Towards unravelling the structural distribution of ultra-high-energy cosmic ray sources

We investigate the possibility that near future observations of ultra-high-energy cosmic rays (UHECRs) can unveil their local source distribution, which reflects the observed local structures if their origins are astrophysical objects. In order to discuss this possibility, we calculate the arrival distribution of UHE protons taking into account their propagation process in intergalactic space i.e. energy losses and deflections by extragalactic magnetic field (EGMF). For a realistic simulation, we construct and adopt a model of a structured EGMF and UHECR source distribution, which reproduce the local structures actually observed around the Milky Way. The arrival distribution is compared statistically to their source distribution using correlation coefficient. We specially find that UHECRs above $10^{19.8}$eV are best indicators to decipher their source distribution within 100 Mpc, and detection of about 500 events on all the sky allows us to unveil the local structure of UHE universe for plausible EGMF strength and the source number density. This number of events can be detected by five years observation by Pierre Auger Observatory.Comment: 7pages, 4 figures, submitted to Ap

Reply to 'Comment on 'Heavy element production in inhomogeneous big bang nucleosynthesis''

This is a reply report to astro-ph/0604264. We studied heavy element production in high baryon density region in early universe astro-ph/0507439. However it is claimed in astro-ph/0604264 that small scale but high baryon density region contradicts observations for the light element abundance or in order not to contradict to observations high density region must be so small that it cannot affect the present heavy element abundance. In this paper we study big bang nucleosynthesis in high baryon density region and show that in certain parameter spaces it is possible to produce enough amount of heavy element without contradiction to CMB and light element observations.Comment: 7 pages, 4 figures, References added, one more reference adde

Local variance of atmospheric 14C concentrations around Fukushima Dai-ichi Nuclear Power Plant from 2010 to 2012

Radiocarbon (14C) has been measured in single tree ring samples collected from the southwest of the Fukushima Dai-ichi Nuclear Power Plant. Our data indicate south-westwards dispersion of radiocarbon and the highest 14C activity observed so far in the local environment during the 2011 accident. The abnormally high 14C activity in the late wood of 2011 ring may imply an unknown source of radiocarbon nearby after the accident. The influence of 14C shrank from 30 km during normal reactor operation to 14 km for the accident in the northwest of FDNPP, but remains unclear in the southwest

A New Method for Calculating Arrival Distribution of Ultra-High Energy Cosmic Rays above 10^19 eV with Modifications by the Galactic Magnetic Field

We present a new method for calculating arrival distribution of UHECRs including modifications by the galactic magnetic field. We perform numerical simulations of UHE anti-protons, which are injected isotropically at the earth, in the Galaxy and record the directions of velocities at the earth and outside the Galaxy for all of the trajectories. We then select some of them so that the resultant mapping of the velocity directions outside the Galaxy of the selected trajectories corresponds to a given source location scenario, applying Liouville's theorem. We also consider energy loss processes of UHE protons in the intergalactic space. Applying this method to our source location scenario which is adopted in our recent study and can explain the AGASA observation above 4 \times 10^{19} eV, we calculate the arrival distribution of UHECRs including lower energy (E>10^19 eV) ones. We find that our source model can reproduce the large-scale isotropy and the small-scale anisotropy on UHECR arrival distribution above 10^19 eV observed by the AGASA. We also demonstrate the UHECR arrival distribution above 10^19 eV with the event number expected by future experiments in the next few years. The interesting feature of the resultant arrival distribution is the arrangement of the clustered events in the order of their energies, reflecting the directions of the galactic magnetic field. This is also pointed out by Alvarez-Muniz et al.(2002). This feature will allow us to obtain some kind of information about the composition of UHECRs and the magnetic field with increasing amount of data.Comment: 10 pages, 8 figures, to appear in the Astrophysical Journa

Ретроспективный анализ врождённых пороков развития у плодов и новорожденных в Гродненском областном перинатальном центре за период 2003-2007 год

НОВОРОЖДЕННЫЙ, БОЛЕЗНИПЛОДА ДИСТРЕС

Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/136512/1/mmi13606.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136512/2/mmi13606_am.pd

A new liver perfusion and preservation system for transplantation Research in large animals

A kidney perfusion machine, model MOX-100 (Waters Instruments, Ltd, Rochester, MN) was modified to allow continuous perfusion of the portal vein and pulsatile perfusion of the hepatic artery of the liver. Additional apparatus consists of a cooling system, a membrane oxygenator, a filter for foreign bodies, and bubble traps. This system not only allows hypothermic perfusion preservation of the liver graft, but furthermore enables investigation of ex vivo simulation of various circulatory circumstances in which physiological perfusion of the liver is studied. We have used this system to evaluate the viability of liver allografts preserved by cold storage. The liver was placed on the perfusion system and perfused with blood with a hematocrit of approximately 20% and maintained at 37°C for 3 h. The flows of the hepatic artery and portal vein were adjusted to 0.33 mL and 0.67 mL/g of liver tissue, respectively. Parameters of viability consisted of hourly bile output, oxygen consumption, liver enzymes, electrolytes, vascular resistance, and liver histology. This method of liver assessment in large animals will allow the objective evaluation of organ viability for transplantation and thereby improve the outcome of organ transplantation. Furthermore, this pump enables investigation into the pathophysiology of liver ischemia and preservation. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted

Quadrupole formula for Kaluza-Klein modes in the braneworld

The quadrupole formula in four-dimensional Einstein gravity is a useful tool to describe gravitational wave radiation. We derive the quadrupole formula for the Kaluza-Klein (KK) modes in the Randall-Sundrum braneworld model. The quadrupole formula provides transparent representation of the exterior weak gravitational field induced by localized sources. We find that a general isolated dynamical source gives rise to the 1/r^2 correction to the leading 1/r gravitational field. We apply the formula to an evaluation of the effective energy carried by the KK modes from the viewpoint of an observer on the brane. Contrary to the ordinary gravitational waves (zero mode), the flux of the induced KK modes by the non-spherical part of the quadrupole moment vanishes at infinity and only the spherical part contributes to the flux. Since the effect of the KK modes appears in the linear order of the metric perturbations, the effective energy flux observed on the brane is not always positive, but can become negative depending on the motion of the localized sources.Comment: 9 pages, no figures, REVTeX 4; version accepted for publication in CQ

Explosive Nucleosynthesis in Axisymmetrically Deformed Type II Supernovae

Explosive nucleosynthesis under the axisymmetric explosion in Type II supernova has been performed by means of two dimensional hydrodynamical calculations. We have compared the results with the observations of SN 1987A. Our chief findings are as follows: (1) $^{44}Ti$ is synthesized so much as to explain the tail of the bolometric light curve of SN 1987A. We think this is because the alpha-rich freezeout takes place more actively under the axisymmetric explosion. (2) $^{57}Ni$ and $^{58}Ni$ tend to be overproduced compared with the observations. However, this tendency relies strongly on the progenitor's model. We have also compared the abundance of each element in the mass number range $A= 16-73$ with the solar values. We have found three outstanding features. (1) For the nuclei in the range $A=16-40$, their abundances are insensitive to the initial form of the shock wave. This insensitivity is favored since the spherical calculations thus far can explain the solar system abundances in this mass range. (2) There is an enhancement around A=45 in the axisymmetric explosion compared with the spherical explosion fairly well. In particular, $^{44}Ca$, which is underproduced in the present spherical calculations, is enhanced significantly. (3) In addition, there is an enhancement around A=65. This tendency does not rely on the form of the mass cut but of the initial shock wave. This enhancement may be the problem of the overproduction in this mass range, although this effect would be relatively small since Type I supernovae are chiefly responsible for this mass number range.Comment: 32 pages, 12 figures, LaTe

Expression of TLR4/MyD88 in CRC

BACKGROUND: The Toll-like receptor (TLR) 4 signalling pathway has been shown to have oncogenic effects in vitro and in vivo. To demonstrate the role of TLR4 signalling in colon tumourigenesis, we examined the expression of TLR4 and myeloid differentiation factor 88 (MyD88) in colorectal cancer (CRC). METHODS: The expression of TLR4 and MyD88 in 108 CRC samples, 15 adenomas, and 15 normal mucosae was evaluated by immunohistochemistry, and the correlations between their immunoscores and clinicopathological variables, including disease-free survival (DFS) and overall survival (OS), were analysed. RESULTS: Compared with normal mucosae and adenomas, 20% cancers displayed high expression of TLR4, and 23% cancers showed high expression of MyD88. The high expression of TLR4 and MyD88 was significantly correlated with liver metastasis (P=0.0001, P=0.0054). In univariate analysis, the high expression of TLR4 was significantly associated with shorter OS (hazard ratio (HR): 2.17; 95% confidence interval (95% CI): 1.15–4.07; P=0.015). The high expression of MyD88 expression was significantly associated with poor DFS and OS (HR: 2.33; 95% CI: 1.31–4.13; P=0.0038 and HR: 3.03; 95% CI: 1.67–5.48; P=0.0002). The high combined expression of TLR4 and MyD88 was also significantly associated with poor DFS and OS (HR: 2.25; 95% CI: 1.27–3.99; P=0.0053 and HR: 2.97; 95% CI: 1.64–5.38; P=0.0003). Multivariate analysis showed that high expressions of TLR4 (OS: adjusted HR: 1.88; 95% CI: 0.99–3.55; P=0.0298) and MyD88 (DFS: adjusted HR: 1.93; 95% CI: 1.01–3.67; P=0.0441; OS: adjusted HR: 2.25; 95% CI: 1.17–4.33; P=0.0112) were independent prognostic factors of OS. Furthermore, high co-expression of TLR4/MyD88 was strongly associated with both poor DFS and OS. CONCLUSION: Our findings suggest that high expression of TLR4 and MyD88 is associated with liver metastasis and is an independent predictor of poor prognosis in patients with CRC