Coseismic horizontal slip revealed by sheared clastic dikes in the Dead Sea Basin

Peer reviewedPostprin

Cancer metabolism at a glance

A defining hallmark of cancer is uncontrolled cell proliferation. This is initiated once cells have accumulated alterations in signaling pathways that control metabolism and proliferation, wherein the metabolic alterations provide the energetic and anabolic demands of enhanced cell proliferation. How these metabolic requirements are satisfied depends, in part, on the tumor microenvironment, which determines the availability of nutrients and oxygen. In this Cell Science at a Glance paper and the accompanying poster, we summarize our current understanding of cancer metabolism, emphasizing pathways of nutrient utilization and metabolism that either appear or have been proven essential for cancer cells. We also review how this knowledge has contributed to the development of anticancer therapies that target cancer metabolism

Adherence to Nutrition and Physical Activity Cancer Prevention Guidelines and Development of Colorectal Adenoma.

Adherence to the American Cancer Society's (ACS) Nutrition and Physical Activity Cancer Prevention Guidelines is associated with reductions in overall cancer incidence and mortality, including site-specific cancers such as colorectal cancer. We examined the relationship between baseline adherence to the ACS guidelines and (1) baseline adenoma characteristics and (2) odds of recurrent colorectal adenomas over 3 years of follow-up. Cross-sectional and prospective analyses with a pooled sample of participants from the Wheat Bran Fiber (n = 503) and Ursodeoxycholic Acid (n = 854) trials were performed. A cumulative adherence score was constructed using baseline self-reported data regarding body size, diet, physical activity and alcohol consumption. Multivariable logistic regression demonstrated significantly reduced odds of having three or more adenomas at baseline for moderately adherent (odds ratio [OR] = 0.67, 95% confidence intervals [CI]: 0.46⁻0.99) and highly adherent (OR = 0.50, 95% CI: 0.31⁻0.81) participants compared to low adherers (p-trend = 0.005). Conversely, guideline adherence was not associated with development of recurrent colorectal adenoma (moderate adherence OR = 1.16, 95% CI: 0.85⁻1.59, high adherence OR = 1.23, 95% CI: 0.85⁻1.79)

Analysis and Resynthesis of the Handpan Sound

(Abstract to follow

A genomic map of the effects of linked selection in Drosophila

Natural selection at one site shapes patterns of genetic variation at linked sites. Quantifying the effects of 'linked selection' on levels of genetic diversity is key to making reliable inference about demography, building a null model in scans for targets of adaptation, and learning about the dynamics of natural selection. Here, we introduce the first method that jointly infers parameters of distinct modes of linked selection, notably background selection and selective sweeps, from genome-wide diversity data, functional annotations and genetic maps. The central idea is to calculate the probability that a neutral site is polymorphic given local annotations, substitution patterns, and recombination rates. Information is then combined across sites and samples using composite likelihood in order to estimate genome-wide parameters of distinct modes of selection. In addition to parameter estimation, this approach yields a map of the expected neutral diversity levels along the genome. To illustrate the utility of our approach, we apply it to genome-wide resequencing data from 125 lines in Drosophila melanogaster and reliably predict diversity levels at the 1Mb scale. Our results corroborate estimates of a high fraction of beneficial substitutions in proteins and untranslated regions (UTR). They allow us to distinguish between the contribution of sweeps and other modes of selection around amino acid substitutions and to uncover evidence for pervasive sweeps in untranslated regions (UTRs). Our inference further suggests a substantial effect of linked selection from non-classic sweeps. More generally, we demonstrate that linked selection has had a larger effect in reducing diversity levels and increasing their variance in D. melanogaster than previously appreciated

BCC vs. HCP - The Effect of Crystal Symmetry on the High Temperature Mobility of Solid 4^4He

We report results of torsional oscillator (TO) experiments on solid $^4$He at temperatures above 1K. We have previously found that single crystals, once disordered, show some mobility (decoupled mass) even at these rather high temperatures. The decoupled mass fraction with single crystals is typically 20- 30%. In the present work we performed similar measurements on polycrystalline solid samples. The decoupled mass with polycrystals is much smaller, $\sim$ 1%, similar to what is observed by other groups. In particular, we compared the properties of samples grown with the TO's rotation axis at different orientations with respect to gravity. We found that the decoupled mass fraction of bcc samples is independent of the angle between the rotation axis and gravity. In contrast, hcp samples showed a significant difference in the fraction of decoupled mass as the angle between the rotation axis and gravity was varied between zero and 85 degrees. Dislocation dynamics in the solid offers one possible explanation of this anisotropy.Comment: 10 pages, 5 figures, to appear in Journal of Low Temperature Physics - special issue on Supersolidit

A Possible Hidden Population of Spherical Planetary Nebulae

We argue that relative to non-spherical planetary nebulae (PNs), spherical PNs are about an order of magnitude less likely to be detected, at distances of several kiloparsecs. Noting the structure similarity of halos around non-spherical PNs to that of observed spherical PNs, we assume that most unobserved spherical PNs are also similar in structure to the spherical halos around non-spherical PNs. The fraction of non-spherical PNs with detected spherical halos around them, taken from a recent study, leads us to the claim of a large (relative to that of non-spherical PNs) hidden population of spherical PNs in the visible band. Building a toy model for the luminosity evolution of PNs, we show that the claimed detection fraction of spherical PNs based on halos around non-spherical PNs, is compatible with observational sensitivities. We use this result to update earlier studies on the different PN shaping routes in the binary model. We estimate that ~30% of all PNs are spherical, namely, their progenitors did not interact with any binary companion. This fraction is to be compared with the ~3% fraction of observed spherical PNs among all observed PNs. From all PNs, ~15% owe their moderate elliptical shape to the interaction of their progenitors with planets, while \~55% of all PNs owe their elliptical or bipolar shapes to the interaction of their progenitors with stellar companions.Comment: AJ, in pres

Phenomenological Constraints on Extended Quark Sectors

We study the flavor physics in two extensions of the quark sector of the Standard Model (SM): a four generation model and a model with a single vector--like down--type quark (VDQ). In our analysis we take into account the experimental constraints from tree--level charged current processes, rare Kaon decay processes, rare B decay processes, the $Z\to b \bar{b}$ decay, $K$, $B$ and $D$ mass differences, and the CP violating parameters \frac \epsilon^\prime}{\epsilon}, $\epsilon_K$ and $a_{\psi K}$. All the constraints are taken at two sigma. We find bounds on parameters which can be used to represent the New Physics contributions in these models ($\lambda_{t^ \prime}^{bd}$, $\lambda_{t^ \prime}^{bs}$ and $\lambda_{t^ \prime}^{sd}$ in the four--generation model, and $U_{bd}$, $U_{bs}$ and $U_{sd}$ in the VDQ model) due to all the above constraints. In both models the predicted ranges for $a_{SL}$ (the CP asymmetry in semi-leptonic decays), $\Delta M_D$, $B(K^+\to\pi^+ \nu \bar{\nu})$, $B(K_L\to\pi^0 \nu \bar{\nu})$ and $B(K_L\to \mu \bar{\mu})_{SD}$ can be significantly higher than the predictions of the SM, while the allowed ranges for $a_{\psi K}$ and for $\Delta m_{B_S}$ are consistent with the SM prediction.Comment: 22 pages, 5 figures (v3: added a reference, updated a reference, added missing units