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An interactive multi-block grid generation system

A grid generation procedure combining interactive and batch grid generation programs was put together to generate multi-block grids for complex aircraft configurations. The interactive section provides the tools for 3D geometry manipulation, surface grid extraction, boundary domain construction for 3D volume grid generation, and block-block relationships and boundary conditions for flow solvers. The procedure improves the flexibility and quality of grid generation to meet the design/analysis requirements

Josephson glass and decoupling of flux lattices in layered superconductors

Phase transitions of a flux lattice in layered superconductors with magnetic field perpendicular to the layers and in presence of disorder are studied. We find that the Josephson coupling between layers leads to a strongly pinned Josephson glass (JG) phase at low temperatures and fields. The JG phase undergoes either a decoupling transition with increasing field or a depinning transition with increasing temperature. The resulting phases undergo further depinning and decoupling transitions, respectively, resulting in a phase diagram with a multicritical point where four phases meet. The phase diagram accounts for unusual data on Bi_2Sr_2CaCu_2O_8 such as the "second peak" transition and the recently observed depinning transitions.Comment: 5 pages, 1 eps figure, Revtex, Phys. Rev. Lett. (submitted

Review: Do the Different Sensory Areas within the Cat Anterior Ectosylvian Sulcal Cortex Collectively Represent a Network Multisensory Hub?

Current theory supports that the numerous functional areas of the cerebral cortex are organized and function as a network. Using connectional databases and computational approaches, the cerebral network has been demonstrated to exhibit a hierarchical structure composed of areas, clusters and, ultimately, hubs. Hubs are highly connected, higher-order regions that also facilitate communication between different sensory modalities. One region computationally identified network hub is the visual area of the Anterior Ectosylvian Sulcal cortex (AESc) of the cat. The Anterior Ectosylvian Visual area (AEV) is but one component of the AESc that also includes the auditory (Field of the Anterior Ectosylvian Sulcus - FAES) and somatosensory (Fourth somatosensory representation - SIV). To better understand the nature of cortical network hubs, the present report reviews the biological features of the AESc. Within the AESc, each area has extensive external cortical connections as well as among one another. Each of these core representations is separated by a transition zone characterized by bimodal neurons that share sensory properties of both adjoining core areas. Finally, core and transition zones are underlain by a continuous sheet of layer 5 neurons that project to common output structures. Altogether, these shared properties suggest that the collective AESc region represents a multiple sensory/multisensory cortical network hub. Ultimately, such an interconnected, composite structure adds complexity and biological detail to the understanding of cortical network hubs and their function in cortical processing

Chemistry

published or submitted for publicatio

The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease

Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main pathological features of AD is the presence in the brain of senile plaques mainly composed of aggregated β amyloid (Aβ), a derivative of the longer amyloid precursor protein (APP). The amyloid hypothesis proposes that the accumulation of Aβ within neural tissue is the initial event that triggers the disease. Here we review research efforts that have attempted to inhibit the generation of the Aβ peptide through modulation of the activity of the proteolytic secretases that act on APP and discuss whether this is a viable therapeutic strategy for treating AD.<p></p> Alzheimer's disease (AD) is the most common form of dementia in the elderly but as yet there are no drugs that can halt the progression of this disease. In a theory called the ‘amyloid hypothesis’, researchers have proposed that the accumulation of a small protein fragment called beta amyloid or Aβ within brain tissue is the event which triggers Alzheimer's disease. Aβ is a derivative of the longer amyloid precursor protein (APP). Here we review research efforts that have attempted to inhibit the generation of Aβ through modulation of proteins called secretases which cut APP into Aβ. Author edits made on: 20 May 2015

Hydraulics and geology related to beach restoration in Lee County, Florida

The erosion problem on Captiva Island is discussed. It is due to a deficit in the sand budget of the littoral drift system; a system with losses due to attrition of the particles and mass losses into the lagoons, to offshore, and to lateral transport. The effect that reopening Blind Pass would have, and the placement of sediment retaining structures in the surf zone at the northern and southern limits of the Captiva beach system, wave examined. A geological approach was used to study the origin and dynamic changes that have occurred. Through hydraulic modeling, changes that will occur by reopening and stabilizing Blind Pass are predicted. It is concluded that if the island is to be stabilized, beach nourishment with proper amounts and particle size is a necessity and that jetties adequate to restrict lateral and offshore losses are essential. It is shown that the reopening of Blind Pass would have minimal effects on the passes to the north and south, and would improve the environmental conditions in the sound with no adverse effects on the beach system

Variation in HIV-1 set-point viral load: epidemiological analysis and an evolutionary hypothesis.

The natural course of HIV-1 infection is characterized by a high degree of heterogeneity in viral load, not just within patients over time, but also between patients, especially during the asymptomatic stage of infection. Asymptomatic, or set-point, viral load has been shown to correlate with both decreased time to AIDS and increased infectiousness. The aim of this study is to characterize the epidemiological impact of heterogeneity in set-point viral load. By analyzing two cohorts of untreated patients, we quantify the relationships between both viral load and infectiousness and the duration of the asymptomatic infectious period. We find that, because both the duration of infection and infectiousness determine the opportunities for the virus to be transmitted, this suggests a trade-off between these contributions to the overall transmission potential. Some public health implications of variation in set-point viral load are discussed. We observe that set-point viral loads are clustered around those that maximize the transmission potential, and this leads us to hypothesize that HIV-1 could have evolved to optimize its transmissibility, a form of adaptation to the human host population. We discuss how this evolutionary hypothesis can be tested, review the evidence available to date, and highlight directions for future research