptera novaeanglia), with both additive white Gaussian noise and environment recording noise added across a range of signal-to-noise ratios (SNRs). Results, measured by both SNR and segmental SNR of the enhanced wave forms, indicate that the proposed method outperforms other approaches for a wide range of noise conditions

    The Nature of Optical Features in the Inner Region of the 3C48 Host Galaxy

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    The well-known quasar 3C48 is the most powerful compact steep-spectrum radio-loud QSO at low redshifts. It also has two unusual optical features within the radius of the radio jet (~1"): (1) an anomalous, high-velocity narrow-line component, having several times as much flux as does the narrow-line component coinciding with the broad-line redshift; and (2) a bright continuum peak (3C48A) ~1" northeast of the quasar. Both of these optical features have been conjectured to be related to the radio jet. Here we explore these suggestions. We have obtained Gemini North GMOS integral-field-unit (IFU) spectroscopy of the central region around 3C48. We use the unique features of the IFU data to remove unresolved emission at the position of the quasar. The resolved emission at the wavelength of the high-velocity component is peaked <~0.25" north of the quasar, at virtually the same position angle as the base of the radio jet. These observations appear to confirm that this high-velocity gas is connected with the radio jet. However, most of the emission comes from a region where the jet is still well collimated, rather than from the regions where the radio maps indicate strong interaction with an external medium. We also present the results of HST STIS spectroscopy of 3C48A. We show that 3C48A is dominated by stars with a luminosity-weighted age of ~1.4 X 10^8 years, substantially older than any reasonable estimate for the age of the radio source. Our IFU data indicate a similar age. Thus, 3C48A almost certainly cannot be attributed to jet-induced star formation. The host galaxy of 3C48 is clearly the result of a merger, and 3C48A seems much more likely to be the distorted nucleus of the merging partner, in which star formation was induced during the previous close passage.Comment: 10 pages, accepted by The Astrophysical Journa
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