458 research outputs found
Exploring the Function of Neural Oscillations in Early Sensory Systems
Neuronal oscillations appear throughout the nervous system, in structures as diverse as the cerebral cortex, hippocampus, subcortical nuclei and sense organs. Whether neural rhythms contribute to normal function, are merely epiphenomena, or even interfere with physiological processing are topics of vigorous debate. Sensory pathways are ideal for investigation of oscillatory activity because their inputs can be defined. Thus, we will focus on sensory systems as we ask how neural oscillations arise and how they might encode information about the stimulus. We will highlight recent work in the early visual pathway that shows how oscillations can multiplex different types of signals to increase the amount of information that spike trains encode and transmit. Last, we will describe oscillation-based models of visual processing and explore how they might guide further research
Retinal oscillations carry visual information to cortex
Thalamic relay cells fire action potentials that transmit information from
retina to cortex. The amount of information that spike trains encode is usually
estimated from the precision of spike timing with respect to the stimulus.
Sensory input, however, is only one factor that influences neural activity. For
example, intrinsic dynamics, such as oscillations of networks of neurons, also
modulate firing pattern. Here, we asked if retinal oscillations might help to
convey information to neurons downstream. Specifically, we made whole-cell
recordings from relay cells to reveal retinal inputs (EPSPs) and thalamic
outputs (spikes) and analyzed these events with information theory. Our results
show that thalamic spike trains operate as two multiplexed channels. One
channel, which occupies a low frequency band (<30 Hz), is encoded by average
firing rate with respect to the stimulus and carries information about local
changes in the image over time. The other operates in the gamma frequency band
(40-80 Hz) and is encoded by spike time relative to the retinal oscillations.
Because these oscillations involve extensive areas of the retina, it is likely
that the second channel transmits information about global features of the
visual scene. At times, the second channel conveyed even more information than
the first.Comment: 21 pages, 10 figures, submitted to Frontiers in Systems Neuroscienc
Effects of experience and commercialisation on survival in Himalayan mountaineering: retrospective cohort study
Objectives To determine whether previous Himalayan experience is associated with a decreased risk of climbing death, and whether mountaineers participating in commercial expeditions differ in their risk of death relative to those participating in traditional climbs
Feature Improvement and Cost Reduction of Baitcasting Fishing Reels for Emerging Markets
Baitcasting fishing reels are a challenging product to sell to new users in emerging markets. Their complex and less-than-intuitive design make them poor candidates for a novice fisherman selecting his or her first fishing reel. Based upon manufacturer constraints and design requirements, our team lowered the price point and improved the usability of the Okuma Cerros baitcasting fishing reel to make it more appealing to a wider range of consumers, especially in emerging markets. This project resulted in a three-phase redesign: reducing cost via alternative materials and replacing bearings with bushings; prototyping a simplified cast control system; and proposing an improved user interface
A Note on E11 and Three-dimensional Gauged Supergravity
We determine the gauge symmetries of all p-forms in maximal three-dimensional
gauged supergravity by requiring invariance of the Lagrangian. It is shown that
in a particular ungauged limit these symmetries are in precise correspondence
to those predicted by the very-extended Kac-Moody algebra E11. We demonstrate
that whereas in the ungauged limit the bosonic gauge algebra closes off-shell,
the closure is only on-shell in the full gauged theory. This underlines the
importance of dynamics for understanding the Kac-Moody origin of the symmetries
of gauged supergravity.Comment: Published versio
DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma
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Tobacco Rattle Virus in Oregon potatoes
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Direct observation of incommensurate magnetism in Hubbard chains
The interplay between magnetism and doping is at the origin of exotic
strongly correlated electronic phases and can lead to novel forms of magnetic
ordering. One example is the emergence of incommensurate spin-density waves
with a wave vector that does not match the reciprocal lattice. In one dimension
this effect is a hallmark of Luttinger liquid theory, which also describes the
low energy physics of the Hubbard model. Here we use a quantum simulator based
on ultracold fermions in an optical lattice to directly observe such
incommensurate spin correlations in doped and spin-imbalanced Hubbard chains
using fully spin and density resolved quantum gas microscopy. Doping is found
to induce a linear change of the spin-density wave vector in excellent
agreement with Luttinger theory predictions. For non-zero polarization we
observe a decrease of the wave vector with magnetization as expected from the
Heisenberg model in a magnetic field. We trace the microscopic origin of these
incommensurate correlations to holes, doublons and excess spins which act as
delocalized domain walls for the antiferromagnetic order. Finally, when
inducing interchain coupling we observe fundamentally different spin
correlations around doublons indicating the formation of a magnetic polaron
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