Organization and management of clusters in Russia in the context of import substitution

The article covers the trends of the agribusiness development in Russia. It is shown that it is desirable to develop organizational-economic forms of entrepreneurship based on the cluster approach in the modern realities. The most famous agribusiness clusters in the world are explored. Regions of Russia that have achieved the most significant results in agribusiness clustering are mentioned. It is found that the establishment of agribusiness in Russia is defined by the political decision of regional authorities rather than based on research and development. An algorithm for establishing the agribusiness cluster is proposed, which includes four stages: methodological, analytical, organizational-economic and control. The key areas of state support for the development of agribusiness clusters in Russia are defined.peer-reviewe

КОМОРБИДНАЯ КАРДИОРЕСПИРАТОРНАЯ ПАТОЛОГИЯ И ПОВЕДЕНЧЕСКИЕ ФАКТОРЫ РИСКА: НОВЫЙ ВЗГЛЯД НА СТАРУЮ ПРОБЛЕМУ

The material for the study included patients with chronic obstructive pulmonary disease (COPD) in association with arterial hypertension (AH) II stage – 50 people. A comprehensive clinical and functional study of the assessment of emotional status. Found that with the increase of the severity of COPD and hypertension increases the frequency and severity of cognitive impairment up to dementia.Материалом для исследования послужили пациенты с хронической обструктивной болезнью лег-ких (ХОБЛ) в ассоциации с артериальной гипертензией (АГ) II стадии – 50 человек. Проведено комплексное клинико-функциональное исследование с оценкой психоэмоционального статуса. Установлено, что с нарастанием степени тяжести ХОБЛ и АГ увеличивается частота и выраженность когнитивных нарушений вплоть до деменции

Automatic structures of bounded degree revisited

The first-order theory of a string automatic structure is known to be decidable, but there are examples of string automatic structures with nonelementary first-order theories. We prove that the first-order theory of a string automatic structure of bounded degree is decidable in doubly exponential space (for injective automatic presentations, this holds even uniformly). This result is shown to be optimal since we also present a string automatic structure of bounded degree whose first-order theory is hard for 2EXPSPACE. We prove similar results also for tree automatic structures. These findings close the gaps left open in a previous paper of the second author by improving both, the lower and the upper bounds.Comment: 26 page

Outcomes in poor responders treated with in vitro fertilization/intracytoplasmic sperm injection according to bologna criteria

Purpose of the study was to evaluate the effectiveness of various approaches of artificial reproductive technologies (ART) in advanced maternal age patients with poor ovarian response (POR). Materials and methods. This is retrospective cohort study of 455 patients with POR who have undergone an IVF and embryo transfer program at from June 2016 to June 2018. Researchers evaluated pregnancy rate (PR) per embryo transferand live birth rate (LBR) per embryo transferas in vitro fertilization (IVF) outcomes. The patients fulfilled Bologna criteria were divided into 5 groups: long protocol, ant-gonadotropin-releasing hormone protocol, freeze embryos transfer without preimplantation genetic diagnostic (PGS), freeze embryos transfer with PGS, natural cycle. Results. There was no statistically significant difference in the age, Anti-Müllerian hormone level and duration of infertility between the groups. Despite different protocols of ovarian stimulation, there was no statistically significant difference in pregnancy rate in fresh cycles. At the same time, cancellation of transfer was significantly higher observed in natural cycles (p <0.001). PR and LBR were statistically significant higher in freeze embryo transfer group 29% and 12.1% vs 13.3% and 5,5% respectively (p<0.001 and p = 0.040). During the transfer of the embryo unexamined by PGS and after PGS the pregnancy rate did not differ (29.4% vs 28.2%, p <0.05), but LBR was statistically significant higher after euploid embryo transfer (8.2% without PGS vs 20.5% after PGS, p = 0.028). Conclusion. The most effective approach in patients with a poor ovarian response was cycle segmentation, cryopreservation of embryos, PGS and transfer of an euploid embryo. This category of patients requires a personalized approach to the treatment of infertility. The choice of protocol in ART program must be carried out with the full voluntary and informed consent of the patient, depending on their desires and capabilities, including financial

Fiziobalneoterapy distsirkulyatorna of hypertensive genez's associated with the vibrating illness encephalopathy

In researches on 67 miners with distsirkulyatorny encephalopathy hypertensive генеза, associated with a vibrating illness, positive influence of a complex fiziobalneoterapiya with sochetanny use of low-frequency pulse currents and a variation magnetic field against the general yodo-bromine hloridny sodium baths on indicators of cognitive functions and the emotional and strong-willed sphere, and also the general and regional haemo dynamics is shown.В исследованиях на 67 горнорабочих с дисциркуляторной энцефалопатией гипертонического генеза, ассоциированной с вибрационной болезнью, показано позитивное влияние комплексной физиобальнеотерапии с сочетанным использованием низкочастотных импульсных токов и переменного магнитного поля на фоне общих йодо-бромных хлоридных натриевых ванн на показатели когнитивных функций и эмоционально-волевой сферы, а также общей и региональной гемодинамики

Non-conventional risk factors progression chronic obstructive pulmonary disease associated with hypertension

In order to study the role of psychosocial risk factors in the progression of COPD in combination with hypertension were examined 82 patients aged 40-59 years with COPD of moderate severity in partial remission stage and stage II hypertension. All subjects were divided into 2 groups: Group 1 - 49 patients with COPD, group 2 - 33 patients with COPD in association with GB. All patients underwent a complete clinical and functional study and evaluation of non-conventional risk factors. The study obtained correlations of clinical and functional parameters with non-conventional risk factors proving their adverse effects on the progression of COPD as well as hypertension.С целью изучения роли психосоциальных факторов риска в прогрессировании ХОБЛ в сочетании с гипертонической болезнью было обследовано 82 пациента в возрасте 40-59 лет с ХОБЛ средней степени тяжести в стадии неполной ремиссии и ГБ II стадии. Все обследованные были разделены на 2 группы: 1 группа - 49 больных ХОБЛ, 2 группа — 33 больных ХОБЛ в ассоциации с ГБ. Всем пациентам проводилось комплексное клинико-функциональное исследование и оценка неконвенционных факторов риска. В результате проведенного исследования получены корреляционные взаимосвязи клинико-функциональных показателей с неконвенционными факторами риска доказывающих их отрицательное воздействие на прогрессирование как ХОБЛ, так и гипертонической болезни

ВОЗМОЖНОСТИ СТАБИЛОГРАФИЧЕСКОГО ИССЛЕДОВАНИЯ ДЛЯ ОЦЕНКИ УСТОЙЧИВОСТИ ВЕРТИКАЛЬНОЙ ПОЗЫ У РАБОТНИКОВ, ЗАНЯТЫХ В УСЛОВИЯХ ВОЗДЕЙСТВИЯ ПРОИЗВОДСТВЕННОЙ ВИБРАЦИИ

The aim of this study was to evaluate the possibility of using stabilography for identifying postural imbalance in workers exposed to industrial vibration. A total of 97 workers of the JSC «Minsk Automobile Plant» exposed to industrial vibration were recruited. The main stabilographic parameters characterizing the stability of the vertical posture and the degree of plantar information used for maintaining balance of workers were analyzed. We identified postural changes indicating the disturbances of proprioceptive sensitivity in workers exposed to industrial vibration more than 5 years.Проведенное исследование заключалось в оценке возможностей стабилографического исследования для выявления постуральной дисбаланса у рабочих, подвергающихся воздействию промышленной вибрации. Проанализированы основные стабилографические параметры, характеризующие устойчивость вертикальной позы, а также плантарный коэффициент, характеризующий степень использования плантарной информации для поддержания равновесия. Авторы определили постуральные изменения, указывающие на нарушения проприоцептивной чувствительности у рабочих, подвергающихся воздействию промышленной вибрации более 5 лет

A Naturally Occurring Polymorphism at Drosophila melanogaster Lim3 Locus, a Homolog of Human LHX3/4, Affects Lim3 Transcription and Fly Lifespan

Lim3 encodes an RNA polymerase II transcription factor with a key role in neuron specification. It was also identified as a candidate gene that affects lifespan. These pleiotropic effects indicate the fundamental significance of the potential interplay between neural development and lifespan control. The goal of this study was to analyze the causal relationships between Lim3 structural variations, and gene expression and lifespan changes, and to provide insights into regulatory pathways controlling lifespan. Fifty substitution lines containing second chromosomes from a Drosophila natural population were used to analyze the association between lifespan and sequence variation in the 5′-regulatory region, and first exon and intron of Lim3A, in which we discovered multiple transcription start sites (TSS). The core and proximal promoter organization for Lim3A and a previously unknown mRNA named Lim3C were described. A haplotype of two markers in the Lim3A regulatory region was significantly associated with variation in lifespan. We propose that polymorphisms in the regulatory region affect gene transcription, and consequently lifespan. Indeed, five polymorphic markers located within 380 to 680 bp of the Lim3A major TSS, including two markers associated with lifespan variation, were significantly associated with the level of Lim3A transcript, as evaluated by real time RT-PCR in embryos, adult heads, and testes. A naturally occurring polymorphism caused a six-fold change in gene transcription and a 25% change in lifespan. Markers associated with long lifespan and intermediate Lim3A transcription were present in the population at high frequencies. We hypothesize that polymorphic markers associated with Lim3A expression are located within the binding sites for proteins that regulate gene function, and provide general rather than tissue-specific regulation of transcription, and that intermediate levels of Lim3A expression confer a selective advantage and longer lifespan