Reconceptualising academic development as community development: lessons from working with Syrian academics in exile

This paper focuses on academic development for Syrian academics in exile. Academic development first emerged in resource-rich, global North environments including the UK, the USA, Australia, and Scandinavia nearly 50 years ago as reported by Gosling (International Journal for Academic Development, 14(1):5–18, 2009), and the majority of research studies in this field focus on activities in global North, resource-rich, institutional settings. Yet academics in resource-poor, [post-] conflict and post-colonial contexts face different challenges and circumstances, and have different academic development needs. This paper extends the conceptual and contextual scope of this field by investigating the experiences and academic development needs of Syrian academics in exile, and interrogating the concept of academic development within that context. It establishes the background context of Syrian academia in exile, before summarising the nature and aims of the Council for At Risk Academics (Cara) Syria Programme. It then outlines the study’s methodology, before presenting the findings of a thematic analysis of a multi-level data set. It then interrogates the concept and normative terrain of academic development in light of these findings, and proposes a model for academic community development to support academic communities in exile, and marginalised academic communities more widely

Cellular and Synaptic Actions of Acetylcholine in the Lamprey Spinal Cord

This study investigated cellular and synaptic mechanisms of cholinergic neuromodulation in the in vitro lamprey spinal cord. Most spinal neurons tested responded to local application of acetylcholine (ACh) with depolarization and decreased input resistance. The depolarization persisted in the presence of either tetrodotoxin or muscarinic antagonist scopolamine and was abolished with nicotinic antagonist mecamylamine, indicating a direct depolarization through nicotinic ACh receptors. Local application of muscarinic ACh agonists modulated synaptic strength in the spinal cord by decreasing the amplitude of unitary excitatory and inhibitory postsynaptic potentials. The postsynaptic response to direct application of glutamate was unchanged by muscarinic agonists, suggesting a presynaptic mechanism. Cholinergic feedback from motoneurons was assessed using stimulation of a ventral root in the quiescent spinal cord while recording intracellularly from spinal motoneurons or interneurons. Mainly depolarizing potentials were observed, a portion of which was insensitive to removal of extracellular Ca2+, indicating electrotonic coupling. Hyperpolarizing potentials were also observed and were attenuated by the glycinergic antagonist strychnine, whereas depolarizing responses were potentiated by strychnine. Mecamylamine also reduced hyperpolarizing responses. The pharmacology of these responses suggests a Renshaw-like feedback pathway in lamprey. Immunohistochemistry for choline acetyltransferase, performed in combination with retrograde filling of motoneurons, demonstrated a population of nonmotoneuron cholinergic cells in the lamprey spinal cord. Thus endogenous cholinergic modulation of the lamprey spinal locomotor network is likely produced by both motoneurons and cholinergic interneurons acting via combined postsynaptic and presynaptic actions

The Merging History of Massive Black Holes

We investigate a hierarchical structure formation scenario describing the evolution of a Super Massive Black Holes (SMBHs) population. The seeds of the local SMBHs are assumed to be 'pregalactic' black holes, remnants of the first POPIII stars. As these pregalactic holes become incorporated through a series of mergers into larger and larger halos, they sink to the center owing to dynamical friction, accrete a fraction of the gas in the merger remnant to become supermassive, form a binary system, and eventually coalesce. A simple model in which the damage done to a stellar cusps by decaying BH pairs is cumulative is able to reproduce the observed scaling relation between galaxy luminosity and core size. An accretion model connecting quasar activity with major mergers and the observed BH mass-velocity dispersion correlation reproduces remarkably well the observed luminosity function of optically-selected quasars in the redshift range 1<z<5. We finally asses the potential observability of the gravitational wave background generated by the cosmic evolution of SMBH binaries by the planned space-born interferometer LISA.Comment: 4 pages, 2 figures, Contribute to "Multiwavelength Cosmology", Mykonos, Greece, June 17-20, 200

Surface climatological information - Twenty selected stations for space shuttle studies

Surface climatological data for twenty selected launch, landing, and alternate landing sites for space shuttle syste

Far-Term Exploration of Advanced Single-Aisle Subsonic Transport Aircraft Concepts

Far-term single-aisle class aircraft concepts for potential entry-into-service of 2045 were investigated using an Interactive Reconfigurable Matrix of Alternatives (IRMA) approach. The configurations identified through this design space exploration were then distilled into three advanced aircraft concepts best characterizing the prominent features identified through the IRMA exploration. These three aircraft concepts were then configured and sized for a 150-passenger capacity and a 3,500 nautical mile design mission. Mission block fuel burn was estimated and compared to a far-term conventional configuration baseline concept and a 2005 l. These comparisons suggest considerable potential improvements in fuel efficiency from the investigated advanced concepts

A New Family of Multistep Methods with Improved Phase Lag Characteristics for the Integration of Orbital Problems

In this work we introduce a new family of ten-step linear multistep methods for the integration of orbital problems. The new methods are constructed by adopting a new methodology which improves the phase lag characteristics by vanishing both the phase lag function and its first derivatives at a specific frequency. The efficiency of the new family of methods is proved via error analysis and numerical applications.Comment: 21 pages, 3 figures, 1 tabl

Cholinergic Modulation of the Locomotor Network in the Lamprey Spinal Cord

Acetylcholine (ACh) was found here to be a strong modulator of swimming activity in the isolated spinal cord preparation of the adult lamprey (Ichthyomyzon unicuspis). During fictive swimming induced with either D-glutamate or N-methyl-D-aspartate, addition of ACh (200 µM) significantly reduced the cycle period of ventral root bursts to 54%, intersegmental phase lag to 32%, and ventral root burst proportion to 80% of control levels. Effects of ACh were apparent at concentrations as low as 1 µM. Both nicotinic and muscarinic receptors are involved, in that application of either nicotinic or muscarinic agonists alone significantly reduced cycle period. There is sufficient endogenous ACh in the spinal cord to modulate ongoing fictive swimming, as shown by application of the cholinesterase inhibitor eserine (physostigmine). Eserine (20 µM) significantly reduced the cycle period to 78% and phase lag to 58% of control levels, and these effects were reversed with the addition of cholinergic blockers. Addition of only a nicotinic or muscarinic antagonist, mecamylamine (10 µM) or scopolamine (20 µM), respectively, to the spinal cord during fictive swimming produced significant increases in cycle period and phase lag, suggesting that both types of cholinergic receptors participate in endogenous cholinergic modulation. It is concluded that ACh is an endogenous modulator of the locomotor network in the lamprey spinal cord and that ACh may take part in the regulation of cycle period, intersegmental coupling, and ventral root burst duration