Hazards to space workers from ionizing radiation

A compilation of background information and a preliminary assessment of the potential risks to workers from the ionizing radiation encountered in space is provided. The report: (1) summarizes the current knowledge of the space radiation environment to which space workers will be exposed; (2) reviews the biological effects of ionizing radiation considered of major importance to a SPS project; and (3) discusses the health implications of exposure of populations of space workers to the radiations likely to penetrate through the shielding provided by the SPS work stations and habitat shelters of the SPS Reference System

Observations by human subjects on radiation- induced light flashes in fast-neutron, X-ray, and positive-pion beams

Exposure of human subjects to fast neutron beam to determine cause of light flashes observed by astronauts on lunar mission

Human visual response to nuclear particle exposures

Experiments with accelerated helium ions were performed in an effort to localize the site of initial radiation interactions in the eye that lead to light flash observations by astronauts during spaceflight. The character and efficiency of helium ion induction of visual sensations depended on the state of dark adaptation of the retina; also, the same events were seen with different efficiencies and details when particle flux density changed. It was concluded that fast particles cause interactions in the retina, particularly in the receptor layer, and thus give rise to the sensations of light flashes, streaks, and supernovae

Documents relating to the Ursuline Convent in Charlestown

An 1842 reprint containing two reports detailing the events surrounding the 1834 mob destruction of the Ursuline Convent in Charlestown, MA. The first report discusses the public responsibility and duty of the State to protect its citizens and their property, regardless of social or religious affiliation, from unjust actions. The second report, produced by a select committee of the Massachusetts House of Representatives, discusses the merits of a petition for the Commonwealth to indemnify the Sisters of the Ursuline Order for their loss. Boston: Reprinted by Samuel N. Dickinson, 1842. See The Trial of John R. Buzzell by Lemuel Shaw, LL.D, published at the time of the incident (1834) for a detailed account of the mob destruction of the Convent and the subsequent trial of Buzzell and his fellow co-conspirators

Boost regulator design and development

Design criteria for pulse and frequency modulated boost regulato

Compaction and Chemical Grouting for Drain Tunnels in Phoenix

Ground runs during ml.m.ng of the Papago Freeway Drain Tunnels posed significant potential risk to utilities, street pavement, and buildings located above and adjacent to one of the three tunnel alignments. Ground response to the larger ground runs resulted in open chimneys and settlement of the ground surface of up to several feet. Modifications to the tunneling machine included addition of poling plates and breasting boards. Further modification to the tunneling method included use of compaction grouting in conjunction with mining for the entire length of one tunnel alignment, and use of chemical grouting to prestabilize the ground surrounding the tunnel opening in areas of high risk utilities and in areas where subsurface conditions suggested that running ground would be encountered during mining. This paper presents a summary of the ground behavior with and without the compaction and chemical grouting and describes the grouting methods

Ski Promotes Tumor Growth Through Abrogation of Transforming Growth Factor-?? Signaling in Pancreatic Cancer

Objective: We hypothesized that human pancreatic cancer resists TGF-β signaling and cell death through increased Ski expression. Summary Background Data: Ski is an oncogenic protein that acts as a TGF-β repressor and prevents related gene transcription. Previous work suggests that Ski acts as an oncoprotein in melanoma and esophageal cancer. Ski expression and function have not been determined in human pancreatic cancer. Methods: Immunohistochemistry and immunoblots assessed Ski expression in human pancreatic cancer. Panc-1 cells were treated with or without Ski siRNA, and Ski and Smad protein expression, transcriptional reporter activation, and growth assays were determined. Panc-1 cells were inoculated in the flank of nude mice and tumor volume and histology assessed after administration of Ski siRNA or control vector. Results: Ski was abundantly expressed in human pancreatic cancer specimens assessed by immunohistochemistry (91%) and immunoblot analysis (67%). Panc-1 cells exhibited nascent Ski expression that was maximally inhibited 48 hours after transfection with Ski siRNA. TGF-β transcriptional activity was increased 2.5-fold in Ski siRNA-treated cells compared with control (P < 0.05). Ski siRNA increased TGF-β-induced Smad2 phosphorylation and p21 expression. Panc-1 growth in culture was decreased 2-fold at 72 hours. A Ski siRNA expression vector injected into nude mice resulted in a 5-fold decrease in growth. Conclusion: Inhibition of Ski through RNA interference restored TGF-β signaling and growth inhibition in vitro, and decreased tumor growth in vivo

Galactic emission at 19 GHz

We cross-correlate a 19 GHz full sky Cosmic Microwave Background (CMB) survey with other maps to quantify the foreground contribution. Correlations are detected with the Diffuse Infrared Background Experiment (DIRBE) 240, 140 and 100 micron maps at high latitudes (|b|>30degrees), and marginal correlations are detected with the Haslam 408 MHz and the Reich & Reich 1420 MHz synchrotron maps. The former agree well with extrapolations from higher frequencies probed by the COBE DMR and Saskatoon experiments and are consistent with both free-free and rotating dust grain emission.Comment: 4 pages, with 4 figures included. Accepted for publication in ApJL. Color figure and links at http://www.sns.ias.edu/~angelica/foreground.html#19 or from [email protected]