[Control Methods for Ants, Stinging Pests, Beetles, Moths, Cockroaches, and Occasional Invaders]

This field reference is for beginning pest control operators with little or no experience. This is a state-specific reference to the structural pest control of Long Island, New York. Includes descriptions of control methods for ants, stinging pests, beetles, moths, cockroaches, and occasional invaders

Emergency Medical Care and Podiatry

Exam paper for first semester (Department of Applied Physics and Engineering Mathematics, B. Tech

Modelling the influence of the froth phase on recovery in batch and continuous flotation cells

To determine model parameters, a large data set was required. This is due to the semi-empirical nature of the proposed froth model. In this regard, the use of data obtained from continuously operated cells was therefore not suitable for deriving model parameters. It was thought that this could only be achieved by using data obtained from a batch flotation cell. A batch flotation cell has a distinct advantage of being suitable for generating, rapidly, large amount of data. However, the non-steady behaviour of froths found in this type of cell require a robust methodology for extracting the necessary parameters. In return this methodology was developed in this thesis. The main hypothesis of this methodology is that batch flotation performance, in terms of recovery, can be adequately approximated by treating a batch test as if it consists of a series of tests carried out in continuously operated flotation cells. Each flotation time interval is regarded as a single stage. Treating batch data in this manner allows for the derivation of desired kinetic parameters to describe flotation performance

Possible modulation of dopaminergic neurotransmission function by acetyl-L-carnitine

Acetyl‐L‐Carnitine (ALC) has a putative neuroprotective effect being used in a variety of conditions. Nevertheless, the underlying molecular mechanisms, particularly regarding the induction of changes in neurotransmitter systems, are still not fully understood. We aim to contribute for the elucidation of the mechanisms by which ALC alters neurotransmitter release, using a cell line and an animal model of exposure to methamphetamine (METH). PC12 cells were incubated with several doses of ALC (0.01 to 1.0 mM) alone or in combination with METH 1.0 or 100 µM for 24h or 72h. When combined, ALC preceded METH administration in 30 minutes. Dopamine (DA) content was determined by high performance liquid chromatography. C57BL/6J mice were used for in vivo assays to assess DA striatal binding. Mice were divided into 4 groups, according to different treatments: group 1 (control), group 2 (ALC, 100 mg/kg), group 3 (METH, 10 mg/kg) and group 4 (ALC+METH). Images were acquired in a SPECT/CT scanner (NanoSPECT/CT, Mediso, Hungary) 70 minutes after 123I‐IBZM injection. Regions of interest were drawn in the striata and in the cerebellum to determine the striatal binding ratio. Increased intracellular levels of DA were observed in PC12 cells at 24h and 72h after the administration of ALC. Cells treated with METH 100 µM displayed decreased intracellular levels of DA. ALC prevented the METH‐induced decrease in DA concentration (p<0.0001). On the other hand, a single dose of 10 mg/kg of METH induced a decrease in striatal D2R binding ratios comparing to control group (between 20% and 30%). Interestingly, over time, ALC was able to reverse the decrease on the radiotracer binding induced by METH. The present study indicates a possible effect of ALC over METH‐induced DA release.info:eu-repo/semantics/publishedVersio

New Converter Solution with a Compact Modular Multilevel Structure Suitable for High-Power Medium-Voltage Wind Turbines

Modern wind turbines with increasing power levels are continuously emerging. These power levels are reaching a point where excessively high currents are obtained if the traditional low-voltage wind-turbine structure is adopted. High currents lead to excessively high losses and the need for bulky and heavy conductors to carry them. A medium-voltage structure should be a more competitive alternative to be adopted in high-power wind turbines. In this paper, a new converter solution with a modular multilevel structure suitable for driving modern/future high-power medium-voltage wind turbines is proposed. This converter topology has desirable features common to modular multilevel converters such as the improved reliability at high voltage levels, and the possibility to synthesize high-power-quality staircase-shape voltages, which leads to low requirements for harmonic and $\frac{dv}{dt}$ filters. Furthermore, the proposed converter presents reduced capacitance and inductance requirements compared to other well-established modular multilevel converter topologies, which should result in a lighter and more compact solution. The proposed solution could potentially allow for the reduction of the overall costs of the supporting structure required to withstand the weight of the wind turbine. Simulation and experimental results are presented in this paper to validate the proposed topology

Dispatchable High-Power Wind Turbine Based on a Multilevel Converter with Modular Structure and Hybrid Energy Storage Integration

This paper presents a new multilevel converter solution with modular structure and hybrid energy-storage integration suitable to drive modern/future high-power medium-voltage wind turbines. The hybrid energy-storage integration means that part of the converter submodules are built with batteries and part of them with conventional capacitors. Since traditional wind turbines are non-dispatchable generators, the integration of an energy storage system could be beneficial in multiple ways as the wind power plant could provide stability support to the grid, improvement of the unit commitment and economic dispatch, and the power plant owner could increase his revenues in the electricity market. The capacitors of the proposed converter are responsible to transfer the power produced by the wind turbine to the grid, and the batteries are only charged/discharged with the mismatch between the power produced by the turbine and the power to be injected into the grid, considering a dispatchable operation where the power injected into the grid is different from the power generated by the turbine. The medium-voltage structure could be an interesting option to overcome problems related to high currents in modern/future high-power wind turbines resulting in more efficient, more compact and lighter solutions. Modular multilevel converters are suitable to handle medium-voltage levels and they allow for a straightforward integration of energy storage systems in a decentralized manner

Dietary Patterns Prior to Pregnancy and Associations with Pregnancy Complications

Few studies have explored pre-pregnancy diet and its relationship with pregnancy outcomes. The objectives of this study were to: (1) derive pre-pregnancy dietary patterns for women enrolled in a prospective cohort in the province of Alberta, Canada; (2) describe associations between dietary patterns and socio-demographic characteristics; and (3) describe associations between dietary patterns and pregnancy complications. Upon enrolment into the Alberta Pregnancy Outcomes and Nutrition (APrON) study (median age of gestation, 17 weeks), women (n = 1545) completed a validated 142-item food frequency questionnaire recording food and beverages consumed "in the 12 months prior to pregnancy". Other assessments included pre-pregnancy body mass index (BMI), gestational weight gain, gestational hypertension, gestational diabetes, and socio-demographic characteristics. Dietary patterns were derived using principal components analysis. Scores were calculated to represent adherence with each dietary pattern retained. Four dietary patterns were retained, accounting for 22.9% of the variation in the overall diet. Dietary patterns were named the "healthy", "meat and refined carbohydrate", "beans, cheese and salad" or "tea and coffee" patterns. Higher "healthy" pattern scores prior to pregnancy were associated with lower odds of developing gestational hypertension during pregnancy (adjusted Odds Ratio (OR): 0.6, 95% Confidence Intervals (CI): 0.4, 0.9). Diet prior to pregnancy is an important target for interventions and may reduce the likelihood of developing complications such as gestational hypertension during pregnancy

Engineering tyrosine residues into hemoglobin enhances heme reduction, decreases oxidative stress and increases vascular retention of a hemoglobin based blood substitute

Hemoglobin (Hb)-based oxygen carriers (HBOC) are modified extracellular proteins, designed to replace or augment the oxygen-carrying capacity of erythrocytes. However, clinical results have generally been disappointing due to adverse side effects, in part linked to the intrinsic oxidative toxicity of Hb. Previously a redox-active tyrosine residue was engineered into the Hb β subunit (βF41Y) to facilitate electron transfer between endogenous antioxidants such as ascorbate and the oxidative ferryl heme species, converting the highly oxidizing ferryl species into the less reactive ferric (met) form. We inserted different single tyrosine mutations into the α and β subunits of Hb to determine if this effect of βF41Y was unique. Every mutation that was inserted within electron transfer range of the protein surface and the heme increased the rate of ferryl reduction. However, surprisingly, three of the mutations (βT84Y, αL91Y and βF85Y) also increased the rate of ascorbate reduction of ferric(met) Hb to ferrous(oxy) Hb. The rate enhancement was most evident at ascorbate concentrations equivalent to that found in plasma (< 100 μM), suggesting that it might be of benefit in decreasing oxidative stress in vivo. The most promising mutant (βT84Y) was stable with no increase in autoxidation or heme loss. A decrease in membrane damage following Hb addition to HEK cells correlated with the ability of βT84Y to maintain the protein in its oxygenated form. When PEGylated and injected into mice, βT84Y was shown to have an increased vascular half time compared to wild type PEGylated Hb. βT84Y represents a new class of mutations with the ability to enhance reduction of both ferryl and ferric Hb, and thus has potential to decrease adverse side effects as one component of a final HBOC product

Rationale, design and conduct of a randomised controlled trial evaluating a primary care-based complex intervention to improve the quality of life of heart failure patients: HICMan (Heidelberg Integrated Case Management) : study protocol

Background: Chronic congestive heart failure (CHF) is a complex disease with rising prevalence, compromised quality of life (QoL), unplanned hospital admissions, high mortality and therefore high burden of illness. The delivery of care for these patients has been criticized and new strategies addressing crucial domains of care have been shown to be effective on patients' health outcomes, although these trials were conducted in secondary care or in highly organised Health Maintenance Organisations. It remains unclear whether a comprehensive primary care-based case management for the treating general practitioner (GP) can improve patients' QoL. Methods/Design: HICMan is a randomised controlled trial with patients as the unit of randomisation. Aim is to evaluate a structured, standardized and comprehensive complex intervention for patients with CHF in a 12-months follow-up trial. Patients from intervention group receive specific patient leaflets and documentation booklets as well as regular monitoring and screening by a prior trained practice nurse, who gives feedback to the GP upon urgency. Monitoring and screening address aspects of disease-specific selfmanagement, (non)pharmacological adherence and psychosomatic and geriatric comorbidity. GPs are invited to provide a tailored structured counselling 4 times during the trial and receive an additional feedback on pharmacotherapy relevant to prognosis (data of baseline documentation). Patients from control group receive usual care by their GPs, who were introduced to guidelineoriented management and a tailored health counselling concept. Main outcome measurement for patients' QoL is the scale physical functioning of the SF-36 health questionnaire in a 12-month follow-up. Secondary outcomes are the disease specific QoL measured by the Kansas City Cardiomyopathy questionnaire (KCCQ), depression and anxiety disorders (PHQ-9, GAD-7), adherence (EHFScBS and SANA), quality of care measured by an adapted version of the Patient Chronic Illness Assessment of Care questionnaire (PACIC) and NTproBNP. In addition, comprehensive clinical data are collected about health status, comorbidity, medication and health care utilisation. Discussion: As the targeted patient group is mostly cared for and treated by GPs, a comprehensive primary care-based guideline implementation including somatic, psychosomatic and organisational aspects of the delivery of care (HICMAn) is a promising intervention applying proven strategies for optimal care. Trial registration: Current Controlled Trials ISRCTN30822978