Integrated nonlinear structural simulation of composite buildings in fire

The collapse of several tall composite buildings over the last two decades has shown that the performance of tall, composite and complex buildings in fire is a necessary design consideration that ought to go beyond simple code compliance. To this end, several advancements in the field of numerical simulation of both the fire and the thermomechanical response of structures have been made. In isolation, the practical benefit of these advancements is limited, and their true potential is only unlocked when the results of those numerical simulations are integrated. This paper starts by showcasing recent developments in the thermal and thermomechanical analysis of structures using OpenSees. Integration of these developments into a unified simulation environment combining fire simulation, heat transfer, and mechanical analysis is then introduced. Finally, a demonstration example based on the large compartment Cardington test is used to showcase the necessity and efficiency of the developed simulation environment for thermomechanical simulation of composite structures in fire

Relationship between Peak Inspiratory Flow and Patient and Disease Characteristics in Individuals with COPD-A Systematic Scoping Review

Optimal delivery of medication via dry powder inhalers, the most commonly prescribed inhaler type, is dependent on a patient achieving a minimum level of inspiratory flow during inhalation. However, measurement of peak inspiratory flow (PIF) against the simulated resistance of a dry powder inhaler is not frequently performed in clinical practice due to time or equipment limitations. Therefore, defining which patient characteristics are associated with lower PIF is critically important to help clinicians optimize their inhaler choice through a more personalized approach to prescribing. The objective of this scoping review was to systematically evaluate patient and disease characteristics determining PIF in patients with chronic obstructive pulmonary disease (COPD). Medline, Cochrane and Embase databases were systematically searched for relevant studies on PIF in patients with COPD published in English between January 2000 and May 2021. The quality of evidence was assessed using a modified Grading of Recommendations Assessment, Development and Evaluation checklist. Of 3382 citations retrieved, 35 publications were included in the review (nine scored as high quality, 13 as moderate, nine as low, and four as very low). Factors correlating with PIF in >70% of papers included both patient characteristics (lower PIF correlated with increased age, female gender, shorter height, decreased handgrip and inspiratory muscle strength, and certain comorbidities) and disease characteristics (lower PIF correlated with markers of lung hyperinflation, lower peak expiratory flow [PEF] and increased disease severity). Other factors correlating with adequate/optimal or improved PIF included education/counseling and exercise/inspiratory muscle training; impaired physical function and errors in inhalation technique/non-adherence were associated with low/suboptimal PIF. In conclusion, clinicians should measure PIF against the simulated resistance of a particular device wherever possible. However, as this often cannot be done due to lack of resources or time, the patient and disease characteristics that influence PIF, as identified in this review, can help clinicians to choose the most appropriate inhaler type for their patients

Quantum Storage of Photonic Entanglement in a Crystal

Entanglement is the fundamental characteristic of quantum physics. Large experimental efforts are devoted to harness entanglement between various physical systems. In particular, entanglement between light and material systems is interesting due to their prospective roles as "flying" and stationary qubits in future quantum information technologies, such as quantum repeaters and quantum networks. Here we report the first demonstration of entanglement between a photon at telecommunication wavelength and a single collective atomic excitation stored in a crystal. One photon from an energy-time entangled pair is mapped onto a crystal and then released into a well-defined spatial mode after a predetermined storage time. The other photon is at telecommunication wavelength and is sent directly through a 50 m fiber link to an analyzer. Successful transfer of entanglement to the crystal and back is proven by a violation of the Clauser-Horne-Shimony-Holt (CHSH) inequality by almost three standard deviations (S=2.64+/-0.23). These results represent an important step towards quantum communication technologies based on solid-state devices. In particular, our resources pave the way for building efficient multiplexed quantum repeaters for long-distance quantum networks.Comment: 5 pages, 3 figures + supplementary information; fixed typo in ref. [36

Momentum distributions in ^3He-^4He liquid mixtures

We present variational calculations of the one-body density matrices and momentum distributions for ^3He-^4He mixtures in the zero temperature limit, in the framework of the correlated basis functions theory. The ground-state wave function contains two- and three-body correlations and the matrix elements are computed by (Fermi)Hypernetted Chain techniques. The dependence on the ^3He concentration (x_3) of the ^4He condensate fraction $(n_0^{(4)})$ and of the ^3He pole strength (Z_F) is studied along the P=0 isobar. At low ^3He concentration, the computed ^4He condensate fraction is not significantly affected by the ^3He statistics. Despite of the low x_3 values, Z_F is found to be quite smaller than that of the corresponding pure ^3He because of the strong ^3He-^4He correlations and of the overall, large total density \rho. A small increase of $n_0^{(4)}$ along x_3 is found, which is mainly due to the decrease of \rho respect to the pure ^4He phase.Comment: 23 pages, 7 postscript figures, Revte

Dynamical instabilities of a resonator driven by a superconducting single-electron transistor

We investigate the dynamical instabilities of a resonator coupled to a superconducting single-electron transistor (SSET) tuned to the Josephson quasiparticle (JQP) resonance. Starting from the quantum master equation of the system, we use a standard semiclassical approximation to derive a closed set of mean field equations which describe the average dynamics of the resonator and SSET charge. Using amplitude and phase coordinates for the resonator and assuming that the amplitude changes much more slowly than the phase, we explore the instabilities which arise in the resonator dynamics as a function of coupling to the SSET, detuning from the JQP resonance and the resonator frequency. We find that the locations (in parameter space) and sizes of the limit cycle states predicted by the mean field equations agree well with numerical solutions of the full master equation for sufficiently weak SSET-resonator coupling. The mean field equations also give a good qualitative description of the set of dynamical transitions in the resonator state that occur as the coupling is progressively increased.Comment: 23 pages, 6 Figures, Accepted for NJ

Highly multimode memory in a crystal

We experimentally demonstrate the storage of 1060 temporal modes onto a thulium-doped crystal using an atomic frequency comb (AFC). The comb covers 0.93 GHz defining the storage bandwidth. As compared to previous AFC preparation methods (pulse sequences i.e. amplitude modulation), we only use frequency modulation to produce the desired optical pumping spectrum. To ensure an accurate spectrally selective optical pumping, the frequency modulated laser is self-locked on the atomic comb. Our approach is general and should be applicable to a wide range of rare-earth doped material in the context of multimode quantum memory

Post-Transplant Outcomes in High-Risk Compared with Non-High-Risk Multiple Myeloma: A CIBMTR Analysis.

Conventional cytogenetics and interphase fluorescence in situ hybridization (FISH) identify high-risk multiple myeloma (HRM) populations characterized by poor outcomes. We analyzed these differences among HRM versus non-HRM populations after upfront autologous hematopoietic cell transplantation (autoHCT). Between 2008 and 2012, 715 patients with multiple myeloma identified by FISH and/or cytogenetic data with upfront autoHCT were identified in the Center for International Blood and Marrow Transplant Research database. HRM was defined as del17p, t(4;14), t(14;16), hypodiploidy (-Y) or chromosome 1 p and 1q abnormalities; all others were non-HRM. Among 125 HRM patients (17.5%), induction with bortezomib and immunomodulatory agents (imids) was higher compared with non-HRM (56% versus 43%, P \u3c .001) with similar pretransplant complete response (CR) rates (14% versus 16%, P .1). At day 100 post-transplant, at least a very good partial response was 59% in HRM and 61% in non-HRM (P = .6). More HRM patients received post-transplant therapy with bortezomib and imids (26% versus 12%, P = .004). Three-year post-transplant progression-free (PFS) and overall survival (OS) rates in HRM versus non-HRM were 37% versus 49% (P \u3c .001) and 72% versus 85% (P \u3c .001), respectively. At 3 years, PFS for HRM patients with and without post-transplant therapy was 46% (95% confidence interval [CI], 33 to 59) versus 14% (95% CI, 4 to 29) and in non-HRM patients with and without post-transplant therapy 55% (95% CI, 49 to 62) versus 39% (95% CI, 32 to 47); rates of OS for HRM patients with and without post-transplant therapy were 81% (95% CI, 70 to 90) versus 48% (95% CI, 30 to 65) compared with 88% (95% CI, 84 to 92) and 79% (95% CI, 73 to 85) in non-HRM patients with and without post-transplant therapy, respectively. Among patients receiving post-transplant therapy, there was no difference in OS between HRM and non-HRM (P = .08). In addition to HRM, higher stage, less than a CR pretransplant, lack of post-transplant therapy, and African American race were associated with worse OS. In conclusion, we show HRM patients achieve similar day 100 post-transplant responses compared with non-HRM patients, but these responses are not sustained. Post-transplant therapy appeared to improve the poor outcomes of HRM

Galactic rotation curves inspired by a noncommutative-geometry background

This paper discusses the observed at rotation curves of galaxies in the context of noncommutative geometry. The energy density of such a geometry is diffused throughout a region due to the uncertainty encoded in the coordinate commutator. This intrinsic property appears to be sufficient for producing stable circular orbits, as well as attractive gravity, without the need for dark matter.Comment: 12 pages, 3 figures. Published in Gen.Rel.Grav. 44 (2012) 905-91

Islamic labeled firms: Revisiting Dow Jones measure of compliance

Billions of dollars, across 131 countries, are invested in Islamic law‐compliant funds that are often promoted as consistent with the spirit and overall objectives of Islam (Maqasid Al‐Sharia), thereby indicating they are more socially responsible, less risky, and less prone to failure. The empirical results of this study indicate that Shariah‐compliant firms identified by the Dow Jones do not have higher corporate social responsibility (CSR) scores, lower risk, or lower likelihood of failure than non‐compliant firms. We address endogeneity using the instrumental variable (IV) approach and selection bias using propensity score matching (PSM). Our results are similar when using the Dow Jones Islamic Market World, the Financial Times Stock Exchange Islamic Index, and the Hong Kong and Shanghai Banking Corporation indices and when using CSR scores provided by multiple databases. We create an index to measure compliance with Islamic law that overcomes several flaws in the binary measures currently employed in the industry. This index can help Shariah‐compliant funds to fulfill their promise by constructing portfolios that are both compliant with Islamic rulings and consistent with the spirit and objectives of Islam in being more socially responsible, less risky, and less prone to failure