The Development of the Mindfulness for Mental Fitness Program (Mind-Fit): An Online Mindfulness-Based Cognitive Group Therapy Program for Anxiety and Depression among Filipino College Students

Primarily, the study was conducted to test the efficacy of a newly developed Online Mindfulness-Based Cognitive Group Therapy Program for Anxiety and Depression among Filipino College Students known as Mind-Fit Program. Using One Group Pretest-Posttest Design, participants underwent 5-sessions (5 weeks with 45 minutes-2 hours duration per week). Measures such as Hopkin’s Symptom Checklist (HSCL), Patient Health Questionnaire (PHQ-9), Beck Anxiety Inventory (BAI) and Connor-Davidson Resilience Scale 10 were used as pre and post-test measures. Both quantitative and qualitative approaches were used to analyze the data. Results revealed on the quantitative part using paired sample t-test and Cohen’s d that there is a significant difference on the pre and post-test results on Hopkins Anxiety scale (t(5) = 17.419, p = .000) and Beck Anxiety measure (t(5) = 5.466, p = .005) with Cohen's d of 4.60 and 3.42 respectively.  Same pattern was found on the difference of pre and post test on depression measures. Statistically significant findings on both Hopkins Depression subscale (t(5) = 7.359, p = .002) and PHQ-9 measure (t(5) = 5.466, p = .005) with Cohen’s d of 4.28 and 2.13 respectively

Engineering Transcriptional Regulator Effector Specificity using Computational Design and In Vitro Rapid Prototyping: Developing a Vanillin Sensor

The pursuit of circuits and metabolic pathways of increasing complexity and robustness in synthetic biology will require engineering new regulatory tools. Feedback control based on relevant molecules, including toxic intermediates and environmental signals, would enable genetic circuits to react appropriately to changing conditions. In this work, variants of qacR, a tetR family repressor, were generated by computational protein design and screened in a cell-free transcription–translation (TX-TL) system for responsiveness to a new targeted effector. The modified repressors target vanillin, a growth-inhibiting small molecule found in lignocellulosic hydrolysates and other industrial processes. Promising candidates from the in vitro screen were further characterized in vitro and in vivo in a gene circuit. The screen yielded two qacR mutants that respond to vanillin both in vitro and in vivo. While the mutants exhibit some toxicity to cells, presumably due to off-target effects, they are prime starting points for directed evolution toward vanillin sensors with the specifications required for use in a dynamic control loop. We believe this process, a combination of the generation of variants coupled with in vitro screening, can serve as a framework for designing new sensors for other target compounds

Structural and Thermal Performance Assessment of Shipping Container as Post-Disaster Housing in Tropical Climates

Shipping Containers (SC) are a viable option as temporary or permanent housing for disaster victims due to their modularity, strength, and availability in large quantities around the world. While SCs as alternative housing has been extensively explored, few studies have focused on the structural and thermal performance of SCs in a tropical monsoon climate. This paper aims to contribute to a better knowledge of SC building construction by (1) investigating the SCs structural performance when subjected to a variety of loads, including gravity, earthquake, and very strong typhoon, and (2) assessing the thermal performance in a hot and humid climate. The case of Leyte, Philippines, a hot, humid, and typhoon-frequented region, is considered in this study. To meet the objectives, two SCs were combined to build a single-family house. First, the structural strength of the SCs, including the effect of cuts and openings, were investigated using finite element analysis. Second, the thermal condition of the SC was compared using four models with different insulation materials: no insulation, PE foam insulation (R-12), slightly higher insulation (R-13 fiberglass batt), and very high insulation (R-49 fiberglass batt) through building energy simulation. The paper concludes that SCs have inherently high strength and can withstand strong wind and earthquake. Stresses due to cuts and openings were minimized when the cuts/openings were placed far from the corner posts. On the other hand, increasing insulation R-value did not improve the indoor thermal condition of the SCs. More work needs to be done on making SCs thermally comfortable in hot and humid climates. Doi: 10.28991/cej-2021-03091735 Full Text: PD

Thoracoscopic detection of occult indeterminate pulmonary nodules using bronchoscopic pleural dye marking

Background: The annual incidence of a small indeterminate pulmonary nodule (IPN) on computed tomography (CT) scan remains high. While traditional paradigms exist, the integration of new technologies into these diagnostic and treatment algorithms can result in alternative, potentially more efficient methods of managing these findings. Methods: We report on an alternative diagnostic and therapeutic strategy for the management of an IPN. This approach combines electromagnetic navigational bronchoscopy (ENB) with an updated approach to placement of a pleural dye marker. This technique lends itself to a minimally invasive wedge resection via either video-assisted thoracoscopic surgery (VATS) or a robotic approach. Results: Subsequent to alterations in the procedure, a cohort of 22 patients with an IPN was reviewed. Navigation was possible in 21 out of 22 patients with one patient excluded based on airway anatomy. The remaining 21 patients underwent ENB with pleural dye marking followed by minimally invasive wedge resection. The median size of the nodules was 13.4 mm (range: 7–29). There were no complications from the ENB procedure. Indigo carmine dye was used in ten patients. Methylene blue was used in the remaining 11 patients. In 81% of cases, the visceral pleural marker was visible at the time of surgery. In one patient, there was diffuse staining of the parietal pleura. In three additional patients, no dye was identified within the hemithorax. In all cases where dye marker was present on the visceral pleural surface, it was in proximity to the IPN and part of the excised specimen. Conclusions: ENB with pleural dye marking can provide a safe and effective method to localize an IPN and can allow for subsequent minimally invasive resection. Depending on the characteristics and location of the nodule, this method may allow more rapid identification intraoperatively

Hairs on the cosmological horizon

We investigate the possibility of having hairs on the cosmological horizon. The cosmological horizon shares similar properties of black hole horizons in the aspect of having hairs on the horizons. For those theories admitting haired black hole solutions, the nontrivial matter fields may reach and extend beyond the cosmological horizon. For Q-stars and boson stars, the matter fields cannot reach the cosmological horizon. The no short hair conjecture keeps valid, despite the asymptotic behavior (de Sitter or anti-de Sitter) of black hole solutions. We prove the no scalar hair theorem for anti-de Sitter black holes. Using the Bekenstein's identity method, we also prove the no scalar hair theorem for the de Sitter space and de Sitter black holes if the scalar potential is convex.Comment: Revtex, no figures, 16 page

Hairy black holes in theories with massive gravitons

This is a brief survey of the known black hole solutions in the theories of ghost-free bigravity and massive gravity. Various black holes exist in these theories, in particular those supporting a massive graviton hair. However, it seems that solutions which could be astrophysically relevant are the same as in General Relativity, or very close to them. Therefore, the no-hair conjecture essentially applies, and so it would be hard to detect the graviton mass by observing black holes.Comment: References added. 20 pages, 3 figures, based on the talk given at the 7-th Aegean Summer School "Beyond Einstein's theory of gravity", September 201

Adaptive hypermedia driven serious game design and cognitive style in school settings: an exploratory study

The potential value of adaptive hypermedia and game based learning to education and training has long been recognised, numerous studies have been undertaken in both those areas investigating its potential to improve learner performance. In particular research has indicated that tailoring content to match the prior knowledge of the user has the power to increase the effectiveness of learning systems. Recent studies have begun to indicate that Adaptive Hypermedia Learning Systems (AHLS) based on cognitive styles have the power to improve learner performance. Recent examples of research exploring avenues for effectively incorporating serious games into AHLS indicated that integrating serious games into a personalized learning environment has the potential educational benefits of combining a personalized delivery with increased learner motivation. The exploratory study presented in this paper here developed an Adaptive Hypermedia Driven Serious Game (AHDSG) based around Pask’s Holist-Serialist dimension of cognitive style. A prototype AHDSG was designed and developed to teach students about Sutton Hoo and archaeological methods. Sixty-six secondary school students participated in this study. Overall the findings of this study show that there was an improvement in performance among all participants. Although the participants that used the system which adapted to their preferred cognitive style achieved a higher mean gain score, the difference was not significant

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

Guidance on the assessment of the safety of feed additives for the environment

This guidance document is intended to assist the applicant in the preparation and the presentation of an application, as foreseen in Article 7.6 of Regulation (EC) No 1831/2003, for the authorisation of additives used in animal nutrition. It specifically covers the assessment of the safety for the environment. (Table presented.)