Birth Preparedness and Complication Readiness of Pregnant Women Attending the Three Levels of Health Facilities in Ife Central Local Government, Nigeria

Background: Birth preparedness and complication readiness (BP/CR) is a safe motherhood strategy which addresses delays that could increase the risk of dying in pregnancy, child birth and the immediate postpartum period. The strategy has not been effectively implemented in Nigeria hence maternal mortality remains unacceptably high. This study assessed the level of BP/CR and the determinants among antenatal clinic attendees in Ife Central Local Government Area of Nigeria. Subjects and Method: Antenatal women selected proportional to client caseloads from health facilities were studied using a semi-structured questionnaire. SPSS version 16 was used for data entry. Univariate, bivariate and multivariate analyses were performed. Results: Four hundred and one antenatal women were recruited. One hundred and fifty eight (39.3%) respondents knew no danger sign in pregnancy, childbirth and postpartum period. Only 24 (6.0%) had adequate knowledge of obstetric danger signs without prompting. Three hundred and forty (84.8%) and 312 (78.3%) women respectively had identified a birth place and begun saving money for delivery. As many as 304 (79.4%) made no arrangement for a blood donor. Majority of pregnant women (60-82%) took five other steps towards emergency readiness. By the study criteria, 140 (34.9%) and 265 (66.1%) were birth and complication prepared respectively. Conclusion: Majority of pregnant women had poor knowledge of obstetric danger signs. Women who booked late were moreJournal of Community Medicine & Primary Health vol 23 (1-2) 201

ISOLATION, CHARACTERIZATION AND IMMUNOCHEMICAL STUDIES ON FIBROUS PROTEINS FROM COWRY SHELL (CYPRAEA MONETA, LINNAEUS)

Background: Biomaterials are non-drug substances used to treat, enhance or replace functions of body tissues or organs. Natural sources of biomaterials have recently become the focus of several research activities. Cowry shell constitutes one of the most promising natural sources of biomaterials because of its chemical stability, biodegradability and biocompatibility in the body. However, its applications may be limited due to immunogenic and toxic responses that may occur following implantation, hence this study. Materials and Methods: Crude fibrous protein extracted with citrate buffer from pulverised cowry shells (Cypraea moneta (L)), was resolved into two components (CSP1 and CSP2) by gel filtration. Immunological studies were performed with antisera obtained from rabbits by double immunodiffusion and immunoelectrophoresis techniques. Mice treated with the proteins were observed for signs of toxicity and their liver, kidney, lungs and spleen were processed histologically. Results: The native molecular weight of CSP1 and CSP2 determined by gel filtration were 91kDa and 33kDa respectively. CSP1 and CSP2 displayed single bands on SDS-PAGE with subunit molecular weight values of 19kDa and 19.5kDa respectively. Antisera obtained from rabbits immunised with the crude citrate buffer extracts precipitated the antigen in double immunodiffusion tests. Histopathological examinations revealed a dose-dependent damaging effect of the shell proteins on liver, kidney, lung and spleen tissues of the treated mice. Conclusion: This study showed that cowry shells contain fibrous proteins which are immunogenic and toxic in mice at relatively high concentrations, causing visible organ damage without concurrent physical manifestations

TRH: Pathophysiologic and clinical implications

Thyrotropin releasing hormone is thought to be a tonic stimulator of the pituitary TSH secretion regulating the setpoint of the thyrotrophs to the suppressive effect of thyroid hormones. The peptide stimulates the release of normal and elevated prolactin. ACTH and GH may increase in response to exogenous TRH in pituitary ACTH and GH hypersecretion syndromes and in some extrapituitary diseases. The pathophysiological implications of extrahypothalamic TRH in humans are essentially unknown. The TSH response to TRH is nowadays widely used as a diganostic amplifier in thyroid diseases being suppressed in borderline and overt hyperthyroid states and increased in primary thyroid failure. In hypothyroid states of hypothalamic origin, TSH increases in response to exogenous TRH often with a delayed and/or exaggerated time course. But in patients with pituitary tumors and suprasellar extension TSH may also respond to TRH despite secondary hypothyroidism. This TSH increase may indicate a suprasellar cause for the secondary hypothyroidism, probably due to portal vessel occlusion. The TSH released in these cases is shown to be biologically inactive

Prophylactic human papillomavirus vaccination against cervical cancer : a summarised resource for clinicians

No abstract available.http://www.sajgo.co.za/index.php/sajg

Pica associated with iron deficiency or depletion: clinical and laboratory correlates in 262 non-pregnant adult outpatients

<p>Abstract</p> <p>Background</p> <p>There are many descriptions of the association of pica with iron deficiency in adults, but there are few reports in which observations available at diagnosis of iron deficiency were analyzed using multivariable techniques to identify significant predictors of pica. We sought to identify clinical and laboratory correlates of pica in adults with iron deficiency or depletion using univariable and stepwise forward logistic regression analyses.</p> <p>Methods</p> <p>We reviewed charts of 262 non-pregnant adult outpatients (ages ≥18 y) who required treatment with intravenous iron dextran. We tabulated their sex, age, race/ethnicity, body mass index, symptoms and causes of iron deficiency or depletion, serum iron and complete blood count measures, and other conditions at diagnosis before intravenous iron dextran was administered. We excluded patients with serum creatinine >133 μmol/L or disorders that could affect erythrocyte or iron measures. Iron deficiency was defined as both SF <45 pmol/L and TS <10%. Iron depletion was defined as serum ferritin (SF) <112 pmol/L. We performed univariable comparisons and stepwise forward logistic regression analyses to identify significant correlates of pica.</p> <p>Results</p> <p>There were 230 women (184 white, 46 black; ages 19-91 y) and 32 men (31 white, 1 black; ages 24-81 y). 118 patients (45.0%) reported pica; of these, 87.3% reported ice pica (pagophagia). In univariable analyses, patients with pica had lower mean age, black race/ethnicity, and higher prevalences of cardiopulmonary and epithelial manifestations. The prevalence of iron deficiency, with or without anemia, did not differ significantly between patients with and without pica reports. Mean hemoglobin and mean corpuscular volume (MCV) were lower and mean red blood cell distribution width (RDW) and platelet count were higher in patients with pica. Thrombocytosis occurred only in women and was more prevalent in those with pica (20.4% vs. 8.3%; p = 0.0050). Mean total iron-binding capacity was higher and mean serum ferritin was lower in patients with pica. Nineteen patients developed a second episode of iron deficiency or depletion; concordance of recurrent pica (or absence of pica) was 95%. Predictors of pica in logistic regression analyses were age and MCV (negative associations; p = 0.0250 and 0.0018, respectively) and RDW and platelet count (positive associations; p = 0.0009 and 0.02215, respectively); the odds ratios of these predictors were low.</p> <p>Conclusions</p> <p>In non-pregnant adult patients with iron deficiency or depletion, lower age is a significant predictor of pica. Patients with pica have lower MCV, higher RDW, and higher platelet counts than patients without pica.</p

Crystallization of CdTe Thin Films by CdCl2 Treatment at High Temperature

CdTe thin films deposited by evaporation on a Cu-Mo covered glass substrate have been treated vithCdCl2 at a temperature of 400-600°C in an argon flow. The dependence of the CdTe thin film grain size on CdCl2 thickness, substrate temperature and argon flux has been studied. By controlling these parameters, CdTe films with a grain size larger than 20 μm can be reproducibly obtained. CdTe/CdS back-wall thin film solar cell prepared by using the CdCl2-treated CdTe films exhibit conversion efficiency larger than 10%

Social Capital and Welfare among Farming Households in Ekiti State, Nigeria

The study examined the effects of social capital on household welfare in Ekiti State, Nigeria. The data for the study was collected from 186 households in three local government areas (LGAs) of the state using random sampling techniques. Data analysis was done using descriptive statistics, social capital indices and regression technique. Average age of the household heads stood at 54.4 years with 7 years of formal education. Household size was 7 members with monthly per capital income of N38,801.56. About 18% of per capita expenditure was spent on food. Households attended two out of every three meetings and had high level of active participation in decision making of 77%. The index of heterogeneity at 23.7  indicated low level of diversity of the associations. Monthly cash contribution was highest for members in cooperative associations followed by religious association. A one unit increase in the level of social capital would increase household per capita expenditure by 0.31%. Disaggregation of social capital into its components showed that its effect on welfare was traceable to cash contribution and decision making of households in associations. Social capital was truly exogenous to household’s welfare with no reverse causality. The study concluded that social capital positively affected household welfare. Keywords: Social Capital, Welfare, Heterogeneity Index, Exogeneity, Ekiti Stat