LDB1 (LIM domain binding 1)

Review on LDB1 (LIM domain binding 1), with data on DNA, on the protein encoded, and where the gene is implicated

HOMOGENIZATION OF COMPOSITE BEAMS WITH PERIODIC MICROSTRUCTURES

The Thirteenth East Asia-Pacific Conference on Structural Engineering and Construction (EASEC-13), September 11-13, 2013, Sapporo, Japan

The effects of PSK, a biological response

The antiteratogenic effects of PSK, a biological response modifier, were examined using histological and developmental analysis. The whole bodies of pregnant mice were irradiated with X-rays and injected with PSK within ten minutes after irradiation on day 7 of gestation (E7). The foetuses on E18 were examined and a high incidence of malformations were observed in X-ray irradiated embryos. Microphthalmia was the most frequent malformation. PSK administration suppressed the X-ray irradiation-induced ocular anomalies in not only the frequency, as deduced by external observation. but also in histopathological changes in the retina, lens, and cornea. In particular. the incidence of lens aplasia was significantly decreased by PSK administration. Developmental analysis using E10 and E13 embryos revealed that the decrease in the incidence of histopathological changes was first observed within 72 hours after PSK administration. In addition, X-ray irradiation-induced early foetal death (E 1 O- 13) was also suppressed by PSK administration. The possible mechanisms of the antiteratogenic effects of PSK are discussed

Chronic retinal effects by ultraviolet irradiation, with special reference to superoxide dismutases

Recently ultraviolet light (UV) reaching the Earth's surface has been gradually increasing in amounts by the destruction of the ozone layers. Large parts of UV are absorbed in the cornea and lens, and only a few amounts reach the retina; however, the effect on the retina is not fully elucidated. 38 rats were irradiated 0.5- 5.0 ~ / c mUV~ f rom 6 to 50 times every 24 hours, and their retinal effects were investigated morphologicaily, immunohistochemically and immunochemically for superoxide dismutases (SOD). Morphologically, the destruction of rod outer segments (ROS) and dissociation of cell membranes between the pigment epithelial cells (PE) were already observed by 6 times 0.5 ~ / c mUV~ i rradiations. As the doses of UV increased, heterochromatins and lipid droplets increased in the PE. Significant damage was not observed, except in ROS and PE. In normal retina, CuIZn SOD were mainly distributed from the inner limiting membrane (ILM) to the ganglion cell layer, and the PE; however, after 6 times 0.5 ~ / c mUV~ i rradiations, the distribution became widened from inner to outer plexiform layer (OPL). At that time, the concentrations of CuKn and Mn SOD increased in the retina. The present study reveals that the morphological damage caused by UV irradiation is observed in the ROS and PE, where no immunoreactivities could be detected to CuIZn and Mn SOD. However, morphological damage was not from the ILM to OPL, where the imrnunoreactivities to both Cu/Zn and Mn SOD were observed