Investment Evaluation of New Technology: Integrating IT/IS Cost Management into Model

The inability of managers to determine the true costs of deploying Information Technology (IT)/Information System are considered attributable to a lack of knowledge and understanding of what constitutes an IT/IS related cost. In developing a deeper understanding of such costs and their respective taxonomies, the presented work in progress offers a conceptual model that is underpinned by a hypothesis. As a result, the proposed model can be used to support those firms seeking a rigorous cost evaluation

Peering from the outside in: viscoelastic properties of the extracellular matrix dictate spatial organization and apoptosis resistance in mammary epithelial cells

The compliance of the extracellular matrix (ECM) differs between tissues and is altered in tumors. We examined the consequence of modifying the viscoelastic properties of the ECM on mammary epithelial cell (MEC) morphogenesis and apoptosis regulation. Results showed that the elastic modulus of the ECM exerts a profound effect on MEC tissue organization and gene expression that correlates with changes in actin organization and apoptosis resistance. Altering the rigidity of the ECM directly influences integrin expression and additionally modifies integrin-induced gene expression in association with actin reorganization. These data suggest that the compliance of the ECM may cooperatively regulate cell behavior by altering integrin function. Studies are now underway to investigate the possibility that these effects are mediated via changes in integrin-actin cytoskeletal dynamics

The optimisation of a turbulent swirl nozzle using CFD

Swirl is imparted into free and impinging nozzle flows as well as jet flames to affect convective heat transfer, fluid mixing or flame stability. At the nozzle exit plane, the emerging flow strongly influences downstream flow development and so factors which impact upon the emitted flow are worthy of study. This paper presents preliminary CFD analyses into the effect of design parameters and operational settings on the emerging flow at the exit plane for a swirl nozzle (Remax~30,500). The research was conducted in the premanufacture stage to optimise the nozzle. Swirl is aerodynamically generated using multiple tangential ports located upstream of the exit plane and the streamwise flow is augmented with flow from two axial ports located at the nozzle base. Before reaching the exitplane, all flows pass through a contraction en route to a straight section of length (L). Factors studied in this paper include the angle of (inlet) tangential ports, the total length of the straight section (L), the ratio of axial-to-tangential inflows and the Reynolds number. Results show that larger tangential port angles and a shorter straight section help develop a modestly greate

Stability of the Blasius boundary layer over a heated plate in a temperature-dependent viscosity flow

We present complementary numerical and asymptotic studies of the flow over a heated, semi-infinite flat plate for a fluid with temperature-dependent viscosity. Liquid-type viscosities are found to entrain both the velocity and temperature profiles closer to the plate with increasing temperature sensitivity; gas-type viscosities are found to exhibit the reverse effect. A linear stability analysis is presented and we find that increasing the temperature dependence of the fluid (from gas- to liquid-type behavior) results in an increased critical Reynolds number to a point of maximum stability. Using an energy-balance approach, we determine that this behavior is primarily driven by the inviscid instability of the modified steady flow, rather than being a result of modified viscous instability effects. Application and extension of the results are considered in the context of chemical vapor deposition

URBAN HEAT ISLAND MICRO-MAPPING VIA 3D CITY MODEL

Urban Heat Island (UHI) phenomenon has been a topic of intense study over the past several years. However, to visualise UHI model is still an issue. Common visualisation of UHI by using digital thematic maps shows that it is hard to perceive its impacts especially in a sophisticated micro-area such as in urbanized cities. Moreover, different building façade’s material gives different UHI value. Therefore, there is a need in computing and visualising this phenomenon in three-dimensional (3D) perspectives. Recently, the development of 3D city modelling shows the potential of solving these gaps. This can be seen from the characteristics of 3D city models that are suitable in representing micro-areas (complex cities) for UHI studies. Based on this issue, this research aims to produce a 3D UHI model by using 3D city models as a tool for efficient and sustainable building design. The main objective is to produce a new approach in visualising UHI in 3D perspectives by instigating 3D city models. Thus, the UHI effect could be predicted precisely by calculating the building façades value. This research explores the 3D shadow analysis, 3D solar radiation and 3D orientation analysis in UHI modelling via 3D city models. From the analyses, the results show that the 3D city models are capable in presenting the solar radiation value for each building façade. Furthermore, this approach can be used to simulate future UHI analysis-prediction and advantageous for pre-development planning

Cisplatin-induced posterior reversible encephalopathy syndrome and successful re-treatment in a patient with non-seminomatous germ cell tumor: a case report

UNLABELLED: Introduction: Cisplatin is a platinum compound that has revolutionized the treatment of various solid organ tumors. Cisplatin is associated with a variety of side effects and has recently been indicted in the development of posterior reversible encephalopathy syndrome. Posterior reversible encephalopathy syndrome is a potentially reversible condition, with the mainstay of therapy being correction of the underlying cause and withdrawal of the offending drug. However, there are no clear guidelines regarding the possibility of subsequent re-treatment with the causative agent.CASE PRESENTATION: A 23-year-old Asian man presented to our Emergency Department with a four-month history of concomitant abdominal pain and backache and a two-week history of left-sided leg swelling. Diagnostic investigations revealed bilateral pulmonary embolism, extensive deep venous thrombosis and widespread lung and liver metastatic deposits with abdomino-pelvic lymphadenopathy. His biopsy and tumor markers were consistent with non-seminomatous germ cell tumor and he was subsequently started on an initial cycle of cisplatin and etoposide chemotherapy. On the second day of treatment he developed posterior reversible encephalopathy syndrome clinically and radiologically. Cisplatin was stopped for the next two days while etoposide was continued, resulting in complete resolution of his symptoms. He was re-challenged with cisplatin on day five of chemotherapy because a platin-based chemotherapy regimen was his only hope of potential cure. He tolerated it well, with no recurrence of his neurological symptoms and the remainder of his in-patient stay remained uneventful. He was discharged on day eight. He has since then completed treatment and is currently in remission.CONCLUSIONS: The occurrence of posterior reversible encephalopathy syndrome after cisplatin use has been well reported in the literature. We strongly believe that our patient also developed posterior reversible encephalopathy syndrome secondary to cisplatin. The uniqueness of our patient\u27s case lies in the successful re-treatment of our patient with the offending drug. To the best of our knowledge, this is the first instance where a patient was successfully re-treated with cisplatin after having developed posterior reversible encephalopathy syndrome as a result of cisplatin use. The excellent response to re-treatment without recurrence of neurological symptoms in our patient\u27s case provides insight into re-treatment as an option in scenarios where treatment options are limited

Edoxaban: an update on the new oral direct factor Xa inhibitor.

Edoxaban is a once-daily oral anticoagulant that rapidly and selectively inhibits factor Xa in a concentration-dependent manner. This review describes the extensive clinical development program of edoxaban, including phase III studies in patients with non-valvular atrial fibrillation (NVAF) and symptomatic venous thromboembolism (VTE). The ENGAGE AF-TIMI 48 study (N = 21,105; mean CHADS2 score 2.8) compared edoxaban 60 mg once daily (high-dose regimen) and edoxaban 30 mg once daily (low-dose regimen) with dose-adjusted warfarin [international normalized ratio (INR) 2.0-3.0] and found that both regimens were non-inferior to warfarin in the prevention of stroke and systemic embolism in patients with NVAF. Both edoxaban regimens also provided significant reductions in the risk of hemorrhagic stroke, cardiovascular mortality, major bleeding and intracranial bleeding. The Hokusai-VTE study (N = 8,292) in patients with symptomatic VTE had a flexible treatment duration of 3-12 months and found that following initial heparin, edoxaban 60 mg once daily was non-inferior to dose-adjusted warfarin (INR 2.0-3.0) for the prevention of recurrent VTE, and also had a significantly lower risk of bleeding events. Both studies randomized patients at moderate-to-high risk of thromboembolic events and were further designed to simulate routine clinical practice as much as possible, with edoxaban dose reduction (halving dose) at randomisation or during the study if required, a frequently monitored and well-controlled warfarin group, a well-monitored transition period at study end and a flexible treatment duration in Hokusai-VTE. Given the phase III results obtained, once-daily edoxaban may soon be a key addition to the range of antithrombotic treatment options

Effects of a Standardized Phenolic-Enriched Maple Syrup Extract on β-Amyloid Aggregation, Neuroinflammation in Microglial and Neuronal Cells, and β-Amyloid Induced Neurotoxicity in \u3cem\u3eCaenorhabditis elegans\u3c/em\u3e

Published data supports the neuroprotective effects of several phenolic-containing natural products, including certain fruit, berries, spices, nuts, green tea, and olive oil. However, limited data are available for phenolic-containing plant-derived natural sweeteners including maple syrup. Herein, we investigated the neuroprotective effects of a chemically standardized phenolic-enriched maple syrup extract (MSX) using a combination of biophysical, in vitro, and in vivo studies. Based on biophysical data (Thioflavin T assay, transmission electron microscopy, circular dichroism, dynamic light scattering, and zeta potential), MSX reduced amyloid β1−42 peptide (Aβ1−42) fibrillation in a concentration-dependent manner (50–500 μg/mL) with similar effects as the neuroprotective polyphenol, resveratrol, at its highest test concentration (63.5 % at 500 μg/mL vs. 77.3 % at 50 μg/mL, respectively). MSX (100 μg/mL) decreased H2O2-induced oxidative stress (16.1 % decrease in ROS levels compared to control), and down-regulated the production of lipopolysaccharide (LPS)-stimulated inflammatory markers (22.1, 19.9, 74.8, and 87.6 % decrease in NOS, IL-6, PGE2, and TNFα levels, respectively, compared to control) in murine BV-2 microglial cells. Moreover, in a non-contact co-culture cell model, differentiated human SH-SY5Y neuronal cells were exposed to conditioned media from BV-2 cells treated with MSX (100 μg/mL) and LPS or LPS alone. MSX-BV-2 media increased SH-SY5Y cell viability by 13.8 % compared to media collected from LPS-BV-2 treated cells. Also, MSX (10 μg/mL) showed protective effects against Aβ1−42 induced neurotoxicity and paralysis in Caenorhabditis elegans in vivo. These data support the potential neuroprotective effects of MSX warranting further studies on this natural product

Effects of Dibutyryl Cyclic-AMP on Survival and Neuronal Differentiation of Neural Stem/Progenitor Cells Transplanted into Spinal Cord Injured Rats

Neural stem/progenitor cells (NSPCs) have great potential as a cell replacement therapy for spinal cord injury. However, poor control over transplant cell differentiation and survival remain major obstacles. In this study, we asked whether dibutyryl cyclic-AMP (dbcAMP), which was shown to induce up to 85% in vitro differentiation of NSPCs into neurons would enhance survival of transplanted NSPCs through prolonged exposure either in vitro or in vivo through the controlled release of dbcAMP encapsulated within poly(lactic-co-glycolic acid) (PLGA) microspheres and embedded within chitosan guidance channels. NSPCs, seeded in fibrin scaffolds within the channels, differentiated in vitro to betaIII-tubulin positive neurons by immunostaining and mRNA expression, in response to dbcAMP released from PLGA microspheres. After transplantation in spinal cord injured rats, the survival and differentiation of NSPCs was evaluated. Untreated NSPCs, NSPCs transplanted with dbcAMP-releasing microspheres, and NSPCs pre-differentiated with dbcAMP for 4 days in vitro were transplanted after rat spinal cord transection and assessed 2 and 6 weeks later. Interestingly, NSPC survival was highest in the dbcAMP pre-treated group, having approximately 80% survival at both time points, which is remarkable given that stem cell transplantation often results in less than 1% survival at similar times. Importantly, dbcAMP pre-treatment also resulted in the greatest number of in vivo NSPCs differentiated into neurons (37±4%), followed by dbcAMP-microsphere treated NSPCs (27±14%) and untreated NSPCs (15±7%). The reverse trend was observed for NSPC-derived oligodendrocytes and astrocytes, with these populations being highest in untreated NSPCs. This combination strategy of stem cell-loaded chitosan channels implanted in a fully transected spinal cord resulted in extensive axonal regeneration into the injury site, with improved functional recovery after 6 weeks in animals implanted with pre-differentiated stem cells in chitosan channels

Becoming and being academic women: Perspectives from the Maldives

Abstract: This exploratory study aimed at understanding the role of women teaching in a university in the Maldives is a first of its kind. The many studies of academic women in Western countries guided the 20 semi-structured interviews. The data were thematically analysed with the assistance of NVivo. Becoming an academic appeared to be an independent decision for the majority of women. There was little parental influence. A common theme was the women perceived that, in general, they worked harder than men. They perceived little or no work differences, despite the observation that men filled senior positions at the university. Although work/ life balance was difficult to maintain, a striking finding was that the majority of the women were quite satisfied. From the point of view of most of the women interviewed, gender was little or not an issue, in that there was no indication of frustration or anger amongst the women interviewed. Several issues are identified for future research. Mizna Mohamed's research focuses on evaluation of coral reefs. Mizna currently teaches natural resource management and has an interest in traditional ecological knowledge and role of women in management of natural environments. Naashia Mohamed teaches courses in applied linguistics and research methods and was originally a teacher. Her research interests include teacher cognition, language education and bilingualism. Badhoora Naseer teaches courses in education and research methods. Her research interests include special education and inclusive education. Aminath Zahir serves as the head of the Dhivehi Department and teaches history, grammar and research methods. Her fields of research include linguistics and grammar. Aminath Nasheeda teaches English and study skills. Her research interest lies in the field of English, language specifically for second-language learners. PUBLIC INTEREST STATEMENT Higher education is relatively new in the Maldives. There is one university. This is the first study of the role of academic women in the Maldives and previous studies guided the research. The 20 interviews of 10 senior and 10 junior females were carried out in Dhivehi or English by five young female researchers, translated by them and then analysed with the assistance of NVivo to find the main themes. Becoming an academic appeared to be an independent decision for the majority of women with little parental influence. The women perceived that they worked harder than men. They perceived little or no work differences though men filled senior positions. Work/life balance was difficult to maintain, but the majority of the women were quite satisfied. Amongst these women, gender was not an issue, in that there was no indication of frustration or anger amongst the women interviewed