SK2 channels are required for function and long-term survival of efferent synapses on mammalian outer hair cells

Cochlear hair cells use SK2 currents to shape responses to cholinergic efferent feedback from the brain. Using SK2-/- mice, we demonstrate that, in addition to their previously defined role in modulating hair cell membrane potentials, SK2 channels are necessary for long-term survival of olivocochlear fibers and synapses. Loss of the SK2 gene also results in loss of electrically driven olivocochlear effects in vivo, and down regulation of ryanodine receptors involved in calcium-induced calcium release, the main inducer of nAChR evoked SK2 activity. Generation of double-null mice lacking both the α10 nAChR gene, loss of which results in hypertrophied olivocochlear terminals, and the SK2 gene, recapitulates the SK2-/- synaptic phenotype and gene expression, and also leads to down regulation of α9 nAChR gene expression. The data suggest a hierarchy of activity necessary to maintain early olivocochlear synapses at their targets, with SK2 serving an epistatic, upstream, role to the nAChRs.Fil: Murthy, Vidya. Tufts University; Estados UnidosFil: Maison, Stéphane F.. Massachusetts Eye and Ear Infirmary; Estados Unidos. Harvard Medical School; Estados UnidosFil: Taranda, Julian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Tufts University; Estados UnidosFil: Haque, Nadeem. University of Notre Dame; Estados UnidosFil: Bond, Chris T.. Oregon Health Sciences University; Estados UnidosFil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Adelman, John P.. Oregon Health Sciences University; Estados UnidosFil: Liberman, M. Charles. Massachusetts Eye and Ear Infirmary; Estados Unidos. Harvard Medical School; Estados UnidosFil: Vetter, Douglas E.. Tufts University; Estados Unido

Critical phenomena in Newtonian gravity

We investigate the stability of self-similar solutions for a gravitationally collapsing isothermal sphere in Newtonian gravity by means of a normal mode analysis. It is found that the Hunter series of solutions are highly unstable, while neither the Larson-Penston solution nor the homogeneous collapse one have an analytic unstable mode. Since the homogeneous collapse solution is known to suffer the kink instability, the present result and recent numerical simulations strongly support a proposition that the Larson-Penston solution will be realized in astrophysical situations. It is also found that the Hunter (A) solution has a single unstable mode, which implies that it is a critical solution associated with some critical phenomena which are analogous to those in general relativity. The critical exponent $\gamma$ is calculated as $\gamma\simeq 0.10567$. In contrast to the general relativistic case, the order parameter will be the collapsed mass. In order to obtain a complete picture of the Newtonian critical phenomena, full numerical simulations will be needed.Comment: 25 pages, 7 figures, accepted for publication in Physical Review

Harrison transformation of hyperelliptic solutions and charged dust disks

We use a Harrison transformation on solutions to the stationary axisymmetric Einstein equations to generate solutions of the Einstein-Maxwell equations. The case of hyperelliptic solutions to the Ernst equation is studied in detail. Analytic expressions for the metric and the multipole moments are obtained. As an example we consider the transformation of a family of counter-rotating dust disks. The resulting solutions can be interpreted as disks with currents and matter with a purely azimuthal pressure or as two streams of freely moving charged particles. We discuss interesting limiting cases as the extreme limit where the charge becomes identical to the mass, and the ultrarelativistic limit where the central redshift diverges.Comment: 20 pages, 9 figure

On critical behaviour in gravitational collapse

We give an approach to studying the critical behaviour that has been observed in numerical studies of gravitational collapse. These studies suggest, among other things, that black holes initially form with infinitesimal mass. We show generally how a black hole mass formula can be extracted from a transcendental equation. Using our approach, we give an explicit one parameter set of metrics that are asymptotically flat and describe the collapse of apriori unspecified but physical matter fields. The black hole mass formula obtained from this metric exhibits a mass gap - that is, at the onset of black hole formation, the mass is finite and non-zero.Comment: 11 pages, RevTex, 2 figures (available from VH

Polar Perturbations of Self-gravitating Supermassive Global Monopoles

Spontaneous global symmetry breaking of O(3) scalar field gives rise to point-like topological defects, global monopoles. By taking into account self-gravity,the qualitative feature of the global monopole solutions depends on the vacuum expectation value v of the scalar field. When v < sqrt{1 / 8 pi}, there are global monopole solutions which have a deficit solid angle defined at infinity. When sqrt{1 / 8 pi} <= v < sqrt{3 / 8 pi}, there are global monopole solutions with the cosmological horizon, which we call the supermassive global monopole. When v >= sqrt{3 / 8 pi}, there is no nontrivial solution. It was shown that all of these solutions are stable against the spherical perturbations. In addition to the global monopole solutions, the de Sitter solutions exist for any value of v. They are stable against the spherical perturbations when v sqrt{3 / 8 pi}. We study polar perturbations of these solutions and find that all self-gravitating global monopoles are stable even against polar perturbations, independently of the existence of the cosmological horizon, while the de Sitter solutions are always unstable.Comment: 10 pages, 6 figures, corrected some type mistakes (already corrected in PRD version

Criticality and convergence in Newtonian collapse

We study through numerical simulation the spherical collapse of isothermal gas in Newtonian gravity. We observe a critical behavior which occurs at the threshold of gravitational instability leading to core formation. For a given initial density profile, we find a critical temperature, which is of the same order as the virial temperature of the initial configuration. For the exact critical temperature, the collapse converges to a self-similar form, the first member in Hunter's family of self-similar solutions. For a temperature close to the critical value, the collapse first approaches this critical solution. Later on, in the supercritical case, the collapse converges to another self-similar solution, which is called the Larson-Penston solution. In the subcritical case, the gas bounces and disperses to infinity. We find two scaling laws: one for the collapsed mass in the supercritical case and the other for the maximum density reached before dispersal in the subcritical case. The value of the critical exponent is measured to be $\simeq 0.11$ in the supercritical case, which agrees well with the predicted value $\simeq 0.10567$. These critical properties are quite similar to those observed in the collapse of a radiation fluid in general relativity. We study the response of the system to temperature fluctuation and discuss astrophysical implications for the insterstellar medium structure and for the star formation process. Newtonian critical behavior is important not only because it provides a simple model for general relativity but also because it is relevant for astrophysical systems such as molecular clouds.Comment: 15 pages, 8 figures, accepted for publication in PRD, figures 1 and 3 at lower resolution than in journal version, typos correcte

Black Hole Critical Phenomena Without Black Holes

Studying the threshold of black hole formation via numerical evolution has led to the discovery of fascinating nonlinear phenomena. Power-law mass scaling, aspects of universality, and self-similarity have now been found for a large variety of models. However, questions remain. Here I briefly review critical phenomena, discuss some recent results, and describe a model which demonstrates similar phenomena without gravity.Comment: 13 pages, 6 figures; Submission for the proceedings of ICGC 2000 in the journal Preman

Perturbations and Critical Behavior in the Self-Similar Gravitational Collapse of a Massless Scalar Field

This paper studies the perturbations of the continuously self-similar critical solution of the gravitational collapse of a massless scalar field (Roberts solution). The perturbation equations are derived and solved exactly. The perturbation spectrum is found to be not discrete, but occupying continuous region of the complex plane. The renormalization group calculation gives the value of the mass-scaling exponent equal to 1.Comment: 12 pages, RevTeX 3.1, 1 figur

Bound monopoles in Brans-Dicke theory

We consider axially symmetric SU(2) Yang-Mills-Higgs (YMH) multimonopoles in Brans-Dicke theory for winding number n > 1. In analogy to the spherically symmetric n=1 solutions, we find that the axially symmetric solutions exist for higher values of the gravitational coupling than in the pure Einstein gravity case. For large values of the gravitational coupling, the solutions collapse to form a black hole which outside the horizon can be described by an extremal Reissner-Nordstrom solution. Similarly as in the pure Einstein gravity case, like-charged monopoles reside in an attractive phase in a limited domain of parameter space. However, we find that the strength of attraction is decreasing for decreasing Brans-Dicke parameter.Comment: 9 Revtex pages + 4 ps-figures; reference added, conclusions extende