From internet architecture research to standards

Many Internet architectural research initiatives have been undertaken over last twenty years. None of them actually reached their intended goal: the evolution of the Internet architecture is still driven by its protocols not by genuine architectural evolutions. As this approach becomes the main limiting factor of Internet growth and application deployment, this paper proposes an alternative research path starting from the root causes (the progressive depletion of the design principles of the Internet) and motivates the need for a common architectural foundation. For this purpose, it proposes a practical methodology to incubate architectural research results as part of the standardization process

First-order transition in small-world networks

The small-world transition is a first-order transition at zero density $p$ of shortcuts, whereby the normalized shortest-path distance undergoes a discontinuity in the thermodynamic limit. On finite systems the apparent transition is shifted by $\Delta p \sim L^{-d}$. Equivalently a ``persistence size'' $L^* \sim p^{-1/d}$ can be defined in connection with finite-size effects. Assuming $L^* \sim p^{-\tau}$, simple rescaling arguments imply that $\tau=1/d$. We confirm this result by extensive numerical simulation in one to four dimensions, and argue that $\tau=1/d$ implies that this transition is first-order.Comment: 4 pages, 3 figures, To appear in Europhysics Letter

A novel detrimental homozygous mutation in the WFS1 gene in two sisters from nonconsanguineous parents with untreated diabetes insipidus

Given the limited lifespan and with the recent progress in experimental treatments for WS, timely diagnosis and multidisciplinary treatment for DI/DM, hydronephrosis, and visual/psychiatric status-maintaining quality of life-are of crucial importance

Holographic Renormalization of general dilaton-axion gravity

We consider a very general dilaton-axion system coupled to Einstein-Hilbert gravity in arbitrary dimension and we carry out holographic renormalization for any dimension up to and including five dimensions. This is achieved by developing a new systematic algorithm for iteratively solving the radial Hamilton-Jacobi equation in a derivative expansion. The boundary term derived is valid not only for asymptotically AdS backgrounds, but also for more general asymptotics, including non-conformal branes and Improved Holographic QCD. In the second half of the paper, we apply the general result to Improved Holographic QCD with arbitrary dilaton potential. In particular, we derive the generalized Fefferman-Graham asymptotic expansions and provide a proof of the holographic Ward identities.Comment: 42 pages. v2: two references added. Version published in JHEP. v3: fixed minor typos in eqs. (1.6), (2.3), (3.20), (A.3), (B.8), (B.12) and (B.22

Interior Point Decoding for Linear Vector Channels

In this paper, a novel decoding algorithm for low-density parity-check (LDPC) codes based on convex optimization is presented. The decoding algorithm, called interior point decoding, is designed for linear vector channels. The linear vector channels include many practically important channels such as inter symbol interference channels and partial response channels. It is shown that the maximum likelihood decoding (MLD) rule for a linear vector channel can be relaxed to a convex optimization problem, which is called a relaxed MLD problem. The proposed decoding algorithm is based on a numerical optimization technique so called interior point method with barrier function. Approximate variations of the gradient descent and the Newton methods are used to solve the convex optimization problem. In a decoding process of the proposed algorithm, a search point always lies in the fundamental polytope defined based on a low-density parity-check matrix. Compared with a convectional joint message passing decoder, the proposed decoding algorithm achieves better BER performance with less complexity in the case of partial response channels in many cases.Comment: 18 pages, 17 figures, The paper has been submitted to IEEE Transaction on Information Theor

The holographic quantum effective potential at finite temperature and density

We develop a formalism that allows the computation of the quantum effective potential of a scalar order parameter in a class of holographic theories at finite temperature and charge density. The effective potential is a valuable tool for studying the ground state of the theory, symmetry breaking patterns and phase transitions. We derive general formulae for the effective potential and apply them to determine the phase transition temperature and density in the scaling region.Comment: 27 page

Subventricular zone stem cells are heterogeneous with respect to their embryonic origins and neurogenic fates in the adult olfactory bulb

Wedetermined the embryonic origins of adult forebrain subventricular zone (SVZ) stem cells by Cre-lox fate mapping in transgenic mice. We found that all parts of the telencephalic neuroepithelium, including the medial ganglionic eminence and lateral ganglionic eminence (LGE) and the cerebral cortex, contribute multipotent, self-renewing stem cells to the adult SVZ. Descendants of the embryonic LGE and cortex settle in ventral and dorsal aspects of the dorsolateral SVZ, respectively. Both populations contribute new (5-bromo-2(')-deoxyuridine- labeled) tyrosine hydroxylase- and calretinin-positive interneurons to the adult olfactory bulb. However, calbindin-positive interneurons in the olfactory glomeruli were generated exclusively by LGE- derived stem cells. Thus, different SVZ stem cells have different embryonic origins, colonize different parts of the SVZ, and generate different neuronal progeny, suggesting that some aspects of embryonic patterning are preserved in the adult SVZ. This could have important implications for the design of endogenous stem cell-based therapies in the future