143 research outputs found
Experimental Evaluation of Geopolymer Concrete Strength Using Sea Sand and Sea Water in Mixture
This paper presents the experimental strength evaluation of geopolymer concrete and ordinary concrete using sea sand and seawater in the mixture. A series of 30 cubic samples with a 150 mm side length and 12 rectangular specimens with a dimension of 100 × 100 × 400 mm (width × thickness × length) were cast and tested in this study. Specimens were divided equally into two groups. The first group of specimens was cast using geopolymer as the main binder (GPC), while the second group of samples was made using ordinary Portland Cement (OPC). While the compression tests were performed for specimens in two groups at the ages of 3, 7, 28, 60, and 120 days, the tensile tests were only performed for specimens at 7 and 28 days. The testing results revealed that the compression strength of GPC specimens using sea sand and seawater was significantly higher than that of OPC samples using the same type of salted sand and water. Besides, the use of sea sand and seawater for replacing river sand and fresh water in the production of GPC is feasible in terms of compressive strength since GPC produces a higher compressive strength than that of conventional concrete. Doi: 10.28991/CEJ-2022-08-08-03 Full Text: PD
Computational chemo-thermo-mechanical coupling phase-field model for complex fracture induced by early-age shrinkage and hydration heat in cement-based materials
In this paper, we present a new multi-physics computational framework that enables us to capture and investigate complex fracture behavior in cement-based materials at early-age. The present model consists of coupling the most important chemo-thermo-mechanical processes to describe temperature evolution, variation of hydration degree, and mechanical behavior. The changes of material properties are expressed as a function of the hydration degree, to capture the age effects. Fracture analysis of these processes are then accommodated by a versatile phase field model in the framework of smeared crack models, addressing the influence of cracks on hydration and thermal transfer. We additionally describe a stable and robust numerical algorithm, which aims to solve coupled problems by using a staggered scheme. The developed approach is applied to study the fracture phenomena at both macroscopic and mesoscopic scales, in which all microstructural heterogeneities of sand and cement matrix are explicitly accounted. Nucleation, initiation, and propagation of complex crack network are simulated in an efficient way demonstrating the potential of the proposed approach to assess the early-age defects in concrete structures and materials
Role of interfacial transition zone in phase field modeling of fracture in layered heterogeneous structures
Mechanical behavior of layered materials and structures greatly depends on the mechanical behavior of interfaces. In the past decades, the failure in such layered media has been studied by many researchers due to their critical role in the mechanics and physics of solids. This study aims at investigating crack-interface interaction in two-dimensional (2-D) and three-dimensional (3-D) layered media by a phase field model. Our objectives are fourfold: (a) to better understand fracture behavior in layered heterogeneous systems under quasi-static load; (b) to introduce a new methodology for better describing interfaces by a regularized interfacial transition zone in the context of varia-tional phase field approach, exploring its important role; (c) to show the accuracy , performance and applicability of the present model in modeling material failure at the interfaces in both 2-D and 3-D bodies; and (d) to quantitatively validate computed crack path with respect to experimental data. Phase field models with both perfectly and cohesive bonded interfaces are thus derived. A regularized interfacial transition zone is introduced to capture characteristics of material mismatch at the interfaces. Numerical examples for 2-D and 3-D layered systems with experimental validation provide fundamentals of fracture behavior in layered structures. The obtained results shed light on the behavior of crack paths, which are drastically affected by the elastic modulus mismatch between two layers and interface types, and reveal the important role of the proposed interfacial transition zone in phase field modeling of crack interface interactions
Development and Characterization of Curcumin-Silver Nanoparticles as a Promising Formulation to Test on Human Pterygium-Derived Keratinocytes
Pterygium is a progressive disease of the human eye arising from sub-conjunctival tissue and extending onto the cornea. Due to its invasive growth, pterygium can reach the pupil compromising visual function. Currently available medical treatments have limited success in suppressing efficiently the disease. Previous studies have demonstrated that curcumin, polyphenol isolated from the rhizome of Curcuma longa, induces apoptosis of human pterygium fibroblasts in a dose- and time-dependent manner showing promising activity in the treatment of this ophthalmic disease. However, this molecule is not very soluble in water in either neutral or acidic pH and is only slightly more soluble in alkaline conditions, while its dissolving in organic solvents drastically reduces its potential use for biomedical applications. A nanoformulation of curcumin stabilized silver nanoparticles (Cur-AgNPs) seems an effective strategy to increase the bioavailability of curcumin without inducing toxic effects. In fact, silver nitrates have been used safely for the treatment of many ophthalmic conditions and diseases for a long time and the concentration of AgNPs in this formulation is quite low. The synthesis of this new compound was achieved through a modified Bettini's method adapted to improve the quality of the product intended for human use. Indeed, the pH of the reaction was changed to 9, the temperature of the reaction was increased from 90 °C to 100 °C and after the synthesis the Cur-AgNPs were dispersed in Borax buffer using a dialysis step to improve the biocompatibility of the formulation. This new compound will be able to deliver both components (curcumin and silver) at the same time to the affected tissue, representing an alternative and a more sophisticated strategy for the treatment of human pterygium. Further in vitro and in vivo assays will be required to validate this formulation
When can we reconstruct the ancestral state? Beyond Brownian motion
Reconstructing the ancestral state of a group of species helps answer many
important questions in evolutionary biology. Therefore, it is crucial to
understand when we can estimate the ancestral state accurately. Previous works
provide a necessary and sufficient condition, called the big bang condition,
for the existence of an accurate reconstruction method under discrete trait
evolution models and the Brownian motion model. In this paper, we extend this
result to a wide range of continuous trait evolution models. In particular, we
consider a general setting where continuous traits evolve along the tree
according to stochastic processes that satisfy some regularity conditions. We
verify these conditions for popular continuous trait evolution models including
Ornstein-Uhlenbeck, reflected Brownian Motion, and Cox-Ingersoll-Ross
LEGO-inspired drug design: Discovery of novel fungal Plasma membrane H+-ATPase (Pma1) inhibitors from small molecule libraries: An introduction of HFSA-SBS_DOS-RD strategy in drug discovery.
Perturbing dissimilar biomolecular targets from natural product scaffolds and focused chemical decoration.
The CIPAZ study protocol: an open label randomised controlled trial of azithromycin versus ciprofloxacin for the treatment of children hospitalised with dysentery in Ho Chi Minh City, Vietnam
Background: Diarrhoeal disease remains a common cause of illness and death in children <5 years of age. Faecal-oral infection by Shigella spp. causing bacillary dysentery is a leading cause of moderate-to-severe diarrhoea, particularly in low and middle-income countries. In Southeast Asia, S. sonnei predominates and infections are frequently resistant to first-line treatment with the fluoroquinolone, ciprofloxacin. While resistance to all antimicrobials is increasing, there may be theoretical and clinical benefits to prioritizing treatment of bacillary dysentery with the azalide, azithromycin. In this study we aim to measure the efficacy of treatment with azithromycin compared with ciprofloxacin, the current standard of care, for the treatment of children with bacillary dysentery.
Methods and analysis: We will perform a multicentre, open-label, randomized controlled trial of two therapeutic options for the antimicrobial treatment of children hospitalised with dysentery. Children (6–60 months of age) presenting with symptoms and signs of dysentery at Children’s Hospital 2 in Ho Chi Minh City will be randomised (1:1) to treatment with either oral ciprofloxacin (15mg/kg/twice daily for 3 days, standard-of-care) or oral azithromycin (10mg/kg/daily for 3 days). The primary endpoint will be the proportion of treatment failure (defined by clinical and microbiological parameters) by day 28 (+3 days) and will be compared between study arms by logistic regression modelling using treatment allocation as the main variable.
Ethics and dissemination: The study protocol (version 1.2 dated 27th December 2018) has been approved by the Oxford Tropical Research Ethics Committee (47–18) and the ethical review boards of Children's Hospital 2 (1341/NĐ2-CĐT). The study has also been approved by the Vietnamese Ministry of Health (5044/QĐ-BYT).
Trial registration: Clinicaltrials.gov: NCT03854929 (February 26th 2019)
Class based Influence Functions for Error Detection
Influence functions (IFs) are a powerful tool for detecting anomalous
examples in large scale datasets. However, they are unstable when applied to
deep networks. In this paper, we provide an explanation for the instability of
IFs and develop a solution to this problem. We show that IFs are unreliable
when the two data points belong to two different classes. Our solution
leverages class information to improve the stability of IFs. Extensive
experiments show that our modification significantly improves the performance
and stability of IFs while incurring no additional computational cost.Comment: Thang Nguyen-Duc, Hoang Thanh-Tung, and Quan Hung Tran are co-first
authors of this paper. 12 pages, 12 figures. Accepted to ACL 202
Carbon dioxide reforming of methane over modified iron-cobalt alumina catalyst : Role of promoter
Cobalt-based catalysts are widely employed in methane dry reforming but tend to deactivate quickly due to coke deposits and metal sintering. To enhance the performance, iron, a cost-effective promoter, is added, improving cobalt's metal dispersibility, reducibility, and basicity on the support. This addition accelerates carbon gasification, effectively inhibiting coke deposition. Methods: A series of iron-doped cobalt alumina MFe-5Co/Al2O3 (M= 0, 0.4, 0.8, 1, 2 wt.%) were prepared via simple incipient-wetness impregnation. The catalysts were thoroughly characterized via modern techniques including BET, XRD, H2-TPR, CO2-TPD. Significant findings: The addition of iron had a minimal impact on the properties of γ-Al2O3, but it significantly affected the dispersibility of cobalt. At an optimal dosage of 0.8 wt.%, there was a notable decrease of 29.44% in Co3O4 particle size. However, excessive iron loading induced agglomeration of Co3O4, which was reversible. The presence of iron also resulted in a decrease in the reduction temperature of Co3O4. The material's basicity was primarily influenced by the loading of iron, reaching its highest value of 705.7 μmol CO2 g−1 in the 2Fe-5Co/Al2O3. The correlation between catalytic activity and the physicochemical properties of the material was established. The 0.8Fe-5Co/Al2O3 sample exhibited excellent performance due to the favorable dispersibility of cobalt, its reducibility, and its affordable basicity
- …