Winding Number in String Field Theory

Motivated by the similarity between cubic string field theory (CSFT) and the Chern-Simons theory in three dimensions, we study the possibility of interpreting N=(\pi^2/3)\int(U Q_B U^{-1})^3 as a kind of winding number in CSFT taking quantized values. In particular, we focus on the expression of N as the integration of a BRST-exact quantity, N=\int Q_B A, which vanishes identically in naive treatments. For realizing non-trivial N, we need a regularization for divergences from the zero eigenvalue of the operator K in the KBc algebra. This regularization must at same time violate the BRST-exactness of the integrand of N. By adopting the regularization of shifting K by a positive infinitesimal, we obtain the desired value N[(U_tv)^{\pm 1}]=\mp 1 for U_tv corresponding to the tachyon vacuum. However, we find that N[(U_tv)^{\pm 2}] differs from \mp 2, the value expected from the additive law of N. This result may be understood from the fact that \Psi=U Q_B U^{-1} with U=(U_tv)^{\pm 2} does not satisfy the CSFT EOM in the strong sense and hence is not truly a pure-gauge in our regularization.Comment: 20 pages, no figures; v2: references added, minor change

Influence of oxidative stress and effect of topical application of α-tocopherol on wound healing in a diabetic animal model

Background: Understanding mechanisms involved in development of diabetes mellitus-associated ulcers is vital to pioneering alternative care approaches. This study aimed to establish effects of oxidative stress (OS) and α-tocopherol’s effect on diabetic wound healing.Methods: Using two animal experimental designs surgical wounds were created in 4 groups of 9-week-old diabetic and non-diabetic rats. OS was induced through antioxidant enzyme inhibition. In experiment-1 wounds were allowed to heal. In experiment-2 varying concentrations of topical α-tocopherol and/or the ointment-base were administered to diabetic animal wounds. Intermittent comparison of wound morphology, histology and local and systemic OS parameters was done.Results: Irrespective of diabetic state, OS was associated with delayed wound size reduction and poor granulation-tissue collagen deposition. Delayed and subdued local glutathione peroxidase activity in response to wounding and OS induction was more pronounced in diabetic animals. Diabetic animals also showed higher serum malondialdehyde levels regardless of OS induction. Topical application of α-tocopherol was associated with denser wound granulation tissue collagen deposition but could not affect serum malondialdehyde levels.Conclusions: OS interferes with wound healing especially collagen deposition and the effect is more pronounced in a diabetic state. Topical α-tocopherol can improve collagen deposition in diabetic wounds but cannot counteract systemic OS, therefore combining systemic and local antioxidant supplementation has potential for use in DFU care

FUNGAL BIODEGRADATION OF BISPHENOL A AND BENZOPHENONE

Joint Research on Environmental Science and Technology for the Eart

The CR chondrite clan

The (1) CR chondrites, (2) LEW 85332,(3) Acfer 182,(4) ALH 85085-like chondrites, and (5) Bencubbin-like chondritic breccias are five kinds of chondritic groups which have dramatically different petrographic characteristics, but have mineralogical, bulk chemical, and oxygen and nitrogen isotopic similarities that indicate they are closely related. They are all considered to be members of what we term the CR chondrite clan. Distinguishing characteristics of CR clan chondrites include : (a) reduced, Mg-rich mafic silicates, (b) hydrous matrix and/or dark inclusions (except for Bencubbin-like chondrites), (c) high modal abundances of FeNi metal, (d) FeNi metal having a solar Ni : Co ratio, (e) solar (CI) abundances of refractory and moderately volatile lithophiles, and highly depleted abundances of volatile lithophiles, (f) similar oxygen isotopic compositions of whole rocks, chondrules and matrices, which are on or near the CR mixing line, and (g) anomalously high ^N abundances. CR clan chondrites must have formed in the same local region of the nebula, from closely related reservoirs of materials. The coexistence of anhydrous chondrules with hydrous matrix (and dark inclusions) in the LEW 85332,Acfer 182,and ALH 85085-like chondrites, as well as the widely differing degrees of hydration within and between chondritic samples, implies that hydration of the components was not variable in a single locality, but took place at a variety of locales prior to final lithification of the CR clan chondrites

Protein signatures of centenarians and their offspring suggest centenarians age slower than other humans

Using samples from the New England Centenarian Study (NECS), we sought to characterize the serum proteome of 77 centenarians, 82 centenarians\u27 offspring, and 65 age-matched controls of the offspring (mean ages: 105, 80, and 79 years). We identified 1312 proteins that significantly differ between centenarians and their offspring and controls (FDR \u3c 1%), and two different protein signatures that predict longer survival in centenarians and in younger people. By comparing the centenarian signature with 2 independent proteomic studies of aging, we replicated the association of 484 proteins of aging and we identified two serum protein signatures that are specific of extreme old age. The data suggest that centenarians acquire similar aging signatures as seen in younger cohorts that have short survival periods, suggesting that they do not escape normal aging markers, but rather acquire them much later than usual. For example, centenarian signatures are significantly enriched for senescence-associated secretory phenotypes, consistent with those seen with younger aged individuals, and from this finding, we provide a new list of serum proteins that can be used to measure cellular senescence. Protein co-expression network analysis suggests that a small number of biological drivers may regulate aging and extreme longevity, and that changes in gene regulation may be important to reach extreme old age. This centenarian study thus provides additional signatures that can be used to measure aging and provides specific circulating biomarkers of healthy aging and longevity, suggesting potential mechanisms that could help prolong health and support longevity

Variants of the serotonin transporter gene and NEO-PI-R Neuroticism: No association in the BLSA and SardiNIA samples

The polymorphism in the serotonin transporter gene promoter region (5-HTTLPR) is by far the most studied variant hypothesized to influence Neuroticism-related personality traits. The results of previous studies have been mixed and appear moderated by the personality questionnaire used. Studies that used the TCI to assess Harm Avoidance or the EPQ to assess Neuroticism have found no association with the 5-HTTLPR. However, studies that used the NEO-PI-R or related instruments (NEO-PI, NEO-FFI) to measure Neuroticism have found some evidence of association. This study examines the association of variants in the serotonin transporter gene in a sample from a genetically isolated population within Sardinia (Italy) that is several times larger than previous samples that used the NEO-PI-R (N = 3,913). The association was also tested in a sample (N = 548) from the Baltimore Longitudinal Study of Aging (BLSA), in which repeated NEO-PI-R assessments were obtained. In the SardiNIA sample, we found no significant association of the 5-HTTLPR genotypes with Neuroticism or its facets (Anxiety, Angry-Hostility, Depression, Self-Consciousness, Impulsiveness, and Vulnerability). In the BLSA sample, we found lower scores on Neuroticism traits for the heterozygous group, which is inconsistent with previous studies. We also examined eight SNPs in the SardiNIA (N = 3,972) and nine SNPs in the BLSA (N = 1,182) that map within or near the serotonin transporter gene (SLC6A4), and found no association. Along with other large studies that used different phenotypic measures and found no association, this study substantially increases the evidence against a link between 5-HTT variants and Neuroticism-related traits. © 2009 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/64573/1/30932_ftp.pd

Biological, clinical and population relevance of 95 loci for blood lipids.

Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with plasma lipids in >100,000 individuals of European ancestry. Here we report 95 significantly associated loci (P < 5 x 10(-8)), with 59 showing genome-wide significant association with lipid traits for the first time. The newly reported associations include single nucleotide polymorphisms (SNPs) near known lipid regulators (for example, CYP7A1, NPC1L1 and SCARB1) as well as in scores of loci not previously implicated in lipoprotein metabolism. The 95 loci contribute not only to normal variation in lipid traits but also to extreme lipid phenotypes and have an impact on lipid traits in three non-European populations (East Asians, South Asians and African Americans). Our results identify several novel loci associated with plasma lipids that are also associated with CAD. Finally, we validated three of the novel genes-GALNT2, PPP1R3B and TTC39B-with experiments in mouse models. Taken together, our findings provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD