5,109 research outputs found
The Vacuum in Light-Cone Field Theory
This is an overview of the problem of the vacuum in light-cone field theory,
stressing its close connection to other puzzles regarding light-cone
quantization. I explain the sense in which the light-cone vacuum is
``trivial,'' and describe a way of setting up a quantum field theory on null
planes so that it is equivalent to the usual equal-time formulation. This
construction is quite helpful in resolving the puzzling aspects of the
light-cone formalism. It furthermore allows the extraction of effective
Hamiltonians that incorporate vacuum physics, but that act in a Hilbert space
in which the vacuum state is simple. The discussion is fairly informal, and
focuses mainly on the conceptual issues. [Talk presented at {\sc Orbis
Scientiae 1996}, Miami Beach, FL, January 25--28, 1996. To appear in the
proceedings.]Comment: 20 pages, RevTeX, 4 Postscript figures. Minor typos correcte
Control of atomic currents using a quantum stirring device
We propose a BEC stirring device which can be regarded as the incorporation
of a quantum pump into a closed circuit: it produces a DC circulating current
in response to a cyclic adiabatic change of two control parameters of an
optical trap. We demonstrate the feasibility of this concept and point out that
such device can be utilized in order to probe the interatomic interactions.Comment: 5 pages, 4 figures, uses epl2.cls, revised versio
Supersymmetry, Axions and Cosmology
Various authors have noted that in particular models, the upper bound on the
axion decay constant may not hold. We point out that within supersymmetry, this
is a generic issue. For large decay constants, the cosmological problems
associated with the axion's scalar partner are far more severe than those of
the axion. We survey a variety of models, both for the axion multiplet and for
cosmology, and find that in many cases where the cosmological problems of the
saxion are solved, the usual upper bound on the axion is significantly relaxed.
We discuss, more generally, the cosmological issues raised by the pseudoscalar
members of moduli multiplets, and find that they are potentially quite severe.Comment: 27 pages, published version, some discussions clarifie
Sulforaphane rewires central metabolism to support antioxidant response and achieve glucose homeostasis
Cruciferous-rich diets, particularly broccoli, have been associated with reduced risk of developing cancers of various sites, cardiovascular disease and type-2 diabetes. Sulforaphane (SF), a sulfur-containing broccoli-derived metabolite, has been identified as the major bioactive compound mediating these health benefits. Sulforaphane is a potent dietary activator of the transcription factor Nuclear factor erythroid-like 2 (NRF2), the master regulator of antioxidant cell capacity responsible for inducing cytoprotective genes, but its role in glucose homeostasis remains unclear. In this study, we set to test the hypothesis that SF regulates glucose metabolism and ameliorates glucose overload and its resulting oxidative stress by inducing NRF2 in human hepatoma HepG2 cells. HepG2 cells were exposed to varying glucose concentrations: basal (5.5 mM) and high glucose (25 mM), in the presence of physiological concentrations of SF (10 μM). SF upregulated the expression of glutathione (GSH) biosynthetic genes and significantly increased levels of reduced GSH. Labelled glucose and glutamine experiments to measure metabolic fluxes identified that SF increased intracellular utilisation of glycine and glutamate by redirecting the latter away from the TCA cycle and increased the import of cysteine from the media, likely to support glutathione synthesis. Furthermore, SF altered pathways generating NADPH, the necessary cofactor for oxidoreductase reactions, namely pentose phosphate pathway and 1C-metabolism, leading to the redirection of glucose away from glycolysis and towards PPP and of methionine towards methylation substrates. Finally, transcriptomic and targeted metabolomics LC-MS analysis of NRF2-KD HepG2 cells generated using CRISPR-Cas9 genome editing revealed that the above metabolic effects are mediated through NRF2. These results suggest that the antioxidant properties of cruciferous diets are intricately connected to their metabolic benefits
Casimir Energy for a Spherical Cavity in a Dielectric: Applications to Sonoluminescence
In the final few years of his life, Julian Schwinger proposed that the
``dynamical Casimir effect'' might provide the driving force behind the
puzzling phenomenon of sonoluminescence. Motivated by that exciting suggestion,
we have computed the static Casimir energy of a spherical cavity in an
otherwise uniform material. As expected the result is divergent; yet a
plausible finite answer is extracted, in the leading uniform asymptotic
approximation. This result agrees with that found using zeta-function
regularization. Numerically, we find far too small an energy to account for the
large burst of photons seen in sonoluminescence. If the divergent result is
retained, it is of the wrong sign to drive the effect. Dispersion does not
resolve this contradiction. In the static approximation, the Fresnel drag term
is zero; on the mother hand, electrostriction could be comparable to the
Casimir term. It is argued that this adiabatic approximation to the dynamical
Casimir effect should be quite accurate.Comment: 23 pages, no figures, REVTe
Dark Matter, Muon g-2 and Other SUSY Constraints
Recent developments constraining the SUSY parameter space are reviewed within
the framework of SUGRA GUT models. The WMAP data is seen to reduce the error in
the density of cold dark matter by about a factor of four, implying that the
lightest stau is only 5 -10 GeV heavier than the lightest neutralino when m_0,
m_{1/2} < 1 TeV. The CMD-2 re-analysis of their data has reduced the
disagreement between the Standard Model prediction and the Brookhaven
measurement of the muon magnetic moment to 1.9 sigma, while using the tau decay
data plus CVC, the disagreement is 0.7 sigma. (However, the two sets of data
remain inconsistent at the 2.9 sigma level.) The recent Belle and BABAR
measurements of the B -> phi K CP violating parameters and branching ratios are
discussed. They are analyzed theoretically within the BBNS improved
factorization method. The CP parameters are in disagreement with the Standard
Model at the 2.7 sigma level, and the branching ratios are low by a factor of
two or more over most of the parameter space. It is shown that both anomalies
can naturally be accounted for by adding a non-universal cubic soft breaking
term at M_G mixing the second and third generations.Comment: 16 pages, 7 figures, plenary talk at Beyond The Desert '03, Castle
Ringberg, Germany, June 9, 2003. Typos correcte
Investigations in Reduced-Order Aerodynamic Modeling of Aircraft Approaching Stall
No abstract availabl
Differential criterion of a bubble collapse in viscous liquids
The present work is devoted to a model of bubble collapse in a Newtonian
viscous liquid caused by an initial bubble wall motion. The obtained bubble
dynamics described by an analytic solution significantly depends on the liquid
and bubble parameters. The theory gives two types of bubble behavior: collapse
and viscous damping. This results in a general collapse condition proposed as
the sufficient differential criterion. The suggested criterion is discussed and
successfully applied to the analysis of the void and gas bubble collapses.Comment: 5 pages, 3 figure
Observability of the Bulk Casimir Effect: Can the Dynamical Casimir Effect be Relevant to Sonoluminescence?
The experimental observation of intense light emission by acoustically
driven, periodically collapsing bubbles of air in water (sonoluminescence) has
yet to receive an adequate explanation. One of the most intriguing ideas is
that the conversion of acoustic energy into photons occurs quantum
mechanically, through a dynamical version of the Casimir effect. We have argued
elsewhere that in the adiabatic approximation, which should be reliable here,
Casimir or zero-point energies cannot possibly be large enough to be relevant.
(About 10 MeV of energy is released per collapse.) However, there are
sufficient subtleties involved that others have come to opposite conclusions.
In particular, it has been suggested that bulk energy, that is, simply the
naive sum of , which is proportional to the volume, could
be relevant. We show that this cannot be the case, based on general principles
as well as specific calculations. In the process we further illuminate some of
the divergence difficulties that plague Casimir calculations, with an example
relevant to the bag model of hadrons.Comment: 13 pages, REVTe
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