BATSE Gamma-Ray Burst Line Search: V. Probability of Detecting a Line in a Burst

The physical importance of the apparent discrepancy between the detections by pre-BATSE missions of absorption lines in gamma-ray burst spectra and the absence of a BATSE line detection necessitates a statistical analysis of this discrepancy. This analysis requires a calculation of the probability that a line, if present, will be detected in a given burst. However, the connection between the detectability of a line in a spectrum and in a burst requires a model for the occurrence of a line within a burst. We have developed the necessary weighting for the line detection probability for each spectrum spanning the burst. The resulting calculations require a description of each spectrum in the BATSE database. With these tools we identify the bursts in which lines are most likely to be detected. Also, by assuming a small frequency with which lines occur, we calculate the approximate number of BATSE bursts in which lines of various types could be detected. Lines similar to the Ginga detections can be detected in relatively few BATSE bursts; for example, in only ~20 bursts are lines similar to the GB 880205 pair of lines detectable. Ginga reported lines at ~20 and ~40 keV whereas the low energy cutoff of the BATSE spectra is typically above 20 keV; hence BATSE's sensitivity to lines is less than that of Ginga below 40 keV, and greater above. Therefore the probability that the GB 880205 lines would be detected in a Ginga burst rather than a BATSE burst is ~0.2. Finally, we adopted a more appropriate test of the significance of a line feature.Comment: 20 pages, AASTeX 4.0, 5 figures, Ap.J. in pres

The cessation in pregnancy incentives trial (CPIT): study protocol for a randomized controlled trial

Background: Seventy percent of women in Scotland have at least one baby, making pregnancy an opportunity to help most young women quit smoking before their own health is irreparably compromised. By quitting during pregnancy their infants will be protected from miscarriage and still birth as well as low birth weight, asthma, attention deficit disorder and adult cardiovascular disease. In the UK, the NICE guidelines: 'How to stop smoking in pregnancy and following childbirth' (June 2010) highlighted that little evidence exists in the literature to confirm the efficacy of financial incentives to help pregnant smokers to quit. Its first research recommendation was to determine: Within a UK context, are incentives an acceptable, effective and cost-effective way to help pregnant women who smoke to quit? <p/>Design and Methods: This study is a phase II exploratory individually randomised controlled trial comparing standard care for pregnant smokers with standard care plus the additional offer of financial voucher incentives to engage with specialist cessation services and/or to quit smoking during pregnancy. Participants (n=600) will be pregnant smokers identified at maternity booking who when contacted by specialist cessation services agree to having their details passed to the NHS Smokefree Pregnancy Study Helpline to discuss the trial. The NHS Smokefree Pregnancy Study Helpline will be responsible for telephone consent and follow-up in late pregnancy. The primary outcome will be self reported smoking in late pregnancy verified by cotinine measurement. An economic evaluation will refine cost data collection and assess potential cost-effectiveness while qualitative research interviews with clients and health professionals will assess the level of acceptance of this form of incentive payment. Research questions What is the likely therapeutic efficacy? Are incentives potentially cost-effective? Is individual randomisation an efficient trial design without introducing outcome bias? Can incentives be introduced in a way that is feasible and acceptable? <p/>Discussion: This phase II trial will establish a workable design to reduce the risks associated with a future definitive phase III multicentre randomised controlled trial and establish a framework to assess the costs and benefits of financial incentives to help pregnant smokers to quit

Functional porous composites by blending with solution-processable molecular pores

Porous scrambled cages can be homogenously blended with both functional molecules and non-porous polymers to form functional porous composites materials.</p

A novel multigrid method for electronic structure calculations

A general real-space multigrid algorithm for the self-consistent solution of the Kohn-Sham equations appearing in the state-of-the-art electronic-structure calculations is described. The most important part of the method is the multigrid solver for the Schroedinger equation. Our choice is the Rayleigh quotient multigrid method (RQMG), which applies directly to the minimization of the Rayleigh quotient on the finest level. Very coarse correction grids can be used, because there is no need to be able to represent the states on the coarse levels. The RQMG method is generalized for the simultaneous solution of all the states of the system using a penalty functional to keep the states orthogonal. The performance of the scheme is demonstrated by applying it in a few molecular and solid-state systems described by non-local norm-conserving pseudopotentials.Comment: 9 pages, 3 figure

Timesaving Double-Grid Method for Real-Space Electronic-Structure Calculations

We present a simple and efficient technique in ab initio electronic-structure calculation utilizing real-space double-grid with a high density of grid points in the vicinity of nuclei. This technique promises to greatly reduce the overhead for performing the integrals that involves non-local parts of pseudopotentials, with keeping a high degree of accuracy. Our procedure gives rise to no Pulay forces, unlike other real-space methods using adaptive coordinates. Moreover, we demonstrate the potential power of the method by calculating several properties of atoms and molecules.Comment: 4 pages, 5 figure

Development of transparent microwell arrays for optical monitoring and dissection of microbial communities

Citation: Halsted, M., Wilmoth, J. L., Briggs, P. A., Hansen, R. R., Briggs, D. P., Timm, A. C., & Retterer, S. T. (2016). Development of transparent microwell arrays for optical monitoring and dissection of microbial communities. Journal of Vacuum Science & Technology B, 34(6), 5. doi:10.1116/1.4962739Microbial communities are incredibly complex systems that dramatically and ubiquitously influence our lives. They help to shape our climate and environment, impact agriculture, drive business, and have a tremendous bearing on healthcare and physical security. Spatial confinement, as well as local variations in physical and chemical properties, affects development and interactions within microbial communities that occupy critical niches in the environment. Recent work has demonstrated the use of silicon based microwell arrays, combined with parylene lift-off techniques, to perform both deterministic and stochastic assembly of microbial communities en masse, enabling the high-throughput screening of microbial communities for their response to growth in confined environments under different conditions. The implementation of a transparent microwell array platform can expand and improve the imaging modalities that can be used to characterize these assembled communities. Here, the fabrication and characterization of a next generation transparent microwell array is described. The transparent arrays, comprised of SU-8 patterned on a glass coverslip, retain the ability to use parylene lift-off by integrating a low temperature atomic layer deposition of silicon dioxide into the fabrication process. This silicon dioxide layer prevents adhesion of the parylene material to the patterned SU-8, facilitating dry lift-off, and maintaining the ability to easily assemble microbial communities within the microwells. These transparent microwell arrays can screen numerous community compositions using continuous, high resolution, imaging. The utility of the design was successfully demonstrated through the stochastic seeding and imaging of green fluorescent protein expressing Escherichia coli using both fluorescence and brightfield microscopies. (C) 2016 American Vacuum Society

Constraints on changes in fundamental constants from a cosmologically distant OH absorber/emitter

We have detected the four 18cm OH lines from the $z \sim 0.765$ gravitational lens toward PMN J0134-0931. The 1612 and 1720 MHz lines are in conjugate absorption and emission, providing a laboratory to test the evolution of fundamental constants over a large lookback time. We compare the HI and OH main line absorption redshifts of the different components in the $z \sim 0.765$ absorber and the $z \sim 0.685$ lens toward B0218+357 to place stringent constraints on changes in $F \equiv g_p [\alpha^2/\mu]^{1.57}$. We obtain $[\Delta F/F] = (0.44 \pm 0.36^{\rm stat} \pm 1.0^{\rm syst}) \times 10^{-5}$, consistent with no evolution over the redshift range $0 < z < 0.7$. The measurements have a $2 \sigma$ sensitivity of $[\Delta \alpha/\alpha] < 6.7 \times 10^{-6}$ or $[\Delta \mu/\mu] < 1.4 \times 10^{-5}$ to fractional changes in $\alpha$ and $\mu$ over a period of $\sim 6.5$ Gyr, half the age of the Universe. These are among the most sensitive current constraints on changes in $\mu$.Comment: 4 pages, 3 figures. Final version, with minor changes to match the version in print in Phys. Rev. Let