Deceleration of Relativistic Radio Components and the morphologies of Gigahertz Peaked Spectrum Sources

A relativistic radio component, which moves in a direction close to the sky plane, will increase in flux density when it decelerates. This effect is the basis for the qualitative model for GPS galaxies we present in this paper, which can explain their low-variability convex spectrum, their compact double or compact symmetric morphology, and the lack of GPS quasars at similar redshifts. Components are expelled from the nucleus at relativistic speeds at a large angle to the line of sight, and are decelerated (eg. by ram-pressure or entrainment of the external gas) before contributing to a mini-lobe. The young components are Doppler boosted in the direction of motion but appear fainter for the observer. The non-relativistic mini-lobes dominate the structure and are responsible for the low variability in flux density and the convex radio spectrum as well as the compact double angular morphology. Had the same source been orientated at a small angle to the line of sight, the young components would be boosted in the observer's direction resulting in a flat and variable radio spectrum at high frequencies. Hence the characteristic convex spectrum of a GPS source would not be seen. These sources at small angles to the line of sight are probably identified with quasars, and are not recognized as GPS sources, but are embedded in the large population of flat spectrum variable quasars and BL Lac objects. This leads to a deficiency in GPS/CSOs identified with quasars.Comment: 11 pages, LaTeX, accepted by A&A 26/Jan/199

WSRT 1.4 GHz Observations of the Hubble Deep Field

We present WSRT 1.38 GHz observations of the Hubble Deep Field (and flanking fields). 72 hours of data were combined to produce the WSRT's deepest image yet, achieving an r.m.s. noise level of 8 microJy per beam. We detect radio emission from galaxies both in the HDF and HFF which have not been previously detected by recent MERLIN or VLA studies of the field.Comment: 2 pages, 1 figure, to appear in "The Universe at Low Radio Frequencies", IAU Symposium 199. For colour figures, see http://www.nfra.nl/~mag/hdf_wsrt.htm

Calibration artefacts in radio interferometry. I. Ghost sources in WSRT data

This work investigates a particular class of artefacts, or ghost sources, in radio interferometric images. Earlier observations with (and simulations of) the Westerbork Synthesis Radio Telescope (WSRT) suggested that these were due to calibration with incomplete sky models. A theoretical framework is derived that validates this suggestion, and provides predictions of ghost formation in a two-source scenario. The predictions are found to accurately match the result of simulations, and qualitatively reproduce the ghosts previously seen in observational data. The theory also provides explanations for many previously puzzling features of these artefacts (regular geometry, PSF-like sidelobes, seeming independence on model flux), and shows that the observed phenomenon of flux suppression affecting unmodelled sources is due to the same mechanism. We demonstrate that this ghost formation mechanism is a fundamental feature of calibration, and exhibits a particularly strong and localized signature due to array redundancy. To some extent this mechanism will affect all observations (including those with non-redundant arrays), though in most cases the ghosts remain hidden below the noise or masked by other instrumental artefacts. The implications of such errors on future deep observations are discussed.Comment: 19 pages, 15 figures, submitted to MNRA

Response of thin-film SQUIDs to applied fields and vortex fields: Linear SQUIDs

In this paper we analyze the properties of a dc SQUID when the London penetration depth \lambda is larger than the superconducting film thickness d. We present equations that govern the static behavior for arbitrary values of \Lambda = \lambda^2/d relative to the linear dimensions of the SQUID. The SQUID's critical current I_c depends upon the effective flux \Phi, the magnetic flux through a contour surrounding the central hole plus a term proportional to the line integral of the current density around this contour. While it is well known that the SQUID inductance depends upon \Lambda, we show here that the focusing of magnetic flux from applied fields and vortex-generated fields into the central hole of the SQUID also depends upon \Lambda. We apply this formalism to the simplest case of a linear SQUID of width 2w, consisting of a coplanar pair of long superconducting strips of separation 2a, connected by two small Josephson junctions to a superconducting current-input lead at one end and by a superconducting lead at the other end. The central region of this SQUID shares many properties with a superconducting coplanar stripline. We calculate magnetic-field and current-density profiles, the inductance (including both geometric and kinetic inductances), magnetic moments, and the effective area as a function of \Lambda/w and a/w.Comment: 18 pages, 20 figures, revised for Phys. Rev. B, the main revisions being to denote the effective flux by \Phi rather than

A KOBE STRATEGY MAATRIX BASED UPON PROBABILISTIC REFERENCE POINTS: AN EXAMPLE USING A BIOMASS DYNAMIC ASSESSMENT MODEL

The main management objective of ICCAT is to maintain the populations of tuna and tuna-like fishes at levels which will permit the maximum sustainable catch. Scientific advice designed to meet this objective, in common with other tuna Regional Fisheries Management Organisations (tRFMO) scientific committees, is presented in the form of the Kobe II Strategy Matrix (K2SM). A decision table is given showing the time taken to achieve management objectives (e.g., stock recovery) for different levels of TAC or effort. However, substantial uncertainties still remain in assessments and therefore a key area of research is to show how uncertainty and improvements in information, consistent with the principles of the precautionary approach, can be incorporated into advice, so that for any level of uncertainty there is the same risk of depletion.JRC.G.4-Maritime affair

Tumor-infiltrating lymphocytes in the immunotherapy era

The clinical success of cancer immune checkpoint blockade (ICB) has refocused attention on tumor-infiltrating lymphocytes (TILs) across cancer types. The outcome of immune checkpoint inhibitor therapy in cancer patients has been linked to the quality and magnitude of T cell, NK cell, and more recently, B cell responses within the tumor microenvironment. State-of-the-art single-cell analysis of TIL gene expression profiles and clonality has revealed a remarkable degree of cellular heterogeneity and distinct patterns of immune activation and exhaustion. Many of these states are conserved across tumor types, in line with the broad responses observed clinically. Despite this homology, not all cancer types with similar TIL landscapes respond similarly to immunotherapy, highlighting the complexity of the underlying tumor-immune interactions. This observation is further confounded by the strong prognostic benefit of TILs observed for tumor types that have so far respond poorly to immunotherapy. Thus, while a holistic view of lymphocyte infiltration and dysfunction on a single-cell level is emerging, the search for response and prognostic biomarkers is just beginning. Within this review, we discuss recent advances in the understanding of TIL biology, their prognostic benefit, and their predictive value for therapy

Statistical Properties of Radio Emission from the Palomar Seyfert Galaxies

We have carried out an analysis of the radio and optical properties of a statistical sample of 45 Seyfert galaxies from the Palomar spectroscopic survey of nearby galaxies. We find that the space density of bright galaxies (-22 mag <= M_{B_T} <= -18 mag) showing Seyfert activity is (1.25 +/- 0.38) X 10^{-3} Mpc^{-3}, considerably higher than found in other Seyfert samples. Host galaxy types, radio spectra, and radio source sizes are uncorrelated with Seyfert type, as predicted by the unified schemes for active galaxies. Approximately half of the detected galaxies have flat or inverted radio spectra, more than expected based on previous samples. Surprisingly, Seyfert 1 galaxies are found to have somewhat stronger radio sources than Seyfert 2 galaxies at 6 and 20 cm, particularly among the galaxies with the weakest nuclear activity. We suggest that this difference can be accommodated in the unified schemes if a minimum level of Seyfert activity is required for a radio source to emerge from the vicinity of the active nucleus. Below this level, Seyfert radio sources might be suppressed by free-free absorption associated with the nuclear torus or a compact narrow-line region, thus accounting for both the weakness of the radio emission and the preponderance of flat spectra. Alternatively, the flat spectra and weak radio sources might indicate that the weak active nuclei are fed by advection-dominated accretion disks.Comment: 18 pages using emulateapj5, 13 embedded figures, accepted by Ap

A new sample of faint Gigahertz Peaked Spectrum radio sources

The Westerbork Northern Sky Survey (WENSS) has been used to select a sample of Gigahertz Peaked Spectrum (GPS) radio sources at flux densities one to two orders of magnitude lower than bright GPS sources investigated in earlier studies. Sources with inverted spectra at frequencies above 325 MHz have been observed with the WSRT at 1.4 and 5 GHz and with the VLA at 8.6 and 15 GHz to select genuine GPS sources. This has resulted in a sample of 47 GPS sources with peak frequencies ranging from ~500 MHz to >15 GHz, and peak flux densities ranging from ~40 to ~900 mJy. Counts of GPS sources in our sample as a function of flux density have been compared with counts of large scale sources from WENSS scaled to 2 GHz, the typical peak frequency of our GPS sources. The counts can be made similar if the number of large scale sources at 2 GHz is divided by 250, and their flux densities increase by a factor of 10. On the scenario that all GPS sources evolve into large scale radio sources, these results show that the lifetime of a typical GPS source is ~250 times shorter than a typical large scale radio source, and that the source luminosity must decrease by a factor of ~10 in evolving from GPS to large scale radio source. However, we note that the redshift distributions of GPS and large scale radio sources are different and that this hampers a direct and straightforward interpretation of the source counts. Further modeling of radio source evolution combined with cosmological evolution of the radio luminosity function for large sources is required.Comment: LaTeX, 15 pages, 8 figs. To be published in A&AS. For more info see http://www.ast.cam.ac.uk/~snelle