Discrete cosmological models in the Brans-Dicke theory of gravity

17 pages, 8 figures17 pages, 8 figures17 pages, 8 figure

Psychomotor therapy and aggression regulation in eating disorders

Eating disorder behaviours can be seen as self-destructive behaviours to a greatextent related to inhibited anger expression. However, a treatment protocoltargeted at anger and aggression in these disorders is lacking. This paperdescribes a psychomotor therapy (PMT) model as a body-oriented method tohelp patients with eating disorders to cope with anger and aggression. They learnto see aggression as a positive, relational, body-felt experience, and to controlanger expression at the right time with appropriate intensity. Our clinicalexperience indicates that PMT can accelerate the overall treatment process bytriggering hidden feelings and thoughts and by developing expression skills.This article discusses PMT principles of aggression regulation and themethodological procedures of the intervention. Randomised controlled researchis needed to validate clinical experiences

A quasi-static approach to structure formation in black hole universes

JD and TC both acknowledge support from the STFC under grant STFC ST/N504257/1

Cosmological solutions with charged black holes

RB aknowledges support from the Higher Education Commission (HEC) of Pakistan, which provided funding to visit QMUL while this work was performed. TC and JD are supported by the STFC

Exact initial data for black hole universes with a cosmological constant

We construct exact initial data for closed cosmological models filled with regularly arranged black holes in the presence of $\Lambda$. The intrinsic geometry of the 3-dimensional space described by this data is a sum of simple closed-form expressions, while the extrinsic curvature is just proportional to $\Lambda$. We determine the mass of each of the black holes in this space by performing a limiting procedure around the location of each of the black holes, and then compare the result to an appropriate slice through the Schwarzschild-de Sitter spacetime. The consequences of the inhomogeneity of this model for the large-scale expansion of space are then found by comparing the lengths of curves in the cosmological region to similar curves in a suitably chosen Friedmann-Lemaitre-Robertson-Walker (FLRW) solution. Finally, we locate the positions of the apparent horizons of the black holes, and determine the extremal values of their mass, for every possible regular arrangement of masses. We find that as the number of black holes is increased, the large-scale expansion of space approaches that of an FLRW model filled with dust and $\Lambda$, and that the extremal values of the black hole masses approaches that of the Schwarzschild-de Sitter solution.Comment: 19 pages, 5 figures, v2: matches published versio

Use of quercetin in animal feed : effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken

Modulation of P-glycoprotein (P-gp, encoded by Mdr1) by xenobiotics plays central role in pharmacokinetics of various drugs. Quercetin has a potential to modulate P-gp in rodents, however, its effects on P-gp modulation in chicken are still unclear. Herein, study reports role of quercetin in modulation of P-gp expression and subsequent effects on the pharmacokinetics of enrofloxacin in broilers. Results show that P-gp expression was increased in a dose-dependent manner following exposure to quercetin in Caco-2 cells and tissues of chicken. Absorption rate constant and apparent permeability coefficient of rhodamine 123 were decreased, reflecting efflux function of P-gp in chicken intestine increased by quercetin. Quercetin altered pharmacokinetic of enrofloxacin by decreasing area under curve, peak concentration, and time to reach peak concentration and by increasing clearance rate. Molecular docking shows quercetin can form favorable interactions with binding pocket of chicken xenobiotic receptor (CXR). Results provide convincing evidence that quercetin induced P-gp expression in tissues by possible interaction with CXR, and consequently reducing bioavailability of orally administered enrofloxacin through restricting its intestinal absorption and liver/kidney clearance in broilers. The results can be further extended to guide reasonable use of quercetin to avoid drug-feed interaction occurred with co-administered enrofloxacin or other similar antimicrobials.Peer reviewedFinal Published versio