5,239 research outputs found
Pneumocystis carinii versus Pneumocystis jiroveci: Another Misnomer (Response to Stringer et al.)
Simultaneous computation of dynamical and equilibrium information using a weighted ensemble of trajectories
Equilibrium formally can be represented as an ensemble of uncoupled systems
undergoing unbiased dynamics in which detailed balance is maintained. Many
non-equilibrium processes can be described by suitable subsets of the
equilibrium ensemble. Here, we employ the "weighted ensemble" (WE) simulation
protocol [Huber and Kim, Biophys. J., 1996] to generate equilibrium trajectory
ensembles and extract non-equilibrium subsets for computing kinetic quantities.
States do not need to be chosen in advance. The procedure formally allows
estimation of kinetic rates between arbitrary states chosen after the
simulation, along with their equilibrium populations. We also describe a
related history-dependent matrix procedure for estimating equilibrium and
non-equilibrium observables when phase space has been divided into arbitrary
non-Markovian regions, whether in WE or ordinary simulation. In this
proof-of-principle study, these methods are successfully applied and validated
on two molecular systems: explicitly solvated methane association and the
implicitly solvated Ala4 peptide. We comment on challenges remaining in WE
calculations
Using a novel climate-water conflict vulnerability index to capture double exposures in Lake Chad
Climate variability is amongst an array of threats facing agricultural livelihoods, with its effects unevenly distributed. With resource conflict being increasingly recognised as one significant outcome of climate variability and change, understanding the underlying drivers that shape differential vulnerabilities in areas that are double exposed to climate and conflict has great significance. Climate change vulnerability frameworks are rarely applied in water conflict research. This article presents a composite climate–water conflict vulnerability index based on a double exposure framework developed from advances in vulnerability and livelihood assessments. We apply the index to assess how the determinants of vulnerability can be useful in understanding climate variability and water conflict interactions and to establish how knowledge of the climate–conflict linked context can shape interventions to reduce vulnerability. We surveyed 240 resource users (farmers, fishermen and pastoralists) in seven villages on the southeastern shores of Lake Chad in the Republic of Chad to collect data on a range of exposure, sensitivity and adaptive capacity variables. Results suggest that pastoralists are more vulnerable in terms of climate-structured aggressive behaviour within a lake-based livelihoods context where all resource user groups show similar levels of exposure to climate variability. Our approach can be used to understand the human and environmental security components of vulnerability to climate change and to explore ways in which conflict-structured climate adaptation and climate-sensitive conflict management strategies can be integrated to reduce the vulnerability of populations in high-risk, conflict-prone environments
Protection of stainless-steels against corrosion in sulphidizing environments by Ce oxide coatings: X-ray absorption and thermogravimetric studies
In this paper a study is reported concerning ceramic coatings containing cerium oxide, prepared by the sol-gel method, used to protect Incoloy 800H against sulphidation. When the coating is sintered in air at 850°C good protection is obtained. In an X-ray absorption spectroscopic study of the coatings it was observed that the best protective coating contains all cerium as CeIV after pretreatment. After sulphidizing cerium was reduced to CeIII. Possible mechanisms to explain the protective properties are discussed
COVID‐19: The Uninvited Guest in the Intensive Care Unit — Implications for Pharmacotherapy
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/155543/1/phar2394.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/155543/2/phar2394_am.pd
A new dryland development paradigm grounded in empirical analysis of dryland systems science
Global drylands face a host of urgent human and environmental challenges with far-reaching impacts. Improving smallholder agriculture remains a key development pathway to tackle these challenges. The Dryland Development Paradigm (DDP), introduced in 2007, presented a highly influential framework for dryland development based on systems research. This paper empirically derives a new, updated DDP. It assesses recent, cutting-edge dryland science, combining literature review with qualitative and quantitative analysis of research published by the world's largest dryland science and development research initiative. The new DDP comprises eight characteristics that are distilled into three integrative principles: Unpack, Traverse and Share. The new DDP is applied and tested to identify key dryland knowledge and development gaps. A future research agenda is then elucidated, grounded in a research in development approach, in which research anchored in the three integrative principles is embedded within the context it seeks to improve. Supported by greater transdisciplinarity and knowledge co-production, operationalization of the new DDP can deliver both novel scientific insights and development impact in line with the aspirations of the 2030 Sustainable Development Goals
Sir Arthur Keith's Legacy: Re-discovering a lost collection of human fossils Quaternary International
In 2001, a collection of skeletal material was donated to the Natural History Museum, London, by the Royal College of Surgeons, London. It consisted of boxes discovered among the personal belongings of Sir Arthur Keith. This paper describes the work undertaken to identify and document the human skeletal material in the Keith Collection. The study identified the human fossils as having come from a number of excavations directed by Dorothy Garrod in the 1920s and 30s in Israel. The collection contains the long considered lost human skeletal collection from the type-site of the Natufian industry: Shukbah Cave. The majority of this material is of Natufian origin but contains a few Neanderthal specimens. A small amount of heavily fragmented bones associated with Skhul VII and IX were also found. The most remarkable of the re-discovered collection is the material from el-Wad and Kebara Caves. It was identified to be the missing material from the Middle and Upper Paleolithic levels briefly described in 1939 in The Stone Age of Mount Carmel by Theodore McCown and Sir Arthur Keith. These important fossils hold great potential to answer questions about the Middle to Upper Paleolithic transition in the Near East, and the emergence of anatomically modern humans
Improving yield and cane quality through implementation of harvesting best practice-2019 Herbert demonstration
In 2019, the Australian sugarcane industry conducted a month-long demonstration with 12 trials to determine the commercial viability of harvesting best practice. Initiated by a small group of innovative growers and contractors from the Herbert region, the concept of a commercial demonstration sought to determine both agronomic and economic impacts of adopting HBP, including the assessment of possible yield gains without having a detrimental impact on extraneous matter, and economic implication for growers and harvesting contractors arising from revenue and harvesting cost changes. Two Herbert harvesting contractors participated in the demonstration comparing their standard harvesting practices to Sugar Research Australia Harvesting Best Practice (HBP or recommended practice). The results identified an average 4.8 t/ha increase in yield with no additional increase in extraneous matter for the recommended
setting. A comprehensive economic analysis was conducted on each of the trials. Detailed harvesting costs and operational information, including machinery, labour, and fuel data, were collected from the respective harvesting operations. Harvesting costs and levies were 0.07/t) higher for the recommended setting due to higher yields, reduced harvester ground speeds and lower extractor fan speeds. Despite the higher harvesting costs, recommended settings obtained significantly higher total revenue (114/ha in the adoption of recommended settings (based on a 4.4% higher net revenue calculated as total grower revenue minus harvesting costs and levies). The Herbert demonstrations have proven instrumental in the acceptance of harvesting best practice for the region. The results again confirm that adapting and aligning commercial-scale harvesting practices to crop and paddock conditions have positive impacts on both yield and economic outcomes
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